A therapy of oxygen pulses delivered through the pulmonary system of human patient for treating neurodegenerative disorders such as Parkinson Disease (PD), Alzheimer's Disease (AD), Amiotrophic Lateral Sclerosis (ALS) or Motor Neuron Disease (MND) and other dementias, and Lymphedema, Arthritis and Depression is provided. Aspects of the methods including administering to the subjects an effective amount of oxygen as pulses through the respiratory tract are included. Also provided are methods of assessing severity of the disease, mild, moderate, severe, or critical, and oxygen doses and frequencies. The method can be applied to human patient for treating neurodegenerative disorders such as Parkinson Disease (PD), Alzheimer's Disease (AD) Amiotrophic Lateral Sclerosis (ALS) or Motor Neuron Disease (MND) and other dementias, and Lymphedema, arthritis and depression.

Respiratory therapy apparatus includes an oscillating expiratory therapy device and pressure and flow sensors in the patient inlet connected to supply signals to a processor. The processor includes artificial intelligence software to correlate the output signals with prescribed values and control a feedback device that prompts the patient accordingly to adjust use of the device as necessary. The feedback device may be of a visual, audible or tangible kind. The processor may also automatically adjust a setting dial of the therapy device by means of an actuator.

Respiratory assistance device suitable for Auto CPAP respiratory therapy. The respiratory assistance device includes: a blower device including a blower configured to generate pressurized air; an operation device including an operation interface configured to control the blower; a wireless or wired communication arrangement configured to connect the blower device and the operation device; an attachment part configured to be attached to a head of a patient so as to supply the pressurized air to an airway of the patient; and an air tube through which the pressurized air is introduced into the attachment part from the blower device. The blower device is accommodated in a blower device casing, and the operation device is accommodated in an operation device casing separate from the blower device casing.

A gas conduit for respiratory apparatus includes a lumen for passage of a breathable gas to a patient and a flexible conduit wall surrounding the lumen. The flexible conduit wall has a humidification apparatus for delivering water vapour into the gas passing through the lumen.

Provided herein are systems and methods for delivery of therapeutic gas to patients, in need thereof, by receiving breathing gas from a high frequency ventilator using at least enhanced therapeutic gas (e.g., nitric oxide, NO, etc.) flow measurement. At least some of these enhanced therapeutic gas flow measurements can be used to address some surprising phenomenon that may, at times, occur when wild stream blending therapeutic gas into breathing gas a patient receives from a breathing circuit affiliated with a high frequency ventilator. Utilizing at least some of these enhanced therapeutic gas flow measurements the dose of therapeutic gas wild stream blended into breathing gas that the patient receives can at least be more accurate and/or under delivery of therapeutic gas into the breathing gas can be avoided and/or reduced.

A calibration method for an oxygen sensor and a medical ventilation system are disclosed. At least two electrical signals are acquired at two time points within a preset time period, when the oxygen sensor is in a preset oxygen concentration. A response function of the oxygen sensor which corresponds to the preset oxygen concentration, is determined according to the at least two time points and the at least two electrical signals. A steady-state output value of the oxygen sensor in the preset oxygen concentration is determined, according to the response function and a characteristic curve of the oxygen sensor is determined, according to the steady-state output value of the oxygen sensor in the preset oxygen concentration. The described method reduces the time waiting for the oxygen sensor to respond, thus improving calibration efficiency, and facilitating the improvement of the oxygen concentration monitoring accuracy of a ventilation device in daily use.

A cuff pressure management device (10) for a tracheal breathing tube (54) with an inflatable cuff (90), comprises a volume displacement subsystem (36), a pressure transducer (44), a compliance determination circuit (34), and a cuff pressure controller (24). The volume displacement subsystem provides (i) a measured volume of pressurized gas to and from the cuff and (ii) a cuff gas volume signal. The pressure transducer provides a cuff gas pressure signal. The compliance determination circuit is configured to calculate cuff compliance and an estimated tracheal airway compliance based on the gas volume signal and the gas pressure signal. The cuff pressure controller is in controlling communication with the volume displacement subsystem and the compliance determination circuit to maintain cuff pressure based on the calculated cuff compliance.

A portable medical ventilator using pulse flow from an oxygen concentrator to gain higher oxygen concentration includes a positive pressure source to deliver pressurized air to the patient and a negative pressure source to trigger the oxygen concentrator. A patient circuit attached to a patient interface mask connects the ventilator to the patient. The ventilator includes a controller module that is configured to generate a signal to the negative pressure device to trigger the concentrator to initiate one or more pulses of oxygen from the oxygen concentrator. The oxygen pulses are delivered to the patient interface directly through multi-tube or a multi lumen patient circuit. The oxygen does not mix with air in the ventilator or in the patient circuit and bypasses the leaks in the patient circuit and/or patient interface.

A ventilation system that includes a pressure source, a pneumatic path configured to receive gas from the pressure source and comprising a first pneumatic component coupled to a second pneumatic component. The first pneumatic component includes a first electrical conductor including a first electrical component having a first electrical characteristic. The second pneumatic component comprises a second electrical conductor including a second electrical component having a second electrical characteristic. The first electrical conductor is electrically connected with the second electrical conductor in an electric path. The system performs operations including determining a continuity of the electrical path; displaying a notification regarding the continuity of the electrical path; detecting the unique electrical characteristic of the electric path; and determining a pneumatic characteristic of the pneumatic path.

A respiratory assistance apparatus is configured to provide a heated and humidified glow of gases and has a control system that is configured to detect a fault in the flow path. A flow path is provided for a gases stream through the apparatus from a gas inlet through a blower unit and humidification unit to a gases outlet. A flow rate sensor is provided in the flow path and is configured to sense the flow rate and generate an flow rate signal and/or a motor speed sensor is provided that is configured to sense the motor speed of the blower unit and generate an indicative motor speed signal.