Provided herein is a system including a pre-filled syringe with a barrel defining a chamber containing a solution therein and a fluid connector component at the distal end of the barrel. A plunger assembly including a plunger and a stopper is movable within the barrel, with the plunger including a channel extending along a length thereof. An access device is positioned at the proximal end of the plunger and includes a receiving cavity and a fluid access component, the receiving cavity having an opening aligned with the channel and the fluid access component positioned over the opening and extending into the receiving cavity. A cannula is positioned within the barrel and extends through the stopper, the cannula placing the fluid connector component in fluid communication with the channel. A closure assembly is secured to the fluid connector component and includes a seal member configured to seal off a lumen thereof.

Embodiments of the invention are directed to flush syringe assemblies comprising an integrated contamination-prevention device integrated with device connector flushing positioned so that the practitioner cannot forget to apply disinfectant. The flush syringe assemblies comprise a barrel with an elongate plunger rod disposed therein and a cap comprising a passageway. The plunger rod includes a stopper of which at least a portion can be embedded in the passageway of the cap to form a plug in the cap.

A method and medical pump to perform a flushing procedure are provided. The medical pump is configured to execute the flushing procedure subsequent to an infusion procedure, the flushing procedure and infusion procedure lacking a specified relationship between each other until after performance of the infusion procedure. The method comprises performing an infusion procedure of a medicament with the medical pump and automatically querying in human detectable form whether to execute a flushing procedure in response to conclusion of the infusion procedure.

The present invention relates to a valve arrangement for use in an extracorporeal blood circuit having at least one arterial blood line and at least one venous blood line, the valve arrangement having at least one first valve arranged in the arterial blood line, a second valve arranged in the venous blood line, a fourth valve arranged in a first arteriovenous connection line between the arterial blood line of the circuit and the venous blood line of the circuit, and a fifth valve arranged in a second arteriovenous connection line between the arterial blood line and the venous blood line; and/or a third valve arranged for establishing a fluid connection in a blood line between the arterial blood line and the venous blood line of the circuit; and/or a sixth valve arranged between a blood treatment device and an air venting device of the circuit.

Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked. Systems and methods for flushing a shunt system are also disclosed herein, as are various systems and methods for opening auxiliary fluid pathways through a shunt system.

Disclosed herein are devices and methods related to UV disinfection of a transfer catheter during peritoneal dialysis. The transfer catheter comprises a first and second end, the second end comprising a transfer valve. The transfer valve body comprises an inlet, outlet, and a flush hole. The valve core comprises a notch configured to allow fluid flow between the various flow paths. The valve core and body are positioned off axis with respect to the fluid flow path. The transfer catheter can allow for a small volume kill zone, which can minimize the amount of UV required to disinfect the catheter.

Systems and methods of micro-infusion of medical fluids are disclosed. Micro-infusion systems may include a pump, a patient interface, tubing between the pump and the interface, and a micro-infusion device along the tubing. A first portion of the tubing above the micro-infusion device is longer than a second portion of the tubing below the device. The micro-infusion device may include a chamber in-line with the tubing, a first valve between the chamber and the first portion of the tubing, a second valve between the chamber and the second portion of the tubing and a third valve between the chamber and a dump chamber. The second valve may be slidably disposed within the chamber. A medical fluid may be provided into the chamber that slides the second valve displacing another fluid in the chamber through the third valve into the dump chamber.

Systems and methods are provided for intermittent microinfusion. A system may include a pump and an IV set that includes a y-port valve disposed below a pump interface portion of the IV tubing. The y-port valve may include an internal valve member that allows fluid to flow from the pump to a patient when no syringe is attached to the y-port. The internal valve member may be moved by the attachment of a syringe containing the medication to be infused to the y-port such that the fluid pathway from the pump to the patient is blocked and fluid from the syringe can be injected into the IV tubing between the y-port valve and the pump. The pump may retrograde pump the medication into the tubing via the y-port valve and then forward pump the medication to the patient when the syringe is removed from the y-port.

Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked. Systems and methods for flushing a shunt system are also disclosed herein, as are various systems and methods for opening auxiliary fluid pathways through a shunt system.

A flush syringe with a syringe coupler facilitates twice dispensing of intravenous flushing solution to a patient's vascular access device (VAD), with reduced risk of VAD infection. The syringe coupler incorporates a female, first Luer connector on its proximal end that is removably coupled to the male, barrel Luer connector of the syringe, isolating the latter connector from external contamination. The syringe coupler also has a single-use, male, second Luer connector on its distal end of the housing that is adapted for coupled insertion into the patient's VAD, for delivery of at least a portion of the flushing solution retained within the syringe. After the first delivery, the syringe coupler is de-coupled from both the VAD and the syringe. Thereafter, the syringe's unused, sterile, male, barrel Luer connector is directly coupled to the VAD for dispensing the second portion of the flushing solution.