The invention relates to a dialysis machine having an extracorporeal blood circuit, a blood pump, a dialyzer, a venous pressure sensor, a substituate line, and a control unit, wherein the control unit is configured to operate the blood pump in a first operating mode and in a special operating mode and to start the special operating mode after recognition of a trigger event, in which special operating mode a conveying rate of the blood pump is controlled by means of a default value or is regulated to a desired value, which default or desired value is derived from a value determined before the start of the currently started special operating mode or corresponds to said value, wherein the presence of at least one obstacle is polled before the start of the special operating mode, and wherein, on the presence of the obstacle, the start of the special operating mode is blocked or delayed and/or the selection of the default value or of the desire value on the presence of the obstacle differs from the selection without the presence of the obstacle.

The invention relates to a dialysis machine having an extracorporeal blood circuit, a blood pump, a dialyzer, a venous pressure sensor, a substituate line, and a control unit, wherein the control unit is configured to operate the blood pump in a first operating mode and in a special operating mode and to start the special operating mode after recognition of a trigger event, in which special operating mode a conveying rate of the blood pump is controlled by means of a default value or is regulated to a desired value, which default or desired value is derived from a value determined before the start of the currently started special operating mode or corresponds to said value, wherein the presence of at least one obstacle is polled before the start of the special operating mode, and wherein, on the presence of the obstacle, the start of the special operating mode is blocked or delayed and/or the selection of the default value or of the desire value on the presence of the obstacle differs from the selection without the presence of the obstacle.

An air purging method includes: (a) detecting a low fluid level in a blood circuit indicating a high amount of air in the blood circuit; (b) stopping a blood pump; (c) closing a venous patient line; (d) opening a blood circuit air vent valve and a drain valve; and (e) running the blood pump to meter air through the air vent valve and the drain valve to a drain.

A method for the re-anticoagulation of platelet rich plasma in a blood apheresis system includes priming the blood apheresis system with anticoagulant, such that a volume of anticoagulant is transferred to a PRP container. The method may then transfer the anticoagulant within the PRP container to a red blood cell container, and collect a volume of platelet rich plasma within the PRP container. The platelet rich plasma may be collected in a plurality of cycles. Between collection cycles, the method may transfer a portion of the volume of anticoagulant from the red blood cell container to the PRP container.

Oxalate decarboxylase crystals, including stabilized crystals, such as cross-linked crystals of oxalate decarboxylase, are disclosed. Methods to treat a disorder associated with elevated oxalate concentration using oxalate decarboxylase crystals are also disclosed. Additionally disclosed are methods of producing protein crystals.

This invention relates to dialysis systems and methods. In some implementations, a method includes applying vacuum pressure to a device of a dialysis system, and then determining, based on a detected fluid level or measured pressure, whether the device is functioning properly.

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

A functional medical package is disclosed having a disposable package and a sterile container removably received inside the disposable package. A subsystem is received in the sterile container and is configured to be at least partially inserted into a host. The sterile container has an insertion exit opening for the subsystem and a liner closes the insertion exit opening. The liner is attached to the disposable package and automatically peels off the insertion exit opening when the sterile container is removed from the disposable package. Also disclosed are a method of manufacturing the medical package and a method of using the medical package with an inserter.

Examples of a module for housing unrelated electronic and electromechanical equipment for use during surgery. The module can include a lower section and a tower-like upper section. The lower section can house unrelated electronic and electromechanical equipment. The tower-like upper section can be located on top of the lower section. A water-resistant cowling can enclose at least a portion of the lower section and the tower-like upper section. A cartridge containing one or more ultraviolet-C producing lights can be protectively housed within the tower-like upper section. The cartridge containing one or more ultraviolet-C producing lights can be configured to emerge upward from a top of the tower-like upper section to substantially seat itself on the top of the tower-like upper section when activated allowing the ultraviolet-C light to disinfect the patient and staff-contacting upper surfaces of the equipment in the operating room.

Provided herein are materials and methods of reducing contamination in a biological substance or treating contamination in a subject by one or more toxins comprising contacting the biological substance with an effective amount of a sorbent capable of sorbing the toxin, wherein the sorbent comprises a plurality of pores ranging from 50 Å to 40,000 Å with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and sorbing the toxin. Also provided are kits to reduce contamination by one or more toxins in a biological substance comprising a sorbent capable of sorbing a toxin, wherein the sorbent comprises a plurality of pores ranging from 50 Å to 40,000 Å with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and a vessel to store said sorbent when not in use together with packaging for same.