A percutaneous heart valve delivery system including a valve delivery catheter coupled with a first inflatable balloon positioned at a distal end of the valve delivery catheter, wherein the first inflatable balloon is configured to fracture a previously implanted prosthetic heart valve; and a replacement transcatheter heart valve positioned proximal to the first inflatable balloon, wherein the replacement transcatheter heart valve is configured to be implanted subsequently within the previously implanted, fractured prosthetic heart valve, following fracture of the previously implanted heart valve without withdrawal of the percutaneous heart valve delivery system. Also disclosed are methods of implantation of a new heart valve within a previously implanted prosthetic heart valve and methods of valvuloplasty of a native heart valve.

A catheter comprising an elongated member having a distal end and a proximal end. The proximal end defines a drainage inlet extending from an external wall of the elongated member into the elongated member. The elongated member defines a first lumen that connects the drainage inlet with a drainage outlet defined by the distal end. The catheter also includes an inflatable retention balloon defined by the external wall of the elongated member and located between the drainage inlet and the drainage outlet. The catheter further includes a fluid inlet valve that protrudes from the elongated member and defines a second lumen that extends from the fluid inlet valve through the elongated member and to the inflatable retention balloon. The catheter additionally includes a secondary balloon that protrudes from the elongated member, the elongated member defining a third lumen that extends from the inflatable retention balloon to the secondary balloon.

Manifolds and methods of operating manifolds are provided. An example manifold for controlling multi-lumen devices is provided that includes a substance supply mechanism. The substance supply mechanism independently provides a substance to, or remove a substance from, each of a plurality of lumens. The example manifold also includes a lumen selection mechanism. The lumen selection mechanism selectively opens and closes a connection between the substance supply mechanism and at least one of the plurality of lumens. A corresponding method of operation is also provided. An example embodiment also includes a manifold for use with a vessel seclusion device.

The present invention relates to a pharmaceutical composition for intravascular delivery of a therapeutic agent, such as paclitaxel, rapamycin, or an analog thereof. The composition includes the therapeutic agent and a biocompatible solvent, such as glycofurol. The composition can aid tissue penetration by the therapeutic agent. A catheter assembly that protects the pharmaceutical composition from the surroundings can be used for its intravascular delivery.

The invention relates to medical technology, and more particularly to a device for the conservative treatment of nasal and paranasal sinus diseases. The present device comprises obturators for the posterior and anterior nasal openings, each obturator being in the form of an expandable sheath made of a resilient material and provided with a feed tube. The distal end of the tube is in communication with the cavity below the sheath, and the proximal end is provided with an adapter having a valve mechanism. The obturator sheath for the posterior nasal opening is hermetically fastened to the distal portion of its feed tube. The obturator sheath for the anterior nasal opening is hermetically fastened to a cuff. The cuff is provided with two channels, one of which holds the feed tube of the obturator sheath for the posterior nasal opening in such a way that the cuff can move along the entire length of the feed tube. The other channel holds a catheter for evacuating a pathological secretion from the paranasal sinuses and/or for introducing solutions of medicinal preparations into same for diagnostic or therapeutic purposes. The catheter is held in said channel in such a way that the distal portion thereof can be moved into the space between the obturator sheaths. The invention is intended to provide more effective treatment of nasal and paranasal sinus disorders.

Provided is a balloon with multiple small segments (balloons) fused to each other along the shaft of the balloon. Each segment has a different pressure profile. Each segment has a separate outlet (slot) used for its inflation with the required pressure according to the tightness and calcification of the lesion of the arterial wall. Each segment can be inflated with different pressures and the apposition of the overlying stent can be confirmed without the need for another non compliant balloon which carry many complications and add extra cost.

A treatment method includes: inserting a first closure and a second closure into a tubular organ, wherein the tubular organ includes at least one affected site; contacting an inner wall of the tubular organ with the first closure and the second closure to close the tubular organ with the at least one affected site located between the first closure and the second closure; with the tubular organ closed by the first closure and the second closure, aspirating a gas located in the tubular organ between the first closure and the second closure; and with the tubular organ closed by the first closure and the second closure, delivering a liquid medicine into the tubular organ between the first closure and the second closure.

A Luer-like non-standard quick disconnect medical fluid connector that cannot be engaged with a standard Luer fitting.

A method of implanting a prosthetic heart valve includes advancing a distal end portion of a catheter shaft through a patient's vasculature. The distal end portion of the catheter shaft includes an expansion device. A prosthetic heart valve is mounted on the expansion device with the expansion device and the prosthetic heart valve in a compressed configuration. The method further includes positioning the distal end portion of the catheter shaft and the prosthetic heart valve to an implantation location, and expanding the prosthetic heart valve and the expansion device from the compressed configuration to an expanded configuration. The expansion device includes an inner expandable member and a plurality of outer expandable members. The outer expandable members are distributed such that there are gaps providing perfusion passageways between the expansion device and the prosthetic heart valve when the expansion device is in the expanded configuration.

A device and system for thermally affecting tissue that includes a balloon catheter with a reduced distal length for ease of navigation and that also includes a balloon that is more resistant to bursting and delamination. The balloon may include a proximal neck generally attached to an elongate body and a distal neck generally attached to a shaft disposed within the elongate body. The distal neck is turned inward to extend within the balloon chamber and the proximal neck may either extend within the chamber or extend proximally away from the balloon chamber. Alternatively, the device may include an inner balloon and an outer balloon, the distal necks of both being turned inward and extending within the inner balloon chamber. The proximal necks may both also be turned inward to extend within the chamber or the proximal neck of the outer balloon may extend away from the balloon chamber.