A method of delivering a substance, such as one or more of a triptan, a nasal steroid or carbon dioxide gas, to the nasal cavity of a subject, in particular for the treatment of headaches, for example, migraine, or rhinosinusitis, for example, chronic rhinosinusitis, optionally with polyps, the method comprising the steps of fitting a nosepiece to one nostril of the subject, delivering the substance through the nosepiece to the posterior region of the nasal cavity of the subject.

A patient interface device includes a frame having a central portion with a patient facing side, an opposite outward facing side, a first plurality of magnetic elements secured on or in the patient facing side, and a first aperture defined therethrough. The first aperture having a first portion extending from the outward facing side toward the patient facing side which is structured to be coupled to a delivery conduit and a patient side portion defined by a wall which extends outward from the patient facing side forming a hub. The device further includes a cushion having a patient contacting side which is structured to sealingly engage about an orifice or orifices of a patient, an opposite frame contacting side including a second aperture defined therein which is sized and configured to engage about the hub, and a second plurality of magnetic elements for magnetically coupling the cushion to the frame.

A patient interface device includes a frame having a central portion with a patient facing side, an opposite outward facing side, a first plurality of magnetic elements secured on or in the patient facing side, and a first aperture defined therethrough. The first aperture having a first portion extending from the outward facing side toward the patient facing side which is structured to be coupled to a delivery conduit and a patient side portion defined by a wall which extends outward from the patient facing side forming a hub. The device further includes a cushion having a patient contacting side which is structured to sealingly engage about an orifice or orifices of a patient, an opposite frame contacting side including a second aperture defined therein which is sized and configured to engage about the hub, and a second plurality of magnetic elements for magnetically coupling the cushion to the frame.

A cushion assembly for a patient interface includes an elastomeric seal-forming portion with a dome-shaped superior region that is intersected by the sagittal plane in the vicinity of a superior tangent point. The seal-forming portion further including a saddle-shaped inferior region that is intersected by the sagittal plane and includes an inferior tangent point. A first support region is located on one side of the sagittal plane between the inferior region and the superior region, the exterior surface of the elastomeric seal forming portion at the first support region being cylinder-shaped and/or saddle-shaped. In addition, a blowout prevention system is configured to counter a force acting on the unsupported edge of the elastomeric seal-forming portion due to a pressure within the chamber, the blowout prevention system being attached to the elastomeric seal-forming portion at the first support region of the elastomeric seal-forming portion.

A patient interface may include a plenum chamber and a positioning and stabilising structure. The plenum chamber may include a seal-forming structure and a fascia portion. At least a medial portion of the fascia portion is flexible. In embodiments, the patient interface may include a rigidiser to control flexing of the fascia portion.

A patient interface may include a plenum chamber and a positioning and stabilising structure. The plenum chamber may include a seal-forming structure and a fascia portion. At least a medial portion of the fascia portion is flexible. In embodiments, the patient interface may include a rigidiser to control flexing of the fascia portion.

A patient interface includes a frame assembly including connectors operatively attachable to headgear, a cushion assembly provided to the frame assembly and including a seal-forming structure structured to form a seal with the patient's nose and/or mouth, and an air delivery connector provided to the frame assembly and operatively connected to an air delivery tube for supplying the air at positive pressure along an air flow path. The cushion assembly is structured to releasably connect to the frame assembly independently of the air delivery connector. The air delivery connector is structured to releasably connect to the frame assembly independently of the cushion assembly.

A patient interface includes a frame assembly including connectors operatively attachable to headgear, a cushion assembly provided to the frame assembly and including a seal-forming structure structured to form a seal with the patient's nose and/or mouth, and an air delivery connector provided to the frame assembly and operatively connected to an air delivery tube for supplying the air at positive pressure along an air flow path. The cushion assembly is structured to releasably connect to the frame assembly independently of the air delivery connector. The air delivery connector is structured to releasably connect to the frame assembly independently of the cushion assembly.

Various embodiments of a metered dose inhaler that includes a metering valve are disclosed. The inhaler includes a reservoir containing a pressurized formulation of medicament and carbon dioxide. The metering valve includes a metering chamber, a metering valve stem, and a metering valve stem seal having an opening through which the metering valve stem passes to form a dynamic seal between the metering valve stem and outside atmosphere. The metering valve stem seal has a Shore D hardness of 45 to 80 and its opening is adapted to be stretched wider by the metering valve stem passing through it than it would be absent the valve stem.

A patient interface comprises a seal-forming structure including a textile membrane and a support structure to support the textile membrane. The seal-forming structure may have a varying construction in order to accommodate different regions and the varying contours of the patient's face to ensure a robust and comfortable seal. An air impermeable layer of the textile membrane may have a thickness that varies in different portions of the textile membrane and/or different regions of the cushion assembly. Further, the seal-forming structure may include an underlying cushion, and an arrangement of the textile membrane and the underlying cushion and/or the configuration of the underlying cushion may vary in different regions of the cushion assembly to optimize patient comfort and the effectiveness of the seal in different regions of the patient's face.