The present invention relates to a preparation method for a microneedle patch. Specifically, the present invention provides a preparation method for a microneedle patch, and the method comprises steps: (1) milling a base into a master mold of the microneedle patch; (2) conducting surface treatment on the master mold, to obtain the treated master mold; (3) conducting reverse molding on a surface of the treated master mold, conducting deaeration, curing, and demolding, to obtain the cured daughter mold; and (4) casting the modification solution on the surface of the daughter mold, and then conducting deaeration, drying and curing, to obtain the microneedle patch. The method for preparing the microneedle patch in the present invention can greatly reduce the milling difficulty, and save the milling cost and time. The microneedle molds with different aspect ratios, areas and shapes can also be prepared as required, following with reverse molding to diverse microneedle patches. Therefore, a feasible implementation scheme is provided in present invention for the production application of the microneedles and the feasibility of the wide application is greatly enhanced.

Microneedle, in particular for transdermal and/or intradermal active ingredient delivery, having a support structure and having at least one needle structure arranged on the support structure for penetrating the horny cell layer of human and/or animal skin, characterized in that at least the needle structure is produced by 3D screen printing.

An implantable substance delivery vehicle of the present invention comprises: a pin comprising a bevel tip and an engraved groove on the surface of the bevel tip; and a substance to be delivered into the body, inserted so as so as to protrude outwardly from the tip, wherein, when the implantable substance delivery vehicle is used for implantation, the substance to be delivered into the body, inserted so as so as to protrude, is caught in tissue so as to be readily detached.

Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface. The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage with a surface. In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components.

A tattoo needle structure is provided. A tattoo needle has a plurality of needle tips, an ink holding space is formed by the arrangement of the needle tips, and a multi-component alloy film is deposited on each needle tip of the tattoo needle by sputtering technology, so that when the tattoo needle is dipped into the tattoo ink, the tattoo ink does not stick to the surface of the multi-component alloy film by the hydrophobic property of the multi-component alloy film, and the tattoo ink is contained in the ink holding space by the cohesive property of the tattoo ink. Thus, when the tattoo needle is dipped into the tattoo ink and the tattoo process is performed, the dyeing area of the skin with the tattoo ink is the cross-sectional area of the ink holding space, thereby achieving the technical effect of improving the contouring resolution of a tattoo.

There is provided a microneedle patch. The microneedle patch includes: a plurality of microneedles each having an upper end portion and a base portion and which are individualized from each other; and a base layer that is formed of a water-soluble material and includes linear portions that pass the base portions of the microneedles neighboring each other among the plurality of microneedles and are joined to the base portions of the microneedles neighboring each other.

A balloon catheter which is inflated after insertion into a tubular tissue includes: a balloon catheter body made of a polymer material, which is inflatable by fluid injection; and a plurality of microneedles formed on the surface of the balloon catheter body, wherein the microneedles are formed by transferring a biocompatible polymer resin or photocurable resin, filled in intaglio patterns formed on a mold, which have a shape corresponding to a shape of the microneedles, to the surface of the balloon catheter body which is in close contact with the mold, by a thermal molding, thermal crosslinking or photocuring process.

The present invention discloses an anti-hair loss and hair growth integrated core-shell microneedle patch, comprising a backing and a core-shell microneedle array attached to one side of the backing, the core-shell microneedle array comprises a plurality of microneedles arranged on the backing to form an array, each microneedle comprises a shell substrate material and an internal core, and the shell substrate material is loaded with nano-enzyme for removing excessive active oxygen. The present invention uses an anti-hair loss and hair growth integrated core-shell microneedle patch of the above mentioned structure, wherein the shell substrate material is rapidly degraded after the microneedle patch is applied to the skin, the nano-enzyme loaded by the shell substrate material can be passively released to remove active oxygen and promote angiogenesis in the microenvironment around hair follicles, the internal core of the microneedle is loaded with mesenchymal stem cell-derived exosomes, and the internal exosomes are released and conveyed to hair follicle niches after the shell substrate material is degraded, so that improvement of pigmentation and promotion of hair regrowth are possible.

A microneedle array unit including a microneedle array having a plurality of needle-like protrusions arranged on one surface thereof, a gripping portion provided on a side opposite to the plurality of needle-like protrusions of the microneedle array, and a container configured to accommodate the microneedle array. The container includes an accommodation portion having an opening, a deformable portion disposed on a side opposite to the opening, and a binding portion provided in the accommodation portion of the deformable portion and bound to the gripping portion of the microneedle array. The deformable portion is deformed by receiving an external force in a direction of the opening and presses the microneedle array through the gripping portion, and the microneedle array is pushed out of the accommodation portion by being pressed, and the deformable portion maintains a deformed state and presses the microneedle array.

The present disclosure relates to a soluble microneedle and a filler composition with an excellent anti-wrinkle effect. Using the microneedle according to the present disclosure, crosslinked hyaluronic acid (hyaluronic acid filler material) can be intradermally or subcutaneously administered by a simple method, and a swelling property of the crosslinked hyaluronic acid is improved after administration, thereby exhibiting the excellent anti-wrinkle effect.