A method of controlling a flow rate of gases supplied to a patient by a respiratory assistance device includes controlling the supply gases flow rate so as to deliver gases to the patient according to a predetermined gases pressure/flow rate profile for at least a portion of the breathing cycle. A profile may be achieved that provides the patient with a particular benefit or therapy.

An anesthesia ventilator, for the automated ventilation of a patient, includes an expiratory port and an inspiratory port for connecting a ventilation tube facing the patient for a breathing gas, a breathing gas delivery unit, at least one breathing gas sensor for detecting an anesthetic gas concentration, at least one pressure sensor for detecting a pressure of the breathing gas, as well as at least one computer. The computer is configured to actuate the breathing gas delivery unit as a function of the detected pressure of a preset desired pressure value. The computer is further configured to perform an adaptation of the desired pressure value as a function of the detected anesthetic gas concentration.

The present invention generally relates to, amongst other things, systems, devices, materials, and methods that can improve the accuracy and/or precision of nitric oxide therapy by, for example, reducing the dilution of inhaled nitric oxide (NO). As described herein, NO dilution can occur because of various factors. To reduce the dilution of an intended NO dose, various exemplary nasal cannulas, pneumatic configurations, methods of manufacturing, and methods of use, etc. are disclosed.

A process for monitoring a measuring system (110) for mechanical ventilation of a patient (20) is carried out while a fluid connection (40) is established between the patient (20) and a medical device (100). A gas sample is suctioned from the fluid connection (40) and is sent through a gas sensor fluid-guiding unit (52) to a gas sensor array (50). A time curve of the CO2 concentration and O2 concentration in the suctioned gas sample are determined. A concentration change curve of the change over time of the CO2 concentration and the O2 concentration are calculated. A search is made for a time period in which the two concentration change curves continuously have the same sign. Upon detecting such a time period it is checked whether a predefined first leak criterion is met. When this is the case, an indication of a leak (L) is detected.

A portable ventilator module is provided and includes a data module capable of artificial intelligence (AI) and/or machine learning (ML). The ventilator module is detachably attachable to an anaesthesia module to enable a single device to collect data from a patient in critical care and theatre environments. Also provided is a system for the unbroken acquisition of data from the entire patient stay in critical care, emergency areas and theatres in a single device by including a data module capable of AI or ML within a portable ventilator module, wherein the portable ventilator module can provide life-sustaining ventilation support to a patient in critical care and wherein the portable ventilator can dock with an anaesthesia module to provide anaesthesia during operations in theatre so that a machine change from an ICU ventilator to a separate anaesthesia machine and back again is not required, thereby avoiding data loss.

Provided are an anesthesia respiration apparatus, an anesthesia respiration gas path system, and an anesthetic gas path system, to exhibit a novel anesthesia respiration structure. In this structure, some channels are provided in an anesthesia main machine, and no long external pipeline or only a small number of long pipelines are required to meet demands of gas path connection, thereby reducing various potential safety hazards and inconvenience caused by excessive exposed long pipelines.

Various systems and devices for generating nitric oxide are disclosed herein. According to one embodiment, the device includes a body having an inlet, an outlet, and a porous solid matrix positioned with the body. The porous solid matrix is coated with an aqueous solution of an antioxidant, wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the solid matrix to convert nitrogen dioxide in the gas flow into nitric oxide. The porous solid matrix allows the device to be used in any orientation. Additionally, the porous solid matrix provides a rigid structure suitable to withstand vibrations and abuse without compromising device functionality.

A device and method for calibrating a delivery device includes providing a container A containing a nitrite, providing a container B containing an acid, releasing the contents of containers A and B, allowing the nitrite and acid to mix, waiting for a predetermined time, allowing air to combine with the mixture, and using NO and traces of NO.sub.2 to check and calibrate NO and NO.sub.2 sensors.

A medical breathing gas delivery system design employs a manifold delivering gas in a controlled fashion to patients which includes two inhaled gas one-way valves, at least one pressure sensor for patient airway pressure monitoring, and one controlled exhalation pressure proportional control valve which may be overridden by patient exhaled pressure or if there is a power loss. The manifold is connected to a controlled source of breathing gas which may, for example, be a variable-speed fan, or a pressure-based gas flow controller with dynamic self-calibration employing a fast-acting valve and a pressure sensor, either of which yield predictable gas flow control with a minimum of components. The manifold exhalation pressure control valve and gas flow source may, for example, be controlled with a computer system which adjusts the valve power waveforms to attain the time-varying flow and pressure curves required by clinicians, then stores and displays the waveforms to enable long-term trend monitoring and alarm generation. Accurate gas mixing using the pressure-based gas flow control yields automatically calibrated mixes which are of use for patients in, for example, intensive care ventilation and in anesthesia machines for operating rooms.

Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. A nitric oxide delivery system that converts nitrogen dioxide to nitric oxide employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid.