A respiratory ventilation device—for sending a fan-generated air flow into a duct extending to a respiratory mask—extends between lower (bottom) and upper ends. A ventilation chamber contains the fan and is connected to a humidifier, which has a water-accommodating reservoir and a connecting chamber adjacent the ventilation chamber. An intake opening leads out of the ventilation chamber. An exhaust opening leads into an exhaust channel attachable to the duct. A humidification chamber has the water reservoir. First and second openings are formed between the connecting and humidification chambers. The connecting chamber extends between the humidification and ventilation chambers. A separating wall extends between the connecting and humidification chambers. The first and second openings are made in the separating wall, which is arranged such that the humidification chamber extends between the bottom and the separating wall. The connecting chamber extends between the separating wall and the ventilation chamber.

A patient interface may include a dual chamber cushion assembly having a nasal chamber and an oral chamber. The nasal chamber may be arranged to deliver pressurized breathable gas to a patients nasal passages, and the oral chamber may be arranged to deliver pressurized breathable gas to the patients oral passages. The nasal chamber may be pressurized to a different level than an oral chamber to promote nasal breathing. An air passage may fluidly connect the nasal chamber and the oral chamber so that pressurized breathable gas may flow from the nasal chamber to the oral chamber.

Aspects of the present technology comprise a positioning and stabilising structure to hold a seal-forming structure in a therapeutically effective position on a head of a patient. The seal-forming structure may be constructed and arranged to form a seal with a region of the patients face surrounding an entrance to the patients airways for sealed delivery of a flow of air at a therapeutic pressure of at least 4 cmH2O with respect to ambient air pressure throughout the patients respiratory cycle in use. The positioning and stabilising structure may comprise a front hoop arranged to contact, in use, at least a region of the patients head superior to an otobasion superior of the patients head and a rear strap. The positioning and stabilising structure may comprise an adjustment mechanism for adjustment of the front hoop and the rear strap relative to the patients head, the adjustment mechanism being arranged in a single operation to adjust both the front hoop and rear strap to enable the positioning and stabilising structure to fit different size heads.

A patient interface a positioning and stabilising structure, which includes a gas delivery tube with a tube wall that has an interior passage for flow of pressurized air. A portion of the tube wall includes a patient contacting portion and a non-patient contacting portion. The patient contacting portion includes a layer of textile material or foam material configured to lie against the patient's head. At least a section of the non-patient contacting portion includes of a transparent and/or translucent material. The layer of textile material or foam material is bonded to the transparent and/or translucent material so that the tube wall is formed as a one piece construction. A plane extends generally transverse to longitudinal axis contains both (1) the textile material or foam material and (2) the transparent and/or translucent material, so that the patient may view the interior passage along a transverse axis extending through the plane.

Embodiments of the innovation relate to a ventilator, comprising: a positive displacement pump having a drive motor and configured to output a predetermined volume of inspiratory gas for each rotation of an output shaft of the drive motor; at least one pressure sensor configured to measure inspiratory pressure; and a control unit having a controller comprising a memory and a processor, the control unit disposed in electrical communication with the drive motor and with the at least one pressure sensor. The controller is configured to: receive at least one of an operation signal and a pressure sensor signal, and transmit a drive motor control signal to the drive motor to adjust at least one of a rotational speed of the output shaft and a number of rotations of the output shaft based upon the at least one of the operation signal and the pressure sensor signal.

A fluid plug for use with sterile processes such as the manufacture or production of pharmaceuticals and biologics is disclosed. The fluid plug is made of a material or materials that will tolerate sterilizing processes such as gamma irradiation. The fluid plug is used to selectively plug the ends of flexible polymer conduits that may be connected to fluids, reagents, or products used or generated as part of the manufacturing process. Also disclosed is the use of the plugs in combination with a series of valves in a block-and-bleed arrangement to enable the sterile transfer and connection of fluids, reagents, or products within a process flow.

A patient interface kit to deliver a flow of air at a positive pressure with respect to ambient air pressure to an entrance to a patients airways including at least the entrance of a patients nares while the patient is sleeping. The patient interface comprising: a nasal cushion having a nasal cushion opening; a mouth cushion having a mouth cushion opening, the mouth cushion including a flexible joint, positioned above the mouth opening, to selectively connect the nasal cushion to the mouth cushion; and a positioning and stabilizing structure to provide a force to hold the nasal and/or mouth seal-forming structures in a therapeutically effective position on a patient's head, the positioning an stabilizing structure including a nasal headgear including upper straps or conduits and a mouth headgear including lower straps, the mouth headgear being selectively connected to the nasal headgear.

A patient interface including a seal-forming structure with a textile membrane that has at least one hole such that the flow of air at a therapeutic pressure is delivered to at least an entrance to the patients nares and/or an entrance to the patients mouth. The seal-forming structure is constructed and arranged to maintain the therapeutic pressure in a cavity of a plenum chamber throughout the patients respiratory cycle, in use. The textile membrane includes a first portion that is held in a relaxed state and a second portion that is held in a taut state. The taut state of the second portion is configured to allow the seal-forming structure to include a three-dimensional shape that has multiple curvatures.

In some examples, a device comprises a sanitizing member including a hollow tube having a reflective inner surface and first and second ends. The sanitizing member includes an ultraviolet (UV) light-emitting diode (UV-LED) at the first end. The second end has an orifice exposing the reflective inner surface to an environment of the device. The device also includes a facemask having an air valve coupled to the sanitizing member.

A patient interface for delivery of a supply of pressurised air or breathable gas to an entrance of a patient's airways includes a frame member, a cushion assembly provided to the frame member, and an anterior wall member repeatedly engageable with and disengageable from the cushion assembly. The frame member includes connectors operatively attachable to a positioning and stabilizing structure. The cushion assembly includes a seal-forming structure and a void defined by an anterior surface of the cushion assembly. The anterior wall member has a predetermined surface area to seal the void of the cushion assembly and form a gas chamber when the anterior wall member and the cushion assembly are engaged. The void of the cushion assembly is sized such that the patient's nose and/or mouth is substantially exposed when the anterior wall member is disengaged from the cushion assembly thereby improving breathing comfort of the patient.