A connector system for medical fluid administration has a female connection member, which can act as an access port for a container of medical fluid, and a male connection member, for accessing the container of medical fluid. The female connection member defines a sheath for receiving a portion of the male connection member and this sheath is spanned at one end by a septum, which acts to close the container of medical fluid. A lumen is defined through the male connection member to allow passage of fluid therethrough. The septum has a central region and a peripheral region, the central region being of substantially greater thickness than the peripheral region. The male connection member comprises means for rupturing the peripheral region of the septum when it is received in the female connection member to form a connection.

Some embodiments disclosed herein relate to a medical connector having a backflow resistance module configured to prevent fluid from being drawn into the connector when a backflow inducing event occurs. In some embodiments, the backflow resistance module can include a variable-volume chamber configured to change in volume in response to a backflow-inducing event and a check valve configured to resist backflow. In some embodiments, the medical connector can include a fluid diverter configured to direct fluid flowing through the medical connector into the variable volume chamber to prevent fluid stagnation therein. In some embodiments, the medical connector includes a body member, a base member, a seal member, a support member, and a valve member.

One aspect of the invention provides a system including: a cannula and a valve. The valve includes: a first port coupled to the cannula; a second port adapted and configured for coupling to tubing; a third port comprising a resilient pierceable seal; and a central cylindrical plug received between the first port, the second port, and the third port. The central plug includes a through-channel adapted and configured to selectively couple two of the ports. In a first position, the first port, the third port, and the through-channel are coupled such that a dilator can pass: from outside the rotary valve; through the pierceable seal; through the first port; and out a distal end of the cannula. In a second position, the first port and the second are port are fluidically coupled.

Some embodiments disclosed herein relate to medical connectors with a housing comprising a proximal body member and a base member that form an internal cavity with a proximal abutment surface. An elastomeric seal without a guide member is positioned within the internal cavity. A rigid, hollow elongated portion is located within the internal cavity such that in an open configuration, a tip of the elongated portion is more proximal than a proximal surface of the elastomeric seal. A distal portion of the elastomeric seal is seated radially within a region surrounded by a plurality of longitudinally extending protrusions.

A fluid control component configured for controlling fluid flow through the hub of a catheter assembly during and after placement into the patient is disclosed. In one embodiment, the fluid control component comprises a body disposed within a cavity of the hub, the body being movable between a first position and a second position, wherein the body does not pierce a valve disposed in the hub when in the first position and wherein the body pierces the valve when in the second position. The body includes a conduit to enable fluid flow through an internal portion of the body when the body is in the second position, and a plurality of longitudinally extending ribs disposed on an exterior surface of the body. The ribs provide at least one fluid flow channel between the valve and an external portion of the body when the body is in the second position.

A connector system for medical fluid administration has a female connection member, which can act as an access port for a container of medical fluid, and a male connection member, for accessing the container of medical fluid. The female connection member defines a sheath for receiving a portion of the male connection member and this sheath is spanned at one end by a septum, which acts to close the container of medical fluid. A lumen is defined through the male connection member to allow passage of fluid therethrough. The septum has a central region and a peripheral region, the central region being of substantially greater thickness than the peripheral region. The male connection member comprises means for rupturing the peripheral region of the septum when it is received in the female connection member to form a connection.

The present invention extends to a blood control catheter valve for use in a catheter adapter. The blood control catheter value employs an actuator for bypassing a septum to open the blood control catheter valve. The actuator includes flexible retention arms positioned on one end which retract into the body of the actuator while the end of the actuator passes through the septum, and then expand outwardly to maintain the actuator positioned within the septum. This design facilitates the manufacturing of catheter adapters (as well as blood control catheter valves and other components that attach to the catheter adapter) because the design can reduce the tolerance requirements of such components. Further, the design provides a reliable blood control catheter valve that does not require the catheter adapter to be increased in size to accommodate the valve.

A syringe adapter is provided. The adapter includes a housing having a first end and a second end positioned opposite the first end. The housing may include a first portion and a second portion connected to the first portion. The first end of the housing can include a connector configured to be secured to a syringe barrel. The adapter also includes a cannula positioned within the housing and a seal arrangement including a membrane positioned within the housing and movable within the housing. The first portion of the housing can be connected to the second portion via axial and radial interference between the first portion and the second portion of the housing.

A solution is proposed for closing a mouth (125) of a container (110) of a liquid (105). A corresponding closure (135) comprises a cap (205) having fixing means (315) for fixing the cap (205) to the container (110), a delivery port (321) for delivering the liquid (105) from the container (110), a valve member (215) in a closed position wherein the valve member (215) closes the delivery port (321), a cap suction conduit (339) for suctioning air into the container (110) during the delivering of the liquid (105) and a connector (327) for connecting to a delivery device (805) of the liquid (105), the connector (327) being in fluid communication with the delivery port (321), a slider (220) slidebly coupled with the cap (205), the slider (220) having a slider suction conduit (440) for suctioning the air into the container (110) during the delivering of the liquid (105) slidebly coupled with the cap suction conduit (339), and a frangible element (345) closing the cap suction conduit (339) or the slider suction conduit (440), wherein the closure (135) is configured to cause the delivery device (805) during the connecting thereof to move inwards the container (110), in a fixed condition wherein the closure (135) is fixed to the container (110), and thus moving the valve member (215) inwards the container to an open position, wherein the valve member (215) opens the delivery port (321), and moving the slider (220) inwards the container to break the frangible element (345), thereby putting in fluid communication the slider suction conduit (440) with the cap suction conduit (339).

A device for providing an implanted injection site capable of delivering a therapeutic substance or medication into the subarachnoid space. The receiving compartment is implanted under the skin adjacent the spine. Injections may be made repeatedly into the membrane for delivering the therapeutic substance without the need for repeated spinal taps. Medications such as immunoglobulin may be administered intrathecally directly into the central nervous system bypassing the blood brain barrier providing more concentrated, effective and less costly treatment of diseases such as Alzheimer's disease. Another embodiment is a method of administering an immunoglobulin composition having a four to six percent concentration incrementally over time by alternately removing cerebrospinal fluid and injecting the immunoglobulin composition.