A sterile closed intermittent urinary catheter system which is an easier to use by virtue of ergonomic shaping to facilitate advancement and retrieval of the catheter from the collection bag. The bag may have a closed internal hole adjacent an indent in one edge that creates a narrow channel through which the catheter passes. The narrow channel is located near to and in alignment with an outlet assembly so that the catheter extends from the narrow channel directly to the outlet. A user may easily grasp the catheter from outside the bag at the narrow channel and urge the catheter forward or backward to alternately extend and retract it through the outlet. A flexible pusher sleeve with gripper features may be added around the narrow channel to further facilitate catheter advancement.

A method to regulate patient gene expression by controllably circulating antisense oligonucleotide material (ASO) through a closed fluid circuit formed between the patient's ventricle and lumbar regions. To that end, after coupling a fluid channel between those regions, such embodiments add ASO to the fluid channel (preferably after the channel is primed with CSF) and energize a pump to controllably flow the CSF and the ASO mixed with the CSF. CSF/ASO fluid flow may be managed to localize treatment (e.g., providing deep brain distribution) while minimizing toxicity potentially caused by the ASO to certain nerves (e.g., the peripheral nerve).

An implantable drainage device is provided. The device is adapted to move body fluid from one part of the body of a patient to another part of the body.

A blood clot removal device for removing blood clots from the vascular system of a patient is implantable in the patient's body. The blood clot removal device comprises a blood flow passageway to be connected to the patient's vascular system to allow circulation of the patient's blood through the blood flow passageway, a filter provided in the blood flow passageway for collecting blood clots occurring in the blood flowing through the blood flow passageway, and a cleaning device for moving blood clots collected by the filter out of the blood flow passageway. By means of such blood clot removal device, the risk of blood clots reaching sensitive areas of the patient's body, such as the brain, is reduced.

A sterile closed intermittent urinary catheter system which is an easier to use by virtue of ergonomic shaping to facilitate advancement and retrieval of the catheter from the collection bag. The bag may have a closed internal hole adjacent an indent in one edge that creates a narrow channel through which the catheter passes. The narrow channel is located near to and in alignment with an outlet assembly so that the catheter extends from the narrow channel directly to the outlet. A user may easily grasp the catheter from outside the bag at the narrow channel and urge the catheter forward or backward to alternately extend and retract it through the outlet. A flexible pusher sleeve with gripper features may be added around the narrow channel to further facilitate catheter advancement.

Cerebrospinal fluid (CSF) and other fluid amelioration systems completely or partially implantable within a mammalian subject and associated methods include a substrate and an agent for amelioration of a toxic biomolecule present in the CSF or fluid, wherein the agent is disposed on or within the substrate.

The present disclosure relates to a peritoneal cavity-bladder connecting catheter for ascites drainage. The peritoneal cavity-bladder connecting catheter for ascites drainage includes a peritoneal cavity position part positioned on the side of a peritoneal cavity by passing through a bladder wall located between the peritoneal cavity and a bladder, the peritoneal cavity position part having inlets through which ascites flow into an inner space and being formed as a film that surrounds the inner space, and a bladder position part integrally formed with the peritoneal cavity position part and positioned on the side of the bladder located on the side of the bladder wall opposite to the peritoneal cavity, the bladder position part having outlets through ascites flowed into the peritoneal cavity position part are discharged to outside, and being configured to form a closed inner space together with the peritoneal cavity position part.

A medical drainage device for draining air or fluid from a body cavity is described for its use in treating a subject suffering from pneumothorax and/or pleural effusion. The device comprises a tube or a catheter-over-needle for receiving air or fluid from the body cavity and one or more fixation systems for preventing inadvertent dislodging of the needle and/or catheter during the draining procedure. A woven semi-flexible catheter coated with antithrombic agents is used for reducing kinks and clogs. The device may be used for draining air and/or fluid from a plurality of types of body cavities and is particularly suitable for uses in military and/or emergency settings.

The present invention relates to a filtering device for removing particles from a bodily fluid of a patient, the filtering device being implantable in the patient's body. The device has a tube forming a main fluid passageway for bodily fluid, through which the bodily fluid of the patient passes when the tube is implanted in the patient, a filter connected to the tube and a filter cleaning device for cleaning the filter by moving particles collected by the filter out of the fluid passageway, wherein the filter cleaning device is adapted to replace the first filter in the fluid passageway with a second filter, thereby moving the particles collected by the first filter out of the fluid passageway.

The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF) by removing target compounds from CSF. The systems provide for a catheter flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents.