Disclosed herein is an implantable blood pump assembly that includes a housing defining an inlet, an outlet, and a flow path extending from the inlet to the outlet, a rotor positioned within the flow path, a stator positioned within the housing and operable to drive the rotor, and an outflow cannula. The outflow cannula includes a coupler assembly configured for removable mechanical connection to the outlet coupler, and includes a first component of an anti-rotation mechanism and a first component of an axial lock. The housing includes an outlet coupler that includes a second component of the anti-rotation mechanism and a second component of the axial lock. The first and second components of the anti-rotation mechanism are positioned to engage one another prior to the first and second components of the axial lock during insertion of the outflow cannula into the housing outlet.

Disclosed herein is an implantable blood pump assembly that includes a housing defining an inlet, an outlet, and a flow path extending from the inlet to the outlet, a rotor positioned within the flow path, a stator positioned within the housing and operable to drive the rotor, and an outflow cannula. The outflow cannula includes a coupler assembly configured for removable mechanical connection to the outlet coupler, and includes a first component of an anti-rotation mechanism and a first component of an axial lock. The housing includes an outlet coupler that includes a second component of the anti-rotation mechanism and a second component of the axial lock. The first and second components of the anti-rotation mechanism are positioned to engage one another prior to the first and second components of the axial lock during insertion of the outflow cannula into the housing outlet.

Apparatus and methods are described including a left-ventricular assist device that includes an impeller (50) and a frame (34) disposed around the impeller (50). The frame (34) includes strut junctions (33) at a proximal end of the frame, the strut junctions (33) being configured to be maintained in open states, during assembly of the left ventricular assist device, to facilitate insertion of the impeller (50) into the frame (34). A securing element (117) holds the struts junctions in closed states, subsequent to the insertion of the impeller (50) into the frame (34). A pump-outlet tube (24) extends to a distal end of the frame (34) and defines one or more lateral blood inlet openings (108) that are configured to allow blood to flow from the subject's left ventricle into the pump-outlet tube (24). Other applications are also described.

A blood pump system for persistently increasing the overall diameter and lumen diameter of peripheral veins and arteries by persistently increasing the speed of blood and the wall shear stress in a peripheral vein or artery for a period of time sufficient to result in a persistent increase in the overall diameter and lumen diameter of the vessel is provided. The blood pump system includes a blood pump, blood conduit(s), a control system with optional sensors, and a power source. The pump system is configured to connect to the vascular system in a patient and pump blood at a desired rate and pulsatility. The pumping of blood is monitored and adjusted, as necessary, to maintain the desired elevated blood speed, wall shear stress, and desired pulsatility in the target vessel to optimize the rate and extent of persistent increase in the overall diameter and lumen diameter of the target vessel.

To provide a simple embodiment of a rotor for a fluid pump which is nevertheless very flexible in handling and compressible, in accordance with the invention a conveying blade is provided having at least two struts and a membrane spanned between them in the expanded state, wherein the struts each have at least one joint, in particular more than one joint, which enables an angling in a first direction in a first movement plane and bounds an overelongation beyond an elongation angle of in particular 180° in the opposite second direction. In particular when a plurality of joints are provided at the struts, they, and with them the conveying blades, are particularly flexible for simple compressibility.

To provide a simple embodiment of a rotor for a fluid pump which is nevertheless very flexible in handling and compressible, in accordance with the invention a conveying blade is provided having at least two struts and a membrane spanned between them in the expanded state, wherein the struts each have at least one joint, in particular more than one joint, which enables an angling in a first direction in a first movement plane and bounds an overelongation beyond an elongation angle of in particular 180° in the opposite second direction. In particular when a plurality of joints are provided at the struts, they, and with them the conveying blades, are particularly flexible for simple compressibility.

Improvements in fluid volume measurement systems are disclosed for a pneumatically actuated diaphragm pump in general, and a peritoneal dialysis cycler using a pump cassette in particular. Pump fluid volume measurements are based on pressure measurements in a pump control chamber and a reference chamber in a two-chamber model, with different sections of the apparatus being modeled using a combination of adiabatic, isothermal and polytropic processes. Real time or instantaneous fluid flow measurements in a pump chamber of a diaphragm pump are also disclosed, in this case using a one-chamber ideal gas model and using a high speed processor to obtain and process pump control chamber pressures during fluid flow into or out of the pump chamber.

The invention concerns a control device for controlling a blood flow of an intravascular blood pump for percutaneous insertion into a patient's blood vessel, the blood pump comprising a pump unit with a drive unit for driving the pump unit and configured to convey blood from a blood flow inlet towards a blood flow outlet, wherein the control device is configured to operate the blood pump in a selectable zero-flow control mode, wherein a blood flow command signal is selected, and the control device comprises a first controller and a second controller, wherein the first controller is configured to control the blood flow by adjusting a speed command signal for the drive unit, and the second controller is configured to control a drive speed of the drive unit.

The invention concerns a control device for controlling a blood flow of an intravascular blood pump for percutaneous insertion into a patient's blood vessel, the blood pump comprising a pump unit with a drive unit for driving the pump unit and configured to convey blood from a blood flow inlet towards a blood flow outlet, wherein the control device is configured to operate the blood pump in a selectable zero-flow control mode, wherein a blood flow command signal is selected, and the control device comprises a first controller and a second controller, wherein the first controller is configured to control the blood flow by adjusting a speed command signal for the drive unit, and the second controller is configured to control a drive speed of the drive unit.

Blood pump devices having improved rotary seals for sealing a bearing assembly supporting a rotor provided herein. Such rotary seals are particularly suited for use in blood pump devices that include rotors having cantilevered supported through a sealed mechanical bearing disposed outside a blood flow path of the device to avoid thrombus formation caused by blood contact with the bearing. The rotary seal can include a first and second face seal that are preloaded with a deflectable compliance member incorporated into the pump housing or a pair of magnets. Such rotary seals can instead or further utilize tight fitment between components or a bio-absorbable fill material to seal an interface between the rotor shaft and pump housing to seal the bearing assembly from fluid flowing through the pump.