Apparatuses and methods are disclosed for anesthetizing a dental patient during dental procedures such as a root canal. Administering an anesthetic directly into the jaw bone of a patient, called intraosseous injection, is highly effective but can have a relatively short duration. In addition, a dental dam is often placed over the tooth being treated in order to control the environment. The apparatuses and methods disclosed herein permit an anesthetic to be delivered multiple times to the dental patient without removing or disturbing the dental dam.

A deagglomerator for use in resizing masses of cells is disclosed. The deagglomerator may include a plurality of apertures defined by a plurality of front and back edges. The masses of cells may be passed through the plurality of apertures from the front to the back, and from the back to the front, repeatedly. The deagglomerator may also include a plurality of blades that may aid in the deagglomeration of the cell masses. The deagglomerator may be configured between two syringes so that the tissue may be passed back and forth from the first syringe through the device to the second syringe, and then back again from the second syringe through the device and to the first syringe. In this way, the masses of cells may be properly deagglomerated.

An adaptor for connecting a drug delivery device to a needleless access device having a straight external thread, including engagement means for mounting said adaptor on the drug delivery device, and an internal thread intended to cooperate with said external thread on a determined length, said internal thread showing on a distal part of said length a first major diameter mating that of said straight external thread, wherein said internal thread shows on a proximal part of said length a second major diameter, where the second major diameter is strictly smaller than the first major diameter, said internal thread further including a tapered portion linking said proximal part to said distal part.

Systems, devices, and methods for treating a patient are disclosed. The systems can include a cryotherapy apparatus for selectively treating targeted tissue. The cryotherapy apparatus includes one or more stress relief couplings located along a conduit to help keep an applicator positioned at a treatment site without significant rotational torque being imparted to the applicator by the conduit so that the applicator does not tend to move relative to patient skin during a tissue treatment. The stress relief couplings can include swivel connectors and clamps that cooperate to minimize or limit a rotational force exerted on the applicator by the conduit after the applicator is applied to the patient's skin.

A two-part enteral connector system having first and second parts. The first part has a housing with an internal fluid flow passageway and the housing further includes external thread elements and a tip projection portion. The second part also has a housing with an internal fluid flow passageway and mating internal thread elements and resilient internal sealing surface area such that the first part is threadably engageable with the second part in an ISO 80369-3 thread compatible connection to form a liquid tight sealable engagement between the two parts such that the joined fluid flow passageways provide a high flow fluid flow passageway in excess of the 2.95 mm flow path of the existing ISO 80369-3 enteral small-bore connector flow path.

A cannula hub includes a shaft mount segment and a cannula coupling segment. A set of coupling nubbins radially extend from the outer surface of the cannula coupling segment. The coupling nubbins are aligned with one another along a helical cannula coupling pathway on the outer surface and are adapted to be received within a cooperative helical groove on a transfer vessel. The coupling nubbins have a protrusion projection distance that is greater than the depth of the groove. When a sufficient rotational force is applied to the cannula hub, the coupling nubbins score the inside face of the groove which increases the groove depth and enables the coupling nubbins to advance along the groove while forming a tight compression fit of the coupling nubbins within the groove.

The fluid delivery devices, systems and methods described herein include a subcutaneous port, a catheter, and a connection assembly configured to fluidly couple the port and catheter.

A catheter system may include a catheter assembly, which may include a catheter adapter and a catheter extending distally from a distal end of the catheter adapter. The catheter system may also include a needle assembly, which may include a needle hub and an introducer needle. The needle hub may include: a distal end coupled to the proximal end of the catheter adapter; a proximal end; a wall disposed between the distal end of the needle hub and the proximal end of the needle hub; and a flashback chamber proximate the wall. The introducer needle may be press-fit within a through-hole of the wall. The catheter system may also include a plug coupled to the proximal end of the needle hub. A blood collection device may be coupled to a proximal end of the plug to collect blood from a patient.

A combined bio-artificial liver support system, includes branch tubes that are connected in sequence: a blood input branch tube, an upstream tail end, a first plasma separation branch tube comprising at least a first plasma separator, a non-biological purification branch tube comprising at least a plasma perfusion device and a bilirubin adsorber, a biological purification branch tube comprising at least a hepatocyte culture cartridge assembly, and a plasma return branch tube, a downstream tail end of which is set as a blood output end.

A connector for connecting a first medical line to a second medical line is disclosed. This connector comprises an insertion shaft (12) having a flow channel that is intended to be brought into fluid communication with a lumen of a first medical line (3); a collar (10) that circumferentially extends around the insertion shaft (12), wherein the collar (10) comprises a first thread (100) on an inner side that faces the insertion shaft (12); and an elastic member (14) that is placed between the insertion shaft (12) and the collar (10), wherein the elastic member (14) comprises an abutment portion (141) abutting a surface of the insertion shaft (12) and being displaceable relative to the surface of the insertion shaft (12). The collar (10) is radially movable around the insertion shaft (12) and the elastic member (14) comprises a thread portion (142) having a second thread that engages the first thread (100) of the collar (10) such that a rotational movement of the collar (10) around the insertion shaft (12) results in a lateral displacement of the elastic member (14) along the surface of the insertion shaft (12). Furthermore, a method for operating such a connector is disclosed. Additionally, a connector assembly comprising such a connector is disclosed.