A vascular access device may include a housing, which may include a proximal end, a distal end, and a slot. The distal end of the housing may be configured to be coupled to a catheter assembly. The vascular access device may also include an instrument disposed within the housing. The instrument may include a catheter or a probe. The instrument may include a proximal end and a distal tip. The proximal end of the instrument may extend through the slot and may be configured to move along the slot to move the instrument from a proximal position to a distal position. In response to movement of the proximal end of the instrument from the proximal position to the distal position, the catheter may be advanced beyond the distal end of the housing into the catheter assembly and/or vasculature of a patient.

Described herein are systems and methods for performing peritoneal dialysis. According to one aspect, the disclosure provides a sterile interface connection for connecting a water purification system to a disposable source of dialysate concentrates. The sterile interface connection can include a chamber comprising an inlet adapted to be connected to the water purification system on a proximal end and a valve on a distal end. The sterile interface connection can also include spring-loaded needle disposed in the chamber. The spring-loaded needle can move between a retracted configuration in which the spring-loaded needle is fully retracted into the chamber and the valve is closed and sealed, and an extended configuration in which the spring-loaded needle extends through the valve into the disposable source of dialysate concentrates.

A fluid handling cassette, such as that useable with an automated peritoneal dialysis (APD) cycler device or other infusion apparatus, may include a generally planar body having at least one pump chamber formed as a depression in a first side of the body and a plurality of flowpaths for a fluid that includes a channel. A patient line port may be arranged for connection to a patient line and be in fluid communication with the at least one pump chamber via at least a first one of said flowpaths, and an optional membrane may be attached to the first side of the body over the at least one pump chamber. In one embodiment, the membrane may have a pump chamber portion with an unstressed shape that generally conforms to the depression of the at least one pump chamber in the body and is arranged to be movable for movement of the fluid in a useable space of the at least one pump chamber. One or more spacers may be provided in the at least one pump chamber to prevent the membrane from contacting an inner wall of the at least one pump chamber. The patient line, a drain line, and/or a heater bag line may be positioned to be separately occludable in relation to one or more solution lines that are connectable to the cassette.

Various embodiments include a locking catheter splice assembly that may include a multi-stage barb fitting, a first locking member, and a second locking member. The multi-stage barb fitting may have a first end including a first set of barbs and a second end including a second set of barbs. The first end may be configured to be inserted into the first catheter and the second end may be configured to be inserted into the second catheter. The first locking member may be slipped over the first catheter so as to surround the portion of the first end of the multi-stage barb inserted into the first catheter. The second locking member may be slipped over the second catheter so as to surround the portion of the second end of the multi-stage barb inserted into the second catheter. The first and second locking members may interlock with one another when pressed together.

A tamper-resistant device for holding a portion of an access port of a fluid line can include a first housing member that includes a first recess and a first stopping shelf. The device can further include a second housing member that includes a second recess and a second stopping shelf. The second housing member can couple with the first housing member such that the first and second stopping shelves cooperate to retain the portion of the access port within the device. The device can include a locking mechanism configured maintain the first and second housing members in a coupled state when engaged. The device can further include a tamper-evident indicator that, when activated, permits the first and second housing members to transition from the coupled state to a decoupled state to permit access to the access port of the fluid line.

A coupler may include a coupler body including a first end, a second end, an outer surface, an inner surface defining a cavity, and a wall defined between the inner and outer surfaces, a plurality of first retaining fingers disposed adjacent to the first end and extending radially inward into the cavity, and a mounting aperture defined between a free end of each first retaining finger and the wall. The cavity may be configured to receive a first connector and a second connector. The plurality of first retaining fingers may be radially biased inward toward the cavity and configured to engage against a collar of the first connector to prevent axial motion of the first connector relative to the coupler. The mounting aperture may be configured to receive a pivot shaft of the collar to pivotally couple the first connector relative to a central axis of the coupler body.

A fluid handling cassette, such as that useable with an automated peritoneal dialysis (APD) cycler device or other infusion apparatus, may include a generally planar body having at least one pump chamber formed as a depression in a first side of the body and a plurality of flowpaths for a fluid that includes a channel. A patient line port may be arranged for connection to a patient line and be in fluid communication with the at least one pump chamber via at least a first one of said flowpaths, and an optional membrane may be attached to the first side of the body over the at least one pump chamber. In one embodiment, the membrane may have a pump chamber portion with an unstressed shape that generally conforms to the depression of the at least one pump chamber in the body and is arranged to be movable for movement of the fluid in a useable space of the at least one pump chamber. One or more spacers may be provided in the at least one pump chamber to prevent the membrane from contacting an inner wall of the at least one pump chamber. The patient line, a drain line, and/or a heater bag line may be positioned to be separately occludable in relation to one or more solution lines that are connectable to the cassette.

A connector assembly may include a cover defining a cavity, a luer portion extending through an open end of the cover, a proximal connector disposed at least partially in the cavity of the cover, a pusher mounted on the proximal connector, a distal connector at least partially disposed in the cover, and a stopwatch mounted on the cover and including at least one contact. The pusher may include a body portion and first and second pusher legs extending from the body portion. When the distal connector is coupled to a mating connector, the stopwatch may abut the first pusher leg such that the at least one contact is recessed within the stopwatch. When a force applied to the proximal connector exceeds a predetermined threshold the stopwatch may be separated from the first pusher leg and the at least one contact may extend proximally to activate a timer of the stopwatch.

A medical treatment system, such as a peritoneal dialysis system, may include a control and other features to enhance patient comfort and ease of use. For example, a cycler device may include a heater bag receiving section and a lid mounted to cover and uncover the heater bag receiving section, potentially enabling faster heating of a dialysate. A user interface may be moveable to be received into the receiving section and covered by the lid, if desired. The system may detect anomalous conditions, such as tilting of a housing of the system, and automatically recover without terminating a treatment. The system may include noise reduction features, such as porting pneumatic outputs to a common chamber, and others. The system may also automatically detect any one of several different solution lines connected to the system, and control operation accordingly, e.g., to mix solutions provided by two or more lines and form a needed dialysate solution. A cassette control surface may be arranged to have one or more ports that can detect a presence of a liquid, e.g., to identify if a cassette is leaking or has otherwise been compromised.

A medical connector can include a body having a fluid path with an inlet port, an outlet port, a luer portion, and a post extending through a fluid path. An arm having a latch member is coupled to the body to engage a ridge or thread on an exterior surface of a reciprocal connector. The arm may also include an extension. When the connector is in an open position, the latch member restricts retraction of the reciprocal connector from the outlet port. A seal is coupled to the body and includes a flap extending across the outlet port or a bellows to compress along an axis. In a closed position, the post restricts flow through the luer portion. In an open position, the post permits flow through the luer portion.