A method for manufacturing a fine hollow protruding article (1) according to the invention involves: a protrusion forming step of bringing a projecting mold part (11) that includes a heating means into contact from one surface (2D) side of a base sheet (2) including a thermoplastic resin, and, while softening, with heat, a contact section (TP) in the base sheet (2) where the projecting mold part (11) contacts the base sheet (2), inserting the projecting mold part (11) into the base sheet (2), to form a protrusion (3) that protrudes from the other surface (2U) side of the base sheet (2); a cooling step of cooling the protrusion (3) in a state where the projecting mold part (11) is inserted in an interior of the protrusion (3); and a release step of withdrawing the projecting mold part (11) from the interior of the protrusion (3) after the cooling step, to form the fine hollow protruding article (1).

A preparation delivery assembly includes: a first substrate, a second substrate, and at least two needles of different lengths. Two side walls are provided between the first and second substrates to define a first chamber. At least one first channel that is in communication with the first chamber is provided in the second substrate in a direction perpendicular to the second substrate. And the needles are arranged on a surface of the second substrate, and each needle is in communication with the first chamber to deliver the preparation. A third channel is provided in the first substrate in a direction perpendicular to the first substrate, and one end of the third channel is in communication with the first chamber so as to guide the preparation introduced from the other end of the third channel into the first chamber.

The present invention relates to a micro-needle (7; 8; 9) for the transdermal administration of active molecules and/or for the sampling of biological fluids. The micro-needle (7; 8; 9) is made of polymeric material through photolithography. A cavity is defined in the micro-needle (7; 8; 9).

The present invention further relates to a method for obtaining through photolithography at least one micro-needle (7; 8; 9) for the transdermal administration of active molecules and/or for the sampling of biological fluids. A photo-cross linking polymer is exposed in liquid phase to an energy radiation causing the hardening thereof. A photolithographic mask (1; 2) is interposed between the source of the energy radiation and the photo-cross linking polymer. The photolithographic mask (1; 2) is configured in a manner such to generate in the photo-cross linking polymer a peripheral shadow area, a central shadow area and a lighting area confined between the peripheral shadow area and the central shadow area.

The method according to this invention is aimed at obtaining a micro-needle (7; 8; 9) for the transdermal administration of active molecules and/or for the sampling of biological fluids which shows the peculiar characteristic of being hollow and which is manufactured by means of a single photolithography operation, thus avoiding the use of additional processing.

The present invention relates to a microneedle array and a method for manufacturing the same, the microneedle array comprising: a support; and a plurality of microneedles loaded with a solid-phase formulation which protrude from the upper portion of the support, wherein a liquid-phase formulation is applied or added dropwise onto an area of the upper portion of the support in which the microneedles are not formed, or in a case where one or more holes are formed in the support, the liquid-phase formulation is released, through the holes, onto the area of the upper portion of the support in which the microneedles are not formed.

A needle assembly for transdermal administration including a substrate having a first surface and a second surface opposite to the first surface, and fine needles projecting perpendicularly from the first surface. The substrate has grooves on at least one of the first surface and the second surface, and the grooves are formed such that the substrate is deformable following a surface shape of a skin to allow axes of the fine needles to extend in a direction normal to the surface of the skin.

A device for manufacturing microstructures including a permeable template, wherein the template comprises at least one recess for manufacturing the microstructures. In addition, the device comprises a vacuum-generating device connected to the template such that a vacuum is applied to at least one side of the template. Further, a method for filling a permeable template, wherein the template comprises at least one recess for manufacturing microstructures. The method comprises feeding the at least one substance to be filled in to the template as well as generating a vacuum on at least one side of the template

A core-shell microneedle system and a method of manufacturing the microneedle system provides a pulsatile drug delivery system which is programmed to release drugs/vaccines at predictable times using biodegradable polymers and with controllable dosages. This microneedle system can be fully embedded into the skin and then release drugs/vaccines as sharp bursts in a timely manner, similar to multiple bolus injections.

A microneedle chip and manufacturing method. The method comprises injecting, into a female mold, a fluid needle liquid, wherein forming cavities matching the shapes of needles of a microneedle chip are provided at the female mold and form a cavity array, injection inlets are provided at a surface of one side of the female mold, and air ejection openings are provided at a surface of another side of the female mold to form an air ejection surface; covering the air ejection surface of the female mold using a breathable film, and during injection, passing a gas through the breathable film so as to retain the liquid inside the forming cavities; curing the fluid needle liquid to form the microneedle chip, and demolding to obtain the same. By employing the air ejection openings and the breathable film, a liquid is retained while ejecting a gas, providing a favorable micro-injection effect.

A microneedle-sheet packaging body includes a microneedle sheet, a forming sheet, and a support body. The microneedle sheet includes a substrate, and a plurality of microneedles formed on a lower surface of the substrate. The forming sheet is tightly adhered to the lower surface of the substrate. The forming sheet includes a plurality of micro-recess parts in which the plurality of microneedles are housed. The support body is fixed to an upper surface of the substrate of the microneedle sheet and is further fixed to the forming sheet around the substrate. Thus, the microneedle-sheet packaging body protects a plurality of microneedles on the microneedle sheet.

Provided is a method of manufacturing a microneedle array in which an active ingredient is concentrated at a tip while an active ingredient content is guaranteed. In order to achieve the object, a method of manufacturing a microneedle array in which needle-like recessed portions of a mold are filled with a liquid to form one dose of a patch includes determining a filling amount of the liquid from a difference in mass of the mold before and after filling of the liquid, determining a filling state of the liquid in the mold filled with the liquid, sucking the mold in which the filling amount and the filling state of the liquid are determined to be normal from a rear face, and evaporating and drying a solvent of the liquid of the sucked mold.