Systems and methods for nitric oxide (NO) generation systems are provided. In some embodiments, an NO generation system comprises at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas. The electrodes have elongated surfaces such that a plasma produced is carried by the flow of the reactant gas and glides along the elongated surfaces from a first end towards a second end of the electrode pair. A controller is configured to regulate the amount of NO in the product gas by the at least one pair of electrodes using one or more parameters as an input to the controller. The one or more parameters include information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which the product gas flows.

A carbon dioxide absorber (1) and a closed-circuit breathing apparatus (2) with the carbon dioxide absorber are based on the carbon dioxide absorber having an inlet (3) and an outlet (4) gas-tight connectable by a flow duct (5), in which a material (6) is arranged, which absorbs some carbon dioxide contained in the breathing gas stream sent through the material. The flow duct (5) is enclosed in some areas by a housing (7), in which a window element (8) is arranged. A display element (9) arranged movably in the flow duct (5) is visible through the window element from outside of the housing and/or through which window element the radiation reflected by the display element (9) exits to the outside. A distance between the window element (8) and the display element (9) varies as a function of the quantity of carbon dioxide-absorbing material arranged in the flow duct (5).

A device and method for adjusting a tidal breath delivered to a patient. The device includes a moving frame which is configured to move over a stationary frame that is nested within the moving frame itself. Disposed between the moving frame and the stationary frame is a compressible bellows which delivers a tidal breath to the patient each time the moving frame is passed over the stationary frame. The specific volume of the tidal breath that is delivered may adjusted according to the estimated weight of the patient, thereby preventing over inflation of the patient's lungs while undergoing treatment. To adjust the tidal breath volume, the user quickly changes the relative position of a slide selector which dictates the range of possible movement for the bellows to be compressed, thereby limiting the volume of air/oxygen which may be delivered by the bellows.

The Shared Manifold Ventilator uses low pressure breathing gas manifolds to interface directly with patients in a hospital ward, through solenoid valves in such a way that it achieves lower cost per patient ventilated than prior art methods while still allowing full control of the breathing cycle and oxygen concentration for each individual patient.

A reusable apparatus, such as a medical instrument or tool, is decontaminated by applying at least one of pressure waves, shockwaves, and ultrasound waves in a sufficient dosage to remove contamination but without adversely affecting the ability to reuse the apparatus.

A process for monitoring a measuring system (110) for mechanical ventilation of a patient (20) is carried out while a fluid connection (40) is established between the patient (20) and a medical device (100). A gas sample is suctioned from the fluid connection (40) and is sent through a gas sensor fluid-guiding unit (52) to a gas sensor array (50). A time curve of the CO2 concentration and O2 concentration in the suctioned gas sample are determined. A concentration change curve of the change over time of the CO2 concentration and the O2 concentration are calculated. A search is made for a time period in which the two concentration change curves continuously have the same sign. Upon detecting such a time period it is checked whether a predefined first leak criterion is met. When this is the case, an indication of a leak (L) is detected.

Provided herein are methods of treatment, including methods of treating subjects having or at risk of having or having a viral infection, and specifically a SARS-CoV-2 viral infection. The methods provided include the administration of 4-methylumbelliferone (4-MU), palmitoylethanolamide (PEA), reservatrol, fisetin, H.sub.2, nebulized hyaluronidase or combinations thereof. Also provided herein are a respiratory assistance device, methods of generating a customized respiratory assistance device, methods of treating a coronavirus infection, and methods of inhibiting a coronavirus infectivity, virulence and/or spread.

A breathing bag (20) has a tray section (21) and a bag section (22). The tray section (21) and the bag section enclose an inner volume (24) of variable size, the bag section dipping at least partially into the tray section to reduce the size of the inner volume. A system (10) includes the breathing bag, for a closed-circuit respirator (100), with a dispensing valve unit (40) having a dispensing valve (41) providing a quantity of gas in a breathing circuit. An actuating unit (42) is functionally connected mechanically to the dispensing valve for actuating the dispensing valve. A lever component (50) is functionally connected mechanically to the actuating unit for activating the actuating unit. A closed-circuit respirator has the system including the breathing bag and the dispensing valve unit. A process is provided for mounting the system, including breathing bag and dispensing valve unit, in the closed-circuit respirator.

A portable ventilator module is provided and includes a data module capable of artificial intelligence (AI) and/or machine learning (ML). The ventilator module is detachably attachable to an anaesthesia module to enable a single device to collect data from a patient in critical care and theatre environments. Also provided is a system for the unbroken acquisition of data from the entire patient stay in critical care, emergency areas and theatres in a single device by including a data module capable of AI or ML within a portable ventilator module, wherein the portable ventilator module can provide life-sustaining ventilation support to a patient in critical care and wherein the portable ventilator can dock with an anaesthesia module to provide anaesthesia during operations in theatre so that a machine change from an ICU ventilator to a separate anaesthesia machine and back again is not required, thereby avoiding data loss.

Devices and methods for delivering air to a patient are provided. A device includes a first portion having a first airflow inlet and a sensor configured to sense airflow, the first portion defining a first airflow path, and a second portion comprising a second airflow inlet, an impeller, and an outlet for communicating airflow to a patient, the second portion defining a second airflow path. The device includes means for coupling the first portion and the second portion, such that the sensor sensing airflow in the first portion causes corresponding movement of the impeller, wherein the impeller is configured to impel air through the second airflow inlet and out of the outlet to the patient, upon movement of the impeller.