A respiratory delivery system providing a bi-level pressure airflow. The system includes respiratory and pneumatic circuits. The respiratory circuit includes a respiratory gas supply, a patient interface, and a bi-level pressure regulator. The respiratory gas supply supplies a respiratory gas to the patient interface via a first conduit. The bi-level pressure regulator is coupled to the patient interface via a second conduit and is configured to cyclically alternate the respiratory gas passing through the bi-level pressure regulator between a low-pressure level and a high-pressure level. The pneumatic circuit includes a pneumatic gas supply and a pneumatic cycler configured to output a cycling pressure level. The cycler is coupled to the bi-level pressure regulator via a third conduit. The bi-level pressure regulator cyclically alternates the pressure level of the respiratory gas between the low-pressure level and the high-pressure level with the timing defined by the cycling of the pneumatic gas.

A system and process for an oxygen flow control system for supplemental oxygen is provided, including a system with an optical flow sensor and 3-way solenoid that operate to detect inhalation and deliver a microburst of oxygen that is electronically controlled based on one or more parameters.

A system for providing continuous positive air pressure therapy is provided. The system includes a flow generator, a sensor, and a computing device. The computing device is configured to control operation of the flow generator based on sensor data. The computing device is further configured to display, on a display device, one or more questions relating to demographic and/or subjective feedback; responsive to displaying the one or more questions, receive one or more inputs indicating answers to the one or more questions; transmit the answers to a remote processing system; receive, from the remote processing system, settings determined based on the transmitted answers; and adjust control settings of the system based on the received settings.

A novel oxygen pulse therapy methods of treating subjects suffering from COVID19 and other respiratory and others diseases are provided. Aspects of the methods including administering to the subjects an effective amount of oxygen as pulses through the respiratory tract are included. Also provided are methods of assessing severity of the disease, mild, moderate, severe, or critical, and oxygen doses and frequencies. The method can be applied to viral, bacterial, fungal or parasitic respiratory and others diseases infections such as corona virus (SARS-CoV-2), influenza virus such as influenza A or rotavirus, bacterial pneumonia and meningitis such as Streptococcus pneumonia or parasitic and other diseases such AIDS, Ebola, tuberculosis and malaria.

Systems and techniques for monitoring, predicting and/or alerting for short-term oxygen support needs of patients are presented. A system can include a data collection component that receives multimodal patient data for a patient having a respiratory condition in association with monitoring and treating the respiratory condition in real-time, the multimodal patient data comprising at least physiological data regarding physiological parameters tracked for the patient over a period of time, and current oxygen support data regarding a current oxygen support mechanism of the patient. The system can further include an oxygen support forecasting component that processes the multimodal patient data using an oxygen support forecasting model to generate an output forecast that indicates whether a change to the current oxygen support mechanism is recommended for the patient within a defined upcoming timeframe

Disclosed herein are methods, systems, and devices for controlling a gas mixture within a mechanical ventilator. According to one embodiment, a computer implemented method includes receiving first peripheral arterial oxygen saturation (SpO.sub.2) data from a pulse oximeter via a pulse oximeter interface, wherein the pulse oximeter is configured to monitor a patient receiving invasive ventilation; determining a first mode of operation for a ventilator mechanism, wherein the ventilator mechanism is configured to provide at least a portion of the invasive ventilation; determining first partial pressure of oxygen (PaO.sub.2) data stored in a first lookup table using the first SpO.sub.2 data, wherein the first lookup table is derived from a sigmoid shaped oxyhemoglobin dissociation curve; determining first fraction of inspired oxygen in air (FiO.sub.2) data for setting a mixture in a gas blender in the ventilator mechanism based on the first PaO.sub.2 data and a variable offset; and providing the FiO.sub.2 data to the ventilator mechanism.

A patient valve for ventilating a patient with a ventilator, including a first valve element having at least one connection, wherein the at least one connection is oriented with the central axis thereof at an angle deviating from the vertical position in relation to the patient valve central axis, such that a shortened patient valve having a reduced dead space volume is supported.

Systems and methods for calibrating oxygen sensors in ventilators are provided. An oxygen sensor is coupled in flow communication with a first oxygen gas source. A calibration circuit including a second oxygen gas source is coupled in flow communication with the oxygen sensor and a third oxygen gas source is coupled in flow communication with the oxygen sensor. A controller is configured to determine a calibration curve for the oxygen sensor via the calibration circuit by measuring the second oxygen gas source and the third oxygen gas source. Based on the calibration curve, an oxygen concentration value of the first oxygen gas source is measured and distributed.

Disclosed herein is a system and method for controlling oxygen supply equipments. The system is equipped with pressure sensors coupled to the oxygen supply equipments. Depending on the oxygen supply selected by a user for the patient, the pressure sensor monitors the current pressure of the preset oxygen supply during an inhalation phase corresponding to the patient. If the current pressure is less than a minima value or if a pressure drop rate is higher than or equal to a threshold rate or both, the system generates an alarm notifying the user to check the preset oxygen supply and in the meanwhile switches the preset oxygen supply from one oxygen supply equipment to another oxygen supply equipment or vice-versa.

In a method of ventilating excised lungs, a ventilation gas is supplied to an airway of a lung and a vacuum is formed around the lung. A quality of the vacuum is varied between a lower level and a higher level to cause the lung to breathe, while the pressure of the ventilation gas supplied to the airway is regulated to maintain a positive airway pressure in the airway of the lung. The vacuum may be cyclically varied between the two vacuum levels. The levels may be maintained substantially constant over a period of time, or one or both of the lower and higher levels may be adjusted during ventilation. The lung may be placed in a sealed chamber, and a vacuum is formed in the chamber around the lung.