Methods for treating hydrocephalus using a shunt, the shunt having one or more CSF intake openings in a distal portion, a valve disposed in a proximal portion of the shunt, and a lumen extending between the one or more CSF intake openings and the valve, the method comprises deploying the shunt in a body of a patient so that the distal portion of the shunt is at least partially disposed within a CP angle cistern, a body of the shunt is at least partially disposed within an IPS of the patient, and the proximal portion of the shunt is at least partially disposed within or proximate to a JV of the patient, wherein, after deployment of the shunt, CSF flows from the CP angle cistern to the JV via the shunt lumen at a flow rate in a range of 5 ml per hour to 15 ml per hour.

A gravitational pressure regulating valve to regulate fluid flow of a patient, including a fluid chamber having an inlet port to receive a bodily fluid and an outlet port to discharge received bodily fluid, the fluid chamber including a first chamber configured to capture a non-buoyant member therein and to guide the non-buoyant member along a longitudinal axis of the first chamber to facilitate bi-directional reciprocating movement of the non-buoyant member to and from the inlet port, and a second chamber configured to capture one or more buoyant members therein such that when the second chamber is filled with bodily fluid, at least one of the buoyant members applies a resolved buoyant pressure from a buoyant force of the one or more buoyant members in opposition to an inlet pressure of fluid at the inlet port.

Systems and methods for implanting an endovascular shunt in a patient is disclosed. The system having an expandable anchor configured for being deployed in a dural venous sinus of a patient at a location distal to a curved portion of a wall of an inferior petrosal sinus (IPS) of the patient; an elongate guide member coupled to, and extending proximally from, the anchor; a shunt delivery catheter having a first lumen configured to receive the guide member, and a second lumen extending between respective proximal and distal openings in the shunt delivery catheter, the shunt delivery catheter further having a penetrating element coupled to a distal end of the catheter; and the system further having a guard at least partially disposed over, and movable relative to, the penetrating element.

A locator as part of a toolkit for locating an implanted valve. The locator is used in concert with an indicator that nests therein. The locator has a lower ring with a contact surface, contacting a patient, a key positioning the nested indicator to prevent rotation, and a lower ring joint opposite the contact surface. Also included is an upper ring with an upper ring joint rotatingly interfacing with the lower ring joint, a flow direction identifier, and a flow setting identifier. Further, the upper and the lower rings rotate relative to each other, and the lower ring is floor-less.

A self cleaning inlet head for use on a shunt. The head has a tube with openings disposed in predetermined positions in its wall, and a cleaning element installed inside the tube. The cleaning element may comprise a central shaft with a number of bristles protruding therefrom, preferably in locations substantially identical to the positions of the openings in the wall of the tube. Mutual vibratory motion between the cleaning element and the tube causes at least some of the bristles to enter the openings, thereby keeping them clear, and preventing tissue growth into them. The vibratory motion may be generated by the action of an external field on a responsive part of the cleaning element, such as an external magnetic field operating on a magnetic or magnetized part of the cleaning element or the bristles. Alternatively, the external field may be an ultrasound field operating on the bristles.

Methods for treating hydrocephalus using a shunt, the shunt having one or more CSF intake openings in a distal portion, a valve disposed in a proximal portion of the shunt, and a lumen extending between the one or more CSF intake openings and the valve, the method comprises deploying the shunt in a body of a patient so that the distal portion of the shunt is at least partially disposed within a CP angle cistern, a body of the shunt is at least partially disposed within an IPS of the patient, and the proximal portion of the shunt is at least partially disposed within or proximate to a JV of the patient, wherein, after deployment of the shunt, CSF flows from the CP angle cistern to the JV via the shunt lumen at a flow rate in a range of 5 ml per hour to 15 ml per hour.

A shunt device for directing fluid from a human head, and methods thereof are provided herein. The device can be mounted at a skull and include a first catheter that extends into a portion of the head such as a lateral ventricle. The first catheter can covey fluid through, and past a valve to a shunt body. The shunt body can include openings, allowing the fluid to reenter the head, for example at the subarachnoid space. The shunt body can also include other openings that can be associated with a second catheter. Fluid can thus also be conveyed out of the body or to a subgaleal pocket.

Described herein is the use of CSF, more particularly external CSF or CSF-like compositions for the treatment and prevention of different diseases. More particularly, the application provides for the administration of CSF to the intrathecal space or the cerebral ventricles of a patient to increase intracranial pressure and/or CSF flow.

An adjustable hydrocephalus valve. The abstract of the disclosure is submitted herewith as required by 37 C.F.R. 1.72(b). As stated in 37 C.F.R. 1.72(b): A brief abstract of the technical disclosure in the specification must commence on a separate sheet, preferably following the claims, under the heading Abstract of the Disclosure. The purpose of the abstract is to enable the Patent and Trademark Office and the public generally to determine quickly from a cursory inspection the nature and gist of the technical disclosure. The abstract shall not be used for interpreting the scope of the claims. Therefore, any statements made relating to the abstract are not intended to limit the claims in any manner and should not be interpreted as limiting the claims in any manner.

Systems and methods for implanting an endovascular shunt in a patient is disclosed. The system having an expandable anchor configured for being deployed in a dural venous sinus of a patient at a location distal to a curved portion of a wall of an inferior petrosal sinus (IPS) of the patient; an elongate guide member coupled to, and extending proximally from, the anchor; a shunt delivery catheter having a first lumen configured to receive the guide member, and a second lumen extending between respective proximal and distal openings in the shunt delivery catheter, the shunt delivery catheter further having a penetrating element coupled to a distal end of the catheter; and the system further having a guard at least partially disposed over, and movable relative to, the penetrating element.