An aspiration system exhibits an accelerated drop in negative pressure at the distal end of an aspiration catheter from the time of opening a valve. The system includes an aspiration pump in communication with a first chamber, and an aspiration catheter configured for placement into fluid communication with the first chamber by way of an elongate aspiration tube. A second chamber is provided between the aspiration tube and the catheter, and a valve is provided between the second chamber and the aspiration catheter. Upon opening of the valve with negative pressure at equilibrium in the first and second chambers, resistance to fluid flow between the second chamber and the distal end of the catheter is less than the resistance to fluid flow between the second chamber and the first chamber, causing a rapid aspiration into the second chamber.

A system for providing vascular access in a patient's body may comprise at least one hemostatic valve (610) and at least one clamp (210) to be used with a vascular graft (110). The vascular graft (110) comprises a tubular body having a proximal end (110A) and a distal end (110B), the proximal end (110A) being configured to be attached to a vessel in a patient's body. The at least one valve (610) is configured to be attached to the distal end (110B) of the graft's tubular body and comprises a housing (616) including a flexible membrane (611) that allows a medical device (810) to be inserted through the membrane (611) into said vascular graft (110). The valve (610) further comprises an introducer sheath (615) configured to be inserted into the distal end (110B) of the graft's tubular body. The at least one clamp (210) is configured to be disposed around the graft's tubular body and has a first configuration that allows insertion of the valve's introducer sheath (615) into the distal end (110B) of the graft's tubular body and a second configuration that allows clamping of the graft (110) against the valve's introducer sheath (615), when inserted in the graft's tubular body.

A guide wire capable of exhibiting improved penetrability for penetrating a stenosis without degradation of passing performance of the guide wire. A guide wire includes a wire main body formed into a linear shape, a distal end portion of the wire main body is formed into a curved shape by a top portion that forms an extreme distal portion and a surrounding portion that makes the top portion continuous with a peripheral surface of the wire main body, a plurality of recesses are formed in the distal end portion, and the recesses are formed in the top portion and the surrounding portion, respectively.

A guide wire capable of exhibiting improved penetrability for penetrating a stenosis without degradation of passing performance of the guide wire. A guide wire includes a wire main body formed into a linear shape, a distal end portion of the wire main body is formed into a curved shape by a top portion that forms an extreme distal portion and a surrounding portion that makes the top portion continuous with a peripheral surface of the wire main body, a plurality of recesses are formed in the distal end portion, and the recesses are formed in the top portion and the surrounding portion, respectively.

A balloon catheter including an elongated catheter main body portion and a balloon provided on the distal portion of the catheter main body portion. The balloon is inflatable to expand radially outward into an inflated state and deflatable to contract radially inward into a deflated state. The catheter main body portion includes a hollow outer tube and a hollow inner tube disposed within the outer tube. The balloon includes a contact portion that contacts the outer surface of the inner tube and a vane portion protruding from the contact portion radially outward when the balloon is in the deflated state. The contact portion of the balloon includes a connecting portion that connects the balloon to the catheter main body portion.

A balloon catheter including an elongated catheter main body portion and a balloon provided on the distal portion of the catheter main body portion. The balloon is inflatable to expand radially outward into an inflated state and deflatable to contract radially inward into a deflated state. The catheter main body portion includes a hollow outer tube and a hollow inner tube disposed within the outer tube. The balloon includes a contact portion that contacts the outer surface of the inner tube and a vane portion protruding from the contact portion radially outward when the balloon is in the deflated state. The contact portion of the balloon includes a connecting portion that connects the balloon to the catheter main body portion.

Mechanical thrombectomy systems including an elongate catheter configured as an elongate inversion support, a flexible tractor configured to roll and invert over the distal end of the elongate inversion support, and a clot engaging member on the distal end of an elongate manipulator are described herein. These systems may capture a clot using the clot engaging member and draw the clot and clot engaging member and roll the flexible tractor into the catheter to remove the clot and clot engaging member from a vessel.

A catheter assembly includes a catheter adapter and an introducer needle. The introducer needle extends through the catheter adapter and through a catheter tube so as to assist placement of the catheter tube into a patient's blood vessel. Blood flashback into the catheter tube and/or catheter adapter through an aperture in a side of the needle indicates when the catheter tube is within the blood vessel. After the catheter tube is placed in the blood vessel, the introducer needle is withdrawn. A primary septum within the catheter adapter blocks blood flow in a proximal direction past the primary septum. A secondary septum proximal the primary septum is biased so as to enter into the aperture in the introducer needle and plug the aperture while the needle is being withdrawn, thus blocking blood flow through the aperture after the aperture is drawn through the primary septum.

To provide a chemical ablation device that enables simple performance of chemical ablation treatment including pre- and post-treatment potential measurements. A chemical ablation device according to the present invention includes an electrode-equipped guidewire (30) with which intracardiac potential is measurable, an over-the-wire balloon catheter (40) having a guidewire lumen (415) into which the electrode-equipped guidewire (30) is to be inserted, a Y-shaped connector (50) connected to a proximal side of the balloon catheter (40) and including a guidewire port (51) and an expansion port (53), and a hemostasis valve (60) connected to the guidewire port (51) of the Y-shaped connector (50) and including a side-infusion tube (65) for supplying ethanol to the guidewire lumen (415) of the balloon catheter (40). The ethanol supplied to the guidewire lumen (415) of the balloon catheter (40) is ejected from an opening of a distal tip (47).

To provide a chemical ablation device that enables simple performance of chemical ablation treatment including pre- and post-treatment potential measurements. A chemical ablation device according to the present invention includes an electrode-equipped guidewire (30) with which intracardiac potential is measurable, an over-the-wire balloon catheter (40) having a guidewire lumen (415) into which the electrode-equipped guidewire (30) is to be inserted, a Y-shaped connector (50) connected to a proximal side of the balloon catheter (40) and including a guidewire port (51) and an expansion port (53), and a hemostasis valve (60) connected to the guidewire port (51) of the Y-shaped connector (50) and including a side-infusion tube (65) for supplying ethanol to the guidewire lumen (415) of the balloon catheter (40). The ethanol supplied to the guidewire lumen (415) of the balloon catheter (40) is ejected from an opening of a distal tip (47).