The described invention is a hyperthermia and hyperoxygenation medical apparatus for treating diseases of the blood and purification of stored blood supplies. The invention comprises a hollow chamber through which blood is made to flow. Within the hollow chamber are a heating element and a gas diffuser. As blood flows through the chamber, blood is heated to a preset limit while ozone or other beneficial gas is diffused into the blood by a diffuser with pores to a preset concentration. After heating and gasification, blood exits the hollow chamber and is either returned to the patient or returned to storage. The hollow chamber, heating element and gas diffuser are designed to maintain efficient, linear blood flow through the invention, in part by taking advantage of die radial symmetry of the hollow chamber and diffuser designs. Linear flow ensures uniform and controlled heating and gasification of the blood with negligible undesirable turbulence to the blood components.

A system for generating nitric oxide can include an apparatus positioned in a trachea of a mammal, the apparatus including a respiration sensor for collecting information related to one or more triggering events associated with the trachea, an oxygen sensor for collecting information related to a concentration of oxygen in a gas, and one or more pairs of electrodes for initiating a series of electric arcs to generate nitric oxide, and the system for generating nitric oxide can also include a controller for determining one or more control parameters based on the information collected by the respiration sensor and the oxygen sensor, wherein the series of electric arcs is initiated based on the control parameters determined by the controller.

In some additional aspects, an apparatus can include a chamber having an inlet valve for receiving a reactant gas and an outlet valve for delivering a product gas, a piston positioned inside the chamber and configured to move along a length of the chamber for adjusting pressure in the chamber, a sensor for collecting information related to one or more conditions of a respiratory system associated with a patient, a controller for determining one or more control parameters based on the collected information, and one or more pairs of electrodes positioned inside the chamber for initiating a series of electric arcs external to the patient to generate nitric oxide based on the determined control parameters.

The present disclosure is generally related to systems, methods and devices for providing ozone treatment of multiple medical devices including passageways. In particular the systems, methods and devices may attach to multiple medical devices and clean, disinfect and/or sterilize the inner space of the tubes, including the areas most prone for bacteria buildup. A multi-channel ozone treatment device has an ozone operating system and a distribution line that splits into a plurality of distribution channels to distribute ozone to a plurality of ozone ports in a gas-tight compartment. A multi-port connector unit for connecting to a plurality of passageways in the gas-tight compartment is further disclosed.

The present disclosure is generally related to devices, methods and systems for cleaning, disinfecting and/or sterilizing a medical device, medical hoses and tubes and accessories thereof with ozone gas, in particular the disclosure relates to devices, methods and systems with multiple receptacles for providing closed-loop fluid pathways to distribute ozone gas to inner passageways and the outer compartments of medical devices. The devices in accordance with an embodiment of the disclosure have two or more receptacles for distributing ozone gas, a gas-tight compartment, an ozone operating system, and one or more connector units configured to fluidly migrate ozone in closed-loop treatment systems.

Devices, systems, and methods for medication infusion are described herein. In some embodiments, a system includes a patient access subassembly, a first fluid reservoir, a second fluid reservoir, and an assembly. The assembly can have a first configuration in which the patient access subassembly is in fluid communication with the first fluid reservoir via a first tube, a second configuration in which the first fluid reservoir is in fluid communication with the second fluid reservoir, and a third configuration in which the first fluid reservoir is in fluid communication with the patient access subassembly via a second tube, the first fluid reservoir fluidically isolated from the first tube in the third configuration.

The present disclosure is generally related to devices, methods and systems for cleaning, disinfecting and/or sterilizing a medical device, medical hoses and tubes and accessories thereof with ozone gas, in particular the disclosure relates to devices, methods and systems with multiple receptacles for providing closed-loop fluid pathways to distribute ozone gas to inner passageways and the outer compartments of medical devices. The devices in accordance with an embodiment of the disclosure have two or more receptacles for distributing ozone gas, a gas-tight compartment, an ozone operating system, and one or more connector units configured to fluidly migrate ozone in closed-loop treatment systems.

A system for generating nitric oxide can include an apparatus positioned in a trachea of a mammal, the apparatus in eluding a respiration sensor for collecting information related to one or more triggering events associated with the trachea, an oxygen sensor for collecting information related to a concentration of oxygen in a gas, and one or more pairs of electrodes for initiating a series of electric arcs to generate nitric oxide, and the system for generating nitric oxide can also include a controller for determining one or more control parameters based on the information collected by the respiration sensor and the oxygen sensor, wherein the series of electric arcs is initiated based on the control parameters determined by the controller.

Oxygen-charged (or oxygen-rich) implantable medical devices for and methods of local delivery of oxygen via outgassing is disclosed. The presently disclosed oxygen-charged implantable medical devices are, for example, polymeric implants that are functionalized to locally deliver oxygen from the implant surface for prolonged periods of time, thus increasing rates of healing and reducing rates of infection as compared with conventional medical implant devices.

Technologies (e.g., devices, systems and methods) for sanitizing positive airway pressure (PAP) systems are described. In some embodiments, the technologies include a PAP delivery system comprising a hose and a PAP mask, a positive pressure supply system configured to generate a flow of pressurized air which is delivered to a user through the hose to the PAP mask of the PAP delivery system, a sanitizing system configured to sanitize one or more components of the self-sanitizing PAP system, and a PAP base unit housing, wherein one or more components of the positive pressure supply system and the sanitizing system are disposed at least partially within the PAP base unit housing.