A method of transplanting a sleep state of a first subject (donor) to a second subject (recipient) comprising: capturing a sleep state of the first subject represented by brain activity patterns; and transplanting the sleep state of the first subject in the second subject by inducing the brain activity patterns in the second subject.

The present disclosure pertains to a system and method for automatically detecting rapid eye movement (REM) sleep and delivering sensory stimulation to prolong REM duration, without disturbing sleep. The sensory stimulation may be auditory or other stimulation. The system and method ensure timely delivery of the stimulation and automatically adjust the amount, intensity, and/or timing of stimulation as necessary. REM sleep is detected based on brain activity, cardiac activity and/or other information. REM sleep may be detected and/or predicted by a trained neural network. The amount, timing, and/or intensity of the sensory stimulation may be determined and/or modulated to enhance REM sleep in a subject based on one or more values of one or more intermediate layers of the neural network and one or more brain activity and/or cardiac activity parameters.

A hand stimulation device that includes a housing defining an interior plenum and having a top portion and a bottom portion; a pair of drive electrodes structured and arranged in a first region of the top portion; a pair of sense electrodes structured and arranged in a second region of the top portion; a processing device disposed within the interior plenum and in communication with each of the pair of drive electrodes and the pair of sense electrodes; at least one sensing device adapted to measure and collect biometric data about the user; and at least one motor that is adapted to generate at least one of tactile feedback and a haptic pattern to a user.

Typically, high NREM stage N3 sleep detection accuracy is achieved using a frontal electrode referenced to an electrode at a distant location on the head (e.g., the mastoid, or the earlobe). For comfort and design considerations it is more convenient to have active and reference electrodes closely positioned on the frontal region of the head. This configuration, however, significantly attenuates the signal, which degrades sleep stage detection (e.g., N3) performance. The present disclosure describes a deep neural network (DNN) based solution developed to detect sleep using frontal electrodes only. N3 detection is enhanced through post-processing of the soft DNN outputs. Detection of slow-waves and sleep micro-arousals is accomplished using frequency domain thresholds. Volume modulation uses a high-frequency/low-frequency spectral ratio extracted from the frontal signal.

Transdermal electrical stimulation (TES) applicators that are wearable and configured to attached to a subject's pinna (ear) and adapted to apply TES to modulate the subject's cognitive and/or physiological state. These apparatuses may be configured so that they can be worn against the ear (e.g., the cymba of the ear) to deliver TES. Also described herein are methods of using them to modulate a subject's cognitive state. These TES applicators may also be adapted to function as audio headphones for concurrent delivery of TES and audible signals (e.g., music).

The present application discloses and describes neurostimulation systems and methods that include, among other features, (i) neural stimulation through audio with dynamic modulation characteristics, (ii) audio content serving and creation based on modulation characteristics, (iii) extending audio tracks while avoiding audio discontinuities, and (iv) non-auditory neurostimulation and methods, including non-auditory neurostimulation for anesthesia recovery.

A method for inducing a hibernation-like state and a device for the same is described. The method is a chemical and physical method for reducing, in a subject, a theoretical set-point temperature of a body temperature and/or a feedback gain of heat production, or for inducing a hibernation-like state in the subject, the method including applying an excitatory stimulus to pyroglutamylated RFamide peptide (QRFP)-producing neurons. A device used to implement the method is also described.

A rehabilitation assistant system for patients with cognitive impairments, including an audio stimulation unit, an acupoint stimulation unit, a phototherapeutic unit, an electronic stimulation unit, a display and optical frequency-flashed stimulation unit and a control unit. The audio stimulation unit broadcast a binaural beats with frequency following response, and the acupoint stimulation unit includes several acupoint agents to output physical stimulation to a user. The phototherapeutic unit includes two near-infrared light groups, and the electronic stimulation unit includes two electrical stimulation agents to output physical stimulation to the user. The display and optical frequency-flashed stimulation unit is switchable between a display mode and an optical frequency-flashed stimulation mode, and the control unit simultaneously controls the audio stimulation unit to broadcast the binaural beats with frequency following response so as to improve the rehabilitation efficiency in patients with cognitive impairment.

The subject matter described herein provides systems and techniques for enhancing a user’s performance. In particular, the physiological characteristics of the user can be altered toward target characteristics to bring about a particular physiological state in the user. Multiple physiological signals of the user may be sensed. Physiological characteristics indicative of a physiological state of the user may be determined. A differential between the physiological characteristics and selected target physiological characteristics may be determined. A selected energy signal associated with a correction action may be communicated to nerves associated with the user’s skin by outputting, using an energy generator, the energy signal toward the skin with one or more different energy types based on the differential. This may allow a particular targeted physiological state to be more rapidly brought about in the user.

A blood pressure lowering training device comprises a head frame unit corresponding to a user's head shape, an audio stimulation unit for broadcasting binaural beats with frequency following response to both ears of the user, a display unit including a display module for displaying a virtual image and blood pressure information and a blood pressure measurement module for measuring blood pressure, and a control unit electrically connected with the audio stimulation unit and the display unit, so that the hypertensive patient can perform a variety of adjustable blood pressure lowering training in one use process, and effectively improve the use intention of the hypertensive patient.