An implantable body fluid drainage system includes a metering shunt having a housing with an internal chamber. A movable barrier divides the chamber into a first section and a second section, and the barrier can be displaced by a differential pressure. A first powered inlet valve providing a fill path to the first section of the chamber, and a first powered drain valve providing a drain path from the first section of the chamber. A CSF inlet conduit connects a CSF space to the first powered inlet valve. A CSF outlet conduit connects the first powered outlet valve to a discharge location. A controller opens the first powered inlet valve and close the first powered drain valve to fill the first section to a volume defined by the barrier and chamber geometry and closes the first powered inlet valve and opens the first powered drain valve to discharge the filled volume from the first section through the outlet conduit.

Filtering cassettes, filtering systems, and methods for using the same are disclosed. An example filtering cassette may include a cassette housing. An inlet may be coupled to the cassette housing. The inlet may be configured to receive cerebrospinal fluid from a catheter. An outlet may be coupled to the cassette housing. The outlet may be configured to direct filtered cerebrospinal fluid to the catheter. One or more filters may be disposed within the cassette housing. An arcuate surface may be defined along a periphery of the cassette housing. The arcuate surface may be configured to engage a controller assembly when the cassette housing is mounted to the controller assembly.

Implantable physiological shunt systems and related fluid flow control devices and accessories for use therewith. Devices, systems and methods relating to implantable medical fluid flow control devices, rotors and magnets with increased resistance to inadvertent setting changes. Devices, systems and methods relating implantable medical fluid flow control devices, rotors and magnets which provide improved magnetic coupling to fluid flow control device accessories such as adjustment tools.

An implantable cranial medical device includes a first fluid flow path, a second fluid flow path, and upper flange portion, and a lower portion. The upper flange portion is configured to rest on a skull of a subject about a burr hole. The lower portion is configured to be placed within the burr hole. The first fluid flow path may extend from a first opening in the upper flange portion to a first opening in the lower portion. The second fluid flow path may extend from a second opening in the upper flange portion to a second opening in the lower portion.

A method of managing cancer in a patient’s cerebrospinal fluid (“CSF”) forms a fluid circuit by fluidly communicating a set of catheters (“a catheter”) with the patient’s brain ventricle and the patient’s lumbar and, while controlling the flow rate of the CSF through the CSF fluid circuit, filters cancer cells from the CSF through the fluid circuit. The method also determines both a variable indicative of cancer cell concentration in the CSF, and at some point, that the variable has attained or passed through a threshold value (e.g., greater than a maximum threshold value or below a minimum threshold value). The method stops controlling the CSF flow rate in response to the variable attaining and/or passing through the threshold value. The CSF flow rate therefore preferably returns to a natural CSF flow rate of the patient after stopping control of the CSF flow rate. A system preferably performs these acts.

The present invention provides a skull implant-type automatic fluid drain device comprising: a body having a first port to be connected to a catheter, a second port provided opposite the first port, and a flow passage connecting the first port and the second port; a separation member for separating the flow passage into first and second sub-channels; a first valve fixed to the separation member and provided to allow the movement of a fluid that moves from the first port to the second port in the first sub-channel; and a second valve fixed to the separation member and provided to allow the movement of a fluid that moves from the second port to the first port in the second sub-channel, wherein each of the first valve and the second valve has an inflow end portion that is open and a discharge end portion provided in a closed state such that the same is selectively opened at an allowed opening pressure or higher; each of the first valve and the second valve is configured such that the inner flow sectional area decreases along the direction of allowed movement of the fluid passing through each of the inflow end portion and the discharge end portion; and the allowed opening pressures of the first valve and the second valve are set to differ from each other.

Disclosed is a system including a contact limiting portion. The system may include a flow regulating or shunt system, for various purposes. The system may include a limiting contact portion for extended use of the disclosed system.

Disclosed is a control system for a shunt system implantable in a subject. The control system may operate a selected portion of the shunt system, such as a flow control. The control system may operate the shunt system with a closed feedback loop based upon selected sensor input to achieve selected or optimal outcomes.

Disclosed is a system including a flow regulating system. The flow regulating system may assist in ensuring a selected pressure within an inlet volume. The flow regulator may be included in a shunt assembly.

A system includes a flow regulating system. The flow regulating system may assist in ensuring a selected pressure within an inlet volume. A flow regulator may be included in a shunt assembly (10).