A method and system of responding to adverse environmental conditions local to a user of an oxygen concentrator is disclosed. Physiological data of the user is collected. Operational data of the oxygen concentrator is collected during operation of the oxygen concentrator. Environment data local to the oxygen concentrator is collected. Based on the collected environmental data, it is determined whether adverse environmental conditions exist local to the oxygen concentrator. The collected physiological, operational, and environmental data are analyzed to determine a responsive action to the determined adverse environmental conditions. The responsive action is communicated to the user.

Systems and methods for lung-protective ventilation are disclosed. In examples, volume-targeted, pressure-controlled ventilation may deliver mandatory breaths to a patient without a rise time setting. Inputs into the ventilation may include a peak inspiratory flow value (Q.sub.peak) and a target tidal volume (V.sub.T,set). Respiratory parameters of the patient may be determined based on test breaths. The inputs and the respiratory parameters may be used to calculate a target inspiratory pressure (P.sub.i) and target rise time constant (τ). Breaths may then be delivered based on the calculated target inspiratory pressure and target rise time constant. Mechanical power delivered to the patient may also be monitored as an additional measure for patient lung protection.

Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.

The principles and embodiments of the present invention relate to methods and systems for safely providing NO to a recipient for inhalation therapy. There are many potential safety issues that may arise from using a reactor cartridge that converts NO.sub.2 to NO, including exhaustion of consumable reactants of the cartridge reactor. Accordingly, various embodiments of the present invention provide systems and methods of determining the remaining useful life of a NO2-to-NO reactor cartridge and/or a break-through of NO.sub.2, and providing an indication of the remaining useful life and/or break-through.

A device and a system that delivers continuous positive airway pressure in conjunction with oxygen delivery is disclosed. The system is portable so that patients may be mobile and conveniently travel. Several means are disclosed for integrating oxygen production into a positive airway pressure (PAP) device, including oxygen production machinery entirely integrated into the PAP housing, oxygen production machinery that mates with a PAP device but which may operate independently, and where portions of the oxygen production machinery are located in the PAP housing and other portions (for example, the compressor) are located in a separate module, such as, for example, an AC-to-DC power conversion module.

A system, method and software product for detecting and controlling respiratory status of a patient based on estimated respiratory status that includes ventilating a patient using a first electrode, configured to be coupled to a chest of the patient at a first position, and to produce a first electrocardiogram (ECG) signal; a second electrode, configured to be coupled to the chest at a second position different from the first position, and to produce a second ECG signal; and a processor, which is configured to: (i) produce a first filtered signal by applying a first filter to the first ECG signal, and a second filtered signal by applying a second filter to the second ECG signal, (ii) estimate, by comparing between the first and second filtered signals, an electrical impedance between the first and second electrodes, which is indicative of a respiratory status of the patient, and (iii) control the ventilation system to apply a ventilation scheme responsively to the estimated electrical impedance.

A pathogen detection system includes a pathogen sensing adaptor that detect pathogens present in the breathing circuit associated with a ventilated patient. A pathogen sensing adaptor may include a conduit, removable cartridges with testing strips, an optical sensor, and communication circuitry. Upon detecting a colorimetric change on the testing strip, the optical sensor generates a signal indicative of the presence and/or level of pathogens.

An apparatus such as a fluid mixer, suitable for use with a respirator, including a venturi nozzle for flow of a pressure-controlled fluid; an ambient fluid aperture in fluid communication with the venturi nozzle; a fluid port; a pressure force multiplier in fluid communication with the fluid port; and a valve moveable relative to the venturi nozzle between a start flow position and a stop flow position; where the pressure force multiplier is configured such that fluid forced into the fluid port actuates the valve relative to the venturi nozzle; and where the pressure force multiplier is configured such that fluid withdrawn from the fluid port actuates the valve relative to the venturi nozzle. An attachment device, connector, and method of using an apparatus suitable for a ventilator is also disclosed.

An example aerosol delivery device includes a mouthpiece having an airflow outlet, and an airflow passage extending between an airflow inlet and the airflow outlet. The example aerosol delivery device further includes a housing configured to receive a cartridge that includes an aerosolizable substance and a vapor element configured to heat the aerosolizable substance, and an internal power source configured to provide electrical power. The example aerosol delivery device further includes a controller coupled to the internal power source to receive a portion of the electrical power and configured to, when the cartridge is installed at the housing, cause the vapor element of the cartridge to heat the aerosolizable substance to release an aerosol into the airflow passage during an inhalation through the airflow outlet, and a connector configured to receive power from an external source to recharge the internal power source.

A multifunctional ventilator interface for selectively providing ventilation and continuous oxygen therapy to a patient includes tubing defining a high-pressure gas lumen, a low-pressure gas lumen, and a pressure sensing lumen, a manifold housing defining a gas pathway, a jet pump housing coupled to the manifold housing and defining an entrainment port, a sleeve rotatably engaged to the jet pump housing, and a jet nozzle defining high- and low-pressure jet nozzle outlet ports operative to introduce gas from the high- and low-pressure gas lumens into the gas pathway. The sleeve includes first and second windows selectively alignable with the entrainment port by rotation of the sleeve, the first window configured to allow ambient air to flow into the entrainment port when at least partially aligned therewith, the second window being covered by a one-way valve configured to prevent ambient air from flowing into the entrainment port but to allow exhalation out of the entrainment port when the second window is at least partially aligned therewith.