Methods are provided for acute treatment of agitation, including agitation in patients with schizophrenia or bipolar disorder, comprising administering to a subject with agitation an effective dose of a dry pharmaceutical composition comprising olanzapine, wherein the dose is administered by an intranasal delivery device that provides, following intranasal administration, (a) a mean peak plasma olanzapine concentration (C.sub.max) of at least 30 ng/mL, with (b) a mean time to C.sub.max (T.sub.max) of olanzapine of less than 0.5 hours. Dry pharmaceutical compositions and devices suitable for intranasal delivery of olanzapine are provided.

Provided is a smart inhaler and wearable smart mask configured to operate as an air ionizer and a controlled multi-liquid atomizer. The smart mask and smart inhaler use a mature technology to deliver various types of liquid solutions to different applications from health care, drug delivery, immunization to recreational and gaming uses. In addition, the smart mask contains multiple actuators to provide haptic feedback to the areas around the mask. The smart mask and inhaler have a direct communication path to a smart device or it can be a smart device by itself; its various environmental and gas sensors act as a feedback mechanism. The detection level of the organic and non-organic VOC gas emitted when exhaling can be communicated and stored for analysis purposes. The detected gas can be regenerated on the same smart mask or a different remote smart mask.

The present invention relates to a sleep-inducing system using carbon dioxide. The sleep-inducing system includes a mixed gas generation unit which generates a mixed gas of which a carbon dioxide concentration is within a preset range by mixing provided carbon dioxide and air, an emission unit which sprays the mixed gas from a position spaced apart from a user's face, a concentration sensing sensor which measures the carbon dioxide concentration of the sprayed mixed gas, and a control unit which controls the carbon dioxide concentration of the mixed gas generated by the mixed gas generation unit to be within the preset range on the basis of the measured carbon dioxide concentration.

The present disclosure provides an aerosol delivery device and a liquid delivery and atomization assembly for use with an aerosol delivery device. In one implementation, the liquid delivery and atomization assembly comprises a liquid composition, an atomization assembly, and a liquid delivery component configured to transport at least a portion of the liquid composition to the atomization assembly. The liquid delivery component comprises at least one microchannel configured to deliver the portion of the liquid composition to the atomization assembly, and the microchannel includes a variable flow characteristic defined along at least a portion of the microchannel, the variable flow characteristic being configured to control the flow of the portion of liquid composition through the microchannel.

An anti-drowsiness device includes a head cover; an electroencephalograph, which is formed on the head cover, the electroencephalograph receiving the brain-waves all the time and generating a sleep-detection signal when a specific frequency, which shows drowsiness, is received, and an electrostimulator, which is formed on the head cover, the electrostimulator generating electrostimulation when receiving the sleep-detection signal.

A method of transplanting a desired emotional state from a donor to a recipient, comprising determining an emotional state of the donor; recording neural correlates of the emotional state of the donor who is in the desired emotional state; analyzing neural correlates of the emotional state of the donor to decode at least one of a temporal and a spatial pattern corresponding to the desirable emotional state; converting said at least one of a temporal and a spatial pattern corresponding to the desirable emotional state into a neurostimulation pattern; storing the neurostimulation pattern in the nonvolatile memory; retrieving the neurostimulation pattern from the nonvolatile memory; stimulating the recipients brain with at least one stimulus modulated with the neurostimulation pattern to induce the desired emotional state in the recipient.

Altering consciousness by transcranial stimulation to adjust the membrane potential duration (FIG. 1, Ref. 7) of sensory cortex dendritic spine necks (FIG. 1, Ref 6); sensory cortex spine neck membranes are conscious.

Combinatorial therapeutic systems can include an artificial sensory experience and a therapeutically effective amount of an analgesic selected from tapentadol or difelikefalin (CR845). Methods for treating and/or mitigating pain can include at least (i) receiving a therapeutic dose of an analgesic selected from tapentadol or difelikefalin (CR845) and (ii) receiving an artificial sensory experience. The artificial sensory experience can include one or more of 2D/3D/4D artificial sensory experiences, holography, augmented reality, virtual reality, and/or mixed reality. In some instances, the artificial sensory experience is virtual reality neuropsychological therapy or virtual reality distraction therapy.

Systems and methods for managing sleep quality of a patient, comprising: collecting physiological signal data of the patient using a data acquisition unit electrically coupled to at least one sensor affixed to the patient that generates the physiologic signal data; using one or more hardware processors executing instructions stored in a storage device: filtering the physiological signal data into a plurality of frequency bands corresponding to a plurality of power spectra waveforms; and characterizing an etiology of sleep quality of the patient based on a comparison of at least a first power spectra waveform of the plurality of power spectra waveforms against at least a second power spectra waveform of the plurality of power spectra waveforms, wherein the sleep quality of the patient is managed based on the characterized etiology of sleep.

Systems, methods and devices for paired training include timing controls so that training and neural stimulation can be provided simultaneously. Paired trainings may include therapies, rehabilitation and performance enhancement training. Stimulations of nerves such as the vagus nerve that affect subcortical regions such as the nucleus basalis, locus coeruleus or amygdala induce plasticity in the brain, enhancing the effects of a variety of therapies, such as those used to treat tinnitus, stroke, traumatic brain injury, post-traumatic stress disorder, speech deficit or language deficit.