System for assisting a patient in speaking, comprising at least one ventilation apparatus and a patient interface, the ventilation apparatus comprising at least one controllable respiratory gas source and being designed to identify two or more respiratory phases, at least inspiration and expiration, of the patient, and the patient interface having at least one speaking tube and a respiratory tube and being configured to conduct speaking gas to the patient via the speaking tube and to conduct respiratory gas to and/or from the patient via the respiratory tube. The system is configured to provide speaking gas to the patient at least temporarily in a speaking mode in order to enable speaking.

A ventilation device comprising a controllable respiratory gas source and a programmable control unit being configured to perform the following: determining the respiratory gas flow, which is used to determine whether an inspiration or an expiration is present, regulating the pressure for an inspiration (IPAP) and an expiration (EPAP), wherein the control unit determines a typical expiration time over n breaths, the control unit lowers the pressure from the IPAP to the EPAP taking into account the typical expiration time in such a way that the pressure drop to the EPAP is already reached to the extent of at least 85% after a proportion of the typical expiration time in the range of 40-60% of the typical expiration time, the EPAP after completion of the pressure drop being predefined until the end of the typical expiration time.

A supply arrangement (100) and a process supply a medical device (50, 90) with a supply gas mixture. The supply gas mixture includes a carrier gas and an anesthetic and is generated by an anesthetic dispenser (3). A carrier gas mixing unit (9) generates the carrier gas from at least two carrier gas components. A carrier gas switch having a regular outlet and a discharge outlet selectively directs carrier gas components to the carrier gas mixing unit or to a discharge line (35). A gas mixture switch (6), having a regular outlet (41) and a discharge outlet (42) selectively directs the supply gas mixture to the medical device or to the discharge line (35). An anesthetic concentration sensor (5.1, 5.2) measures a concentration of anesthetic in the generated gas mixture. A control unit (2) controls the gas mixture switch based on measured concentration within or outside a predefined range.

A system may include an external device and an inhaler. The external device may include a processor, a communication circuit, and memory. The inhaler may include a mouthpiece, medicament, a mechanical dose counter, and an electronics module comprising a processor and a communication circuit. The electronics module may record a dosing event when the inhaler is actuated, such as when the mouthpiece cover is opened, and send a signal indicating the dosing event to the external device. The external device may receive a mechanical dose reading of the mechanical dose counter, determine an electronic dose reading based on the signal indicating the dosing event, determine that a discrepancy between the mechanical dose reading and the electronic dose reading exceeds a threshold, and notify the user of the discrepancy, for example, by providing a notification to the user by way of a mobile application residing on the external device.

A patient interface for supplying a flow of breathable gas to the airways of a patient may comprise a heat and moisture exchanger (HME). The HME may be positioned in a flow path of the flow of breathable gas. The HME may absorb heat and moisture from gas exhaled by the patient and the incoming flow of breathable gas to be supplied to the patient's airways may be heated and moisturized by the heat and moisture held in the HME.

The principles and embodiments of the present invention relate to methods and systems for safely providing NO to a recipient for inhalation therapy. There are many potential safety issues that may arise from using a reactor cartridge that converts NO.sub.2 to NO, including exhaustion of consumable reactants of the cartridge reactor. Accordingly, various embodiments of the present invention provide systems and methods of determining the remaining useful life of a NO.sub.2-to-NO reactor cartridge and/or a breakthrough of NO.sub.2, and providing an indication of the remaining useful life and/or breakthrough.

A tank for accumulating oxygen enriched air from an oxygen concentration device is disclosed. The oxygen concentration device includes a canister including a nitrogen-adsorbent material. A compressor is coupled to the canister. The compressor compresses air for the canister to produce oxygen enriched air in a swing adsorption process. The tank includes a closed container for collecting oxygen enriched air produced in the canister. An inlet is coupled to the container. An outlet in the container allows a patient to inhale the collected oxygen enriched air. An adsorbent material within the container adsorbs oxygen enriched air added to the tank from the canister.

The invention relates to a product dispensing device configured to cooperate with a product reservoir that has product dispensing means, having a dispensing duct which is configured to dispense a product from the product dispensing means into the mouth of a user in a manner that is sealed against outside air, trigger means that trigger the dispensing of the product when the air pressure (Ai) in the dispensing duct is a predefined value greater than the pressure of the outside air (A). The invention further relates to a product administration kit having such a product dispensing device and to a product administration unit having such a product dispensing device.

A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, with or without a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, hormones such as insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, diseases and disorders, including endocrine disease such as diabetes and/or obesity.

A mechanical ventilator (10) is connected with a ventilated patient (12) to provide ventilation in accordance with ventilator settings of the mechanical ventilator. Physiological values (variables) are acquired for the ventilated patient using physiological sensors (32). A ventilated patient cardiopulmonary (CP) model (40) is fitted to the acquired physiological variables values to generate a fitted ventilated patient CP model by fine-tuning its parameters (50). Updated ventilator settings are determined by adjusting model ventilator settings of the fitted ventilated patient CP model to minimize a cost function (60). The updated ventilator settings may be displayed on a display component (22) as recommended ventilator settings for the ventilated patient, or the ventilator settings of the mechanical ventilator may be automatically changed to the updated ventilator settings so as to automatically control the mechanical ventilator.