An intravascular catheter includes a catheter shaft having a distal portion, a plurality of magnetic localization elements disposed within the distal portion, and an integrated electronics package disposed within the distal portion of the catheter shaft. The integrated electronics package, which can be a system on a chip such as an application specific integrated circuit, includes a power supply, a pre-amplifier, a multiplexor, and an imaging element driver. It can also include imaging elements. The magnetic localization elements can include magnetic coils and/or solid state magnetic localization elements, such as anisotropic magnetoresistive sensors, and can also be incorporated into the integrated electronics package.

A catheter includes a shaft having a lumen extending from a distal end to a proximal end. The shaft includes a reinforcement body including a plurality of wires that are disposed on at least a part between an inner surface of the shaft forming the lumen and an outer surface of the shaft and that are braided in a tubular shape, and at least one radiopaque marker disposed between the reinforcement body and the outer surface of the shaft. An outer diameter difference, which is a difference between an outer diameter of the shaft in a portion where the marker is disposed and an outer diameter of the shaft in a portion adjacent to the marker in an axial direction of the shaft, is smaller than twice a thickness of the marker.

The present invention relates to an elongated catheter comprising a tubular section with a side wall with essentially annular cross-section defined by an outer surface and an inner surface of the tubular section. In the outer surface of the tubular section, there is at least one longitudinal installation recess extending over a first predefined distance over the longitudinal dimension of the catheter. A flexible circuit board is wrapped around the tubular section. Electrical wiring is disposed on the outer surface of the tubular section. At least one electronic device is assembled on the flexible circuit board and disposed within the at least one longitudinal installation recess. The at least one electronic device is interconnected via the flexible circuit board with the electrical wiring.

This invention relates methods of using a non-fucosylated anti-CD40 antibody for treatment of cancer and chronic infectious diseases.

An intravascular heart pump assembly can include a rotor with at least one impeller blade, and a cannula. The present application describes various cannulas that can be manufactured from multiple layers of material to improve flexibility, manufacturability, and durability without increasing an outer diameter of the cannula. In one embodiment, the cannula includes an inflow section having a sheet formed of a shape memory material embedded within a polymer and having at least one lateral hole or aperture in the inflow section. The at least one lateral hole is defined by a first hole in the sheet and a second hole in the outer polymer layer of the cannula. The first hole and the second hole overlap so that blood can enter the cannula through the holes.

A catheter that does not require a fixing tool for fixing an end of a reinforcing body to an inner layer and does not require a separate marker to allow a user of the catheter to visually recognize a position of the catheter during procedures. The catheter includes a catheter main body having an inner layer that is a hollow tubular body, a braid that covers an outer periphery of the inner layer from a proximal end of the inner layer to a distal end of the inner layer, and an outer layer that covers an outer periphery of the braid. At least one end portion of the braid is folded under itself to form a folded part, and an end of the braid is in contact with the inner layer and is arranged in a lowest layer of the folded part.

Provided is a production apparatus capable of producing a flexible tube whose hardness is naturally varied along the length direction thereof. This mixing valve includes: a first valve configured to distribute a first resin to a resin supply path and a resin discharge path; and a second valve configured to distribute a second resin to the resin supply path and the resin discharge path. In the mixing valve, the mixing proportion between the first resin and the second resin is increased or decreased in association with molding of the flexible tube, by changing a distribution ratio of the first resin in the first valve and a distribution ratio of the second resin in the second valve while keeping constant the total of the supply mounts of the first resin and the second resin supplied to a die.

A catheter may include a distal side and a proximal side comprising a shaft having an outer tubular member, and an insertion member. The catheter may have at least a part of the insertion member in an axial direction disposed in the outer tubular member. At least one outer tubular member or insertion member is a multilayer tube having a first layer and a second layer laminated with the first layer. In a cross-section perpendicular to an axial direction of the multilayer tube, a ratio of cross-sectional areas of the second layer to the first layer is 0.7 or less.

An intermittent urinary catheter assembly 100 includes a reinforcement member 106 extending longitudinally at least partially within the distal end portion of the inner drainage lumen 104 of the catheter shaft. The reinforcement member may serve to connect a drainage member 114 to the catheter shaft and includes a drainage passageway in fluid communication with the inner drainage lumen of the shaft for allowing the drainage of urine through the urinary catheter assembly.

An enhanced flexibility catheter shaft having an elongate flexible body with a proximal end, a distal end, and at least one lumen extending therethrough. A distal, flexible section on the body has a ribbed or corrugated tubular membrane having at least a first reinforcement structure, such as a first helical support, on a radially exterior or interior surface of the membrane and optionally a second reinforcement structure, such as a second helical support, on the other of the radially interior or exterior surface of the membrane