A drug delivery system for injecting a medicament may include a housing defining a cavity, a container received within the cavity and configured to receive a medicament with the container including a closure, a valve assembly received within the cavity and including a piercing member configured to pierce the closure of the container, and a connector arrangement provided between the container and the valve assembly, the connector arrangement movable between a first, pre-use position maintaining sterility between the closure of the container and the valve assembly and a second, use position permitting fluid communication between the container and the valve assembly.

A housing includes a cavity portion and a cover portion configured for rotary motion. The cover portion can include a receiver port configured to engage with a fitting configured for coupling to an end of a first tube. At a first alignment position of the cavity portion relative to tire cover portion, the receiver port is aligned with a first retention cleat. At a second alignment position of the cavity portion relative to the cover portion, the receiver port is aligned with a fluid coupler. At a third alignment position of the cavity portion relative to the cover portion, the fitting is aligned with a second cap.

A fitting assembly includes a fitting and a tube. The fitting has a fitting body having a straight through hole and an attachment or base port, connected to the through hole by a first passageway generally perpendicular to the through hole. The tube has an outer diameter smaller than the through hole allowing a first end of the tube to pass through the through hole. A seal is positioned in one of a circumferential slot in the tube and a circumferential slot in the through hole of the fitting body, the seal sealing a second end of the tube to the fitting body. A cover is sealingly attached to the first end of the through hole. One of the cover and the tube has a portion that extends into an intersection of the through hole and the first passageway, the portion having an aperture that prevents blockage between the attachment or base port and the second end of the through hole.

An IV disposable time indication device includes one of a tube and a slot containing a volume of gel, wherein the gel is configured to evaporate at a determined rate of time upon activation by exposure to ambient air. A seal is configured to prevent contact of the gel with ambient air. One or more time indicators are disposed on the device, wherein evaporation of the gel is configured to provide a visual indication of a passage of time after activation. Methods of operating an IV disposable time indication device are also provided.

An IV disposable time indication device includes one of a tube and a slot containing a volume of gel, wherein the gel is configured to evaporate at a determined rate of time upon activation by exposure to ambient air. A seal is configured to prevent contact of the gel with ambient air. One or more time indicators are disposed on the device, wherein evaporation of the gel is configured to provide a visual indication of a passage of time after activation. Methods of operating an IV disposable time indication device are also provided.

A sterile connector includes a first section of tubing with a first end portion to be connected to a second end portion of a second section of tubing and/or another counterpart to establish fluid communication. An axial protrusion extends away from the first end portion of the first section of tubing in an axial direction, and a separation layer closes off an inside of the section of tubing. The separation layer has a predetermined breaking site, and the axial protrusion is connected pivotally to the first end portion of the first section of tubing to pivot from a first position to a second position when engaged with a second axial protrusion and/or with the other counterpart and is coupled to the separation layer to exert a breaking force on the separation layer in the second position.

Modular fluid path assemblies are provided that include conduit, coupling, and needle portions of a fluid path fluidly coupled to an outlet of a container. The modular fluid path assemblies further include a needle shield having a tip of the needle embedded therein. So configured, in embodiments, the modular fluid path assemblies can be sterilized, a medicament can be filled in the container, and a stopper inserted in the container so that the pre-sterilized and pre-filled modular fluid path assemblies can have a closed container integrity (CCI) seal.

Modular fluid path assemblies are provided that include conduit, coupling, and needle portions of a fluid path fluidly coupled to an outlet of a container. The modular fluid path assemblies further include a needle shield having a tip of the needle embedded therein. So configured, in embodiments, the modular fluid path assemblies can be sterilized, a medicament can be filled in the container, and a stopper inserted in the container so that the pre-sterilized and pre-filled modular fluid path assemblies can have a closed container integrity (CCI) seal.

A method is described for opening a heat bonded sterile connection that includes a skin of material blocking flow between the connection site. The method includes applying external pressure to the connection site.

Fluid access devices include a machine-side hydraulic circuit and a patient-side hydraulic circuit, and are configurable between a connected state and at least one disconnected state. In the connected state, fluid flows between the machine-side hydraulic circuit and the patient-side hydraulic circuit. In the disconnected state, fluid does not flow between the machine-side hydraulic circuit and the patient-side hydraulic circuit. In some disconnected states, fluid recirculates through at least one of the machine-side hydraulic circuit or the patient-side hydraulic circuit in the disconnected state.