A portable gas delivery system 10 may generally comprise a gas container 20, a regulator 30, an adapter 40 to couple the regulator 30 to the container 20, and a tube or cannula 50 and/or a mask 60 fluidly connected to the container 20. Methods of making and using the portable gas delivery system are also described.

This disclosure relates to methods and apparatus for treating diseases and conditions of the colon and alimentary canal which are associated with obligate anaerobic microorganisms, and particularly, for treating Clostridioides difficile infection. The method and apparatus provide for continuous administration of intraluminal oxygen to the rectum, colon, and cecum to maintain oxygen in those environments at levels toxic to obligate anaerobic microorganisms such as Clostridioides difficile.

This disclosure relates to methods and apparatus for treating diseases and conditions of the colon and alimentary canal which are associated with obligate anaerobic microorganisms, and particularly, for treating Clostridioides difficile infection. The method and apparatus provide for continuous administration of intraluminal oxygen to the rectum, colon, and cecum to maintain oxygen in those environments at levels toxic to obligate anaerobic microorganisms such as Clostridioides difficile.

In one embodiment, the present invention provides a system to deliver at least one therapeutic gas to a spontaneously breathing patient, wherein the rate of delivery of the at least one therapeutic gas exceeds the patient's inspiratory flow rate, and the amount of the at least one therapeutic gas that is wasted is minimized or eliminated.

The systems and methods include providing, displaying, and/or utilizing leak estimation during ventilation of a patient with a ventilator. The systems and methods include providing, displaying, and/or utilizing internal leak estimation, total leak estimation, and/or external leak estimation during ventilation of a patient with a ventilator.

An example aerosol delivery device includes a mouthpiece having an airflow outlet, and an airflow passage extending between an airflow inlet and the airflow outlet. The example aerosol delivery device further includes a housing configured to receive a cartridge that includes an aerosolizable substance and a vapor element configured to heat the aerosolizable substance, and an internal power source configured to provide electrical power. The example aerosol delivery device further includes a controller coupled to the internal power source to receive a portion of the electrical power and configured to, when the cartridge is installed at the housing, cause the vapor element of the cartridge to heat the aerosolizable substance to release an aerosol into the airflow passage during an inhalation through the airflow outlet, and a connector configured to receive power from an external source to recharge the internal power source.

The present invention provides a method and apparatus for controlling a patient's body temperature and in particular for inducing therapeutic hypothermia. Various embodiments of the system are described. The system includes: a source of breathing gas, which may be in the form of a compressed breathing gas mixture; a heat exchanger or other heating and/or cooling device; and a breathing interface, such as a breathing mask or tracheal tube. Optionally, the system may include additional features, such as a mechanical respirator, a nebulizer for introducing medication into the breathing gas, a body temperature probe and a feedback controller. The system can use air or a specialized breathing gas mixture, such as He/O.sub.2 or SF/O.sub.2 to increase the heat transfer rate. In addition, the system may include an ice particle generator for introducing fine ice particles into the flow of breathing gas to further increase the heat transfer rate.

A filter for an apparatus for delivering a flow of gas, the filter comprising: a filter body, wherein the filter body has a main compartment and a sub-compartment at least partly within the main compartment, wherein the main compartment is in fluid communication with a main compartment gases inlet and the sub-compartment is in fluid communication with a sub-compartment gases inlet; and a filter medium associated with both the main compartment and the sub-compartment, and that is arranged to filter gases in, or exiting, the main compartment and the sub-compartment.

A filter for an apparatus for delivering a flow of gas, the filter comprising: a filter body, wherein the filter body has a main compartment and a sub-compartment at least partly within the main compartment, wherein the main compartment is in fluid communication with a main compartment gases inlet and the sub-compartment is in fluid communication with a sub-compartment gases inlet; and a filter medium associated with both the main compartment and the sub-compartment, and that is arranged to filter gases in, or exiting, the main compartment and the sub-compartment.

The present invention relates to low concentration synergistic Xenon-Argon gas mixtures argon for use in a method for preventing and/or treating ischemic insults, wherein —the volume proportion of xenon is between 5 and 20%; —the volume proportion of argon is between 5 and 20%; and —the pharmaceutical composition further comprises a gas complement to reach 100% volume proportion; —the method includes comprises restoration of blood flow and the gas mixture is administered to the patient before, during, or after blood flow restoration.