A device (1) for the application of liquid medical substances (100) comprises a main body (2) extending around a longitudinal axis (X) and comprising a housing portion (3) at a first open end (4) and a delivery portion (5) at a second open end (6) which is opposite the first (4); a hermetically sealed cartridge reservoir (7) containing a liquid medical substance (100); a perforating element (8) disposed inside the main body (2) in a position falling between the housing portion (3) and the delivery portion (5) and such as to achieve the perforation of one end of the cartridge reservoir (7). The perforating element (8) has a tubular shape and comprises, in a central portion thereof, a cylindrical conduit (12) having a cutting edge (14) faced towards the housing portion (3).

A non-laser tattoo removal method that includes the steps of cleaning and drying a target area on a user's skin, the target area including at least one tattoo disposed thereon; administering a deracination serum to the target area with a handheld automatic needle assembly having a plurality of needles after the cleaning and drying of the target area; wiping the target area with an absorbent material to remove an extracted pigmented material at least partially composing the tattoo; applying a malleable clay formulation material to cover the target area and leaving the malleable clay formulation material on the target area until forming a dried-on clay formulation; removing the dried-on clay formulation from the target area; and applying a liquid healing agent to the target area after removing the dried-on clay formulation from the target area and covering the liquid healing agent with at least one transdermal drug delivery sheet for selective removal by the user after a healing time period.

An opening structure including opening methods and elements to fracture a glass ampoule in a safe, secure, and friendlier manner at a specific point on the ampoule, which allows the ampoule to retain in place its substantial structure, allowing less glass fragments from the ampoule's breakage to obstruct the smooth, consistent, and speedy flow of the ampoule's substance to the opening structure's dispenser/applicator.

The present disclosure relates to the use of the sequiterpene lactones and Helenalin (H. tox) or its derivatives to treat viral infection and virally induced lesions, such as warts or wart-associated skin or mucosal lesion. A topical application, optionally using a skin covering such as gauze, a bandage, or a patch, can substantially reduce and even eliminate persistent, recurrent and/or treatment-resistant warts.

The present invention relates to a pharmaceutical foam composition comprising a corticosteroid and a Vitamin D analogue for topical administration to a patient in need thereof, such as for the treatment of plaque psoriasis. The present invention also relates to a process for preparing the composition and a suitable container system for administration of the composition. Preferably, the invention relates to the topical administration of betamethasone dipropionate and calcipotriene with one or more pharmaceutically acceptable excipients and propellants where the composition is stable in the container system coated with a coating material selected from the group comprising of epoxyphenol resin, modified polyesters, microflex coating or polyacrylates.

Medical adhesive applicators are disclosed which allow medical adhesives to have long storage life and be easily dispensed in a controlled manner. In one embodiment, the applicator has a frangible glass vial with the medical adhesive. The frangible glass vial is held in a plastic enclosure with a dispensing tip. Attached to the plastic enclosure is a squeeze tube capable of imparting air pressure into the enclosure. In another embodiment, the applicator has a proximal chamber containing medical adhesive, a distal chamber for dispensing medical adhesive and one or more rupturable membranes between them. In another embodiment, an applicator pad is sized to retain the total volume of adhesive and initiator so that, in use, the entire volume of adhesive liquid is first loaded into the pad. So loaded, the adhesive and initiator mix evenly to provide an adhesive layer that cures puddle-free.

A first ocular treatment kit comprises one or more sealed wrappers containing an applicator and a first ocular composition. The applicator includes a shaft and a swab, wherein the swab is coupled to a first end of the shaft. The swab is saturated with the first ocular composition inside the wrapper. The first ocular composition comprises polyaminopropyl biguanide, 1,2 hexanediol and caprylyl glycol. A second ocular treatment kit comprises a first sealed wrapper and a second sealed wrapper. The first sealed wrapper contains an applicator while the second sealed wrapper contains a second ocular composition. The second ocular composition comprises tea tree oil, tea tree oil, sea buckthorn oil and a medium chain triglyceride.

Various embodiments provide a package for containing and applying a substance. The package can include a handle layer, a carrier layer, an applicator, and an enclosing layer. The handle layer can include: a first handle portion; a second handle portion; and a joining portion. The carrier layer can include: a first surface; and a second surface. The joining portion of the handle layer can be connected to the first surface of the carrier layer. The applicator can contain the substance. The first handle portion and the second handle portion are configured to move from a first state to a second state, wherein, in the first state, the first handle portion and the second handle portion are parallel with the carrier layer, and, in the second state, the first handle portion and the second handle portion are not parallel to the carrier layer.

According to some embodiments, a skin treatment assembly comprises a handpiece comprising a distal end, the handpiece comprising a recess or cavity configured to receive a cartridge or other fluid container, a tip configured to be positioned along the distal end of the handpiece, the tip being configured to contact a skin surface of a subject during use, and at least one rollerball configured to extend to or near the tip, wherein the rollerball is configured to be in fluid communication with an interior of a cartridge or other fluid container secured to the handpiece, wherein the at least one rollerball is configured to contact the skin surface of the subject during use and to facilitate the delivery of fluids to said skin surface as the rollerball is moved relative to said skin surface.

An apparatus that includes a container portion and a coupler portion. The container and coupler are, in one embodiment, mated via an adapter that includes a one-way valve. The coupler includes a second one-way valve. In use, a fluid source, such as a vial, is connected to the coupler. An air source, such as a syringe is also connected to the coupler. Air from the syringe is introduced to the vial via the second one-way valve. The second one-way valve prevents fluid from the vial from being drawn into the syringe. Introduction of air from the syringe into the vial forces fluid from the vial into the container via the first one-way valve. The first one-way valve prevents the fluid from escaping the container.