Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

Methods for promoting hair growth, and needling devices for use with such methods, are provided. Certain of the methods include disruption of the skin with a powered needling device, followed by an administration of a hair growth-promoting agent.

Disclosed herein are drug delivery devices that can temporally and spatially deliver biologically active agents. An example drug delivery device includes a microneedle array comprising a plurality of microneedles on a surface of a substrate, each microneedle comprising a core comprising a hydrogel and a layer on a surface of the core. Also disclosed are methods of using the drug delivery device, and methods of making the microneedle array that includes a loading device.

A hair growth applicator for promoting the growth of hair follicles by applying hair growth liquid, comprising a handle having an internal chamber for containing said hair growth liquid, said handle having a channel running from said chamber to a distal end of said handle, a tip disposed at said distal end of said handle with a plurality of needles disposed on said distal surface of said tip, said distal surface having an opening, wherein said chamber is in fluid connection with said opening on said distal surface of said tip

A method for delivering therapeutics includes infusing a hydrogel with cannabis; and contacting the hydrogel infused with cannabis into a human which causes the controlled timed releasing of the cannabis with hydrophobic molecules to permeate through a lipid pathway.

A device includes a cartridge to contain a CBD or CGB solution; a laser or heat source coupled to the cartridge to release the CBD or CBG solution; and a variable voltage power source coupled to the laser or heat source to adjust heating temperature on the cartridge.

A medical device is operable to extend and/or retract elements suitable for a particular purpose. The elements are extended and/or retracted in response to a stress applied by way of stretching and/or retracting the device, among other methods. The elements may remain extended and/or retracted or may recoil back to an initial position upon the removal of the force. In various embodiments, the elements are used to treat or deliver treatment to a target site within a body.

The present invention relates to a cutting device comprising a manual gripping element (100) and a cutting assembly (200) that is positioned on one end of the gripping element (100) and comprises a punch (210) split into at least two cutting tips (220, 230), at least one of these tips (220, 230) being hinged on the gripping element (100) in order to be movable between a rest and cutting position in which the tips (220, 230) are adjacent and a working and injection position in which the tips (220, 230) are spaced apart, and urging means (250) designed to move each movable tip (220, 230) into the working position when these urging means (250) press against the skin.

A microneedle array has a plurality of microneedles, said microneedles being supported by a substrate. In order to improve the properties of the microneedle array, the substrate is in the form of a grid structure or comprises a grid structure.

Methods and compositions for stimulating hair growth are disclosed. Compositions for stimulating hair growth include two or more of hyaluronic acid, osteopontin, and another CD44 binding ligand. Methods for stimulating hair growth include administering such composition into the skin of a patient.