A powder aerosolization apparatus comprises a housing comprising an outlet adapted to be inserted into a user's mouth and one or more bypass air openings. A receptacle support within the housing supports a receptacle containing a powder pharmaceutical formulation. A puncturing mechanism within the housing creates in the receptacle one or more inlet openings and one or more powder outflow openings, wherein the powder outflow openings have a total area of from 0.2 mm.sup.2 to 4.0 mm.sup.2. Upon a user's inhalation through the outlet, air flows through the one or more bypass air openings and through the receptacle to aerosolize the powder pharmaceutical formulation in the receptacle. In one version, the relative flow parameters between the flow through the one or more bypass openings and the one or more powder outflow openings are selected so that flow of aerosolized pharmaceutical formulation does not occur until a predetermined inhalation flow rate is achieved.

A nasal composition is provided comprising or consisting of a first composition part in the form of a liquid for nasal application to a patient in use, and a second composition part in the form of a powder for nasal application to the patient in use. The first and second composition parts are applied to the patient separately or together as required.

A nasal delivery device for and a method of delivering substance to a nasal airway of a subject, the nasal delivery device comprising: a mouthpiece (519) through which the subject in use exhales to cause closure of the oropharyngeal velum of the subject; a nosepiece (517) for fitting to a nostril of a subject, the nosepiece including a nozzle (549) through which substance is in use delivered to the nasal airway; and a manually-actuatable substance supply unit (520) for delivering substance through the nozzle of the nosepiece.

A method for treating migraines is disclosed. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent, including small molecules and peptides being administered to a patient in need of treatment. In particular, the drug delivery system is designed for inhalation for delivery of drugs to the pulmonary circulation in a rapid and therapeutically effective manner.

Dispensing apparatus is provided for delivering and/or dispensing a pre-determined amount of a product in use. The apparatus includes dispensing means having inlet means for allowing product to enter the dispensing means in use, outlet means for allowing product containable within the dispensing means in use to be dispensed therefrom during a dispensing action of the apparatus, and channel means provided between the inlet means and the outlet means for allowing product to move between the inlet means and the outlet means in use. Recess means are defined in the channel means. The dimensions of the recess means define or substantially define the pie-determined amount of product that can be delivered through the outlet means for each dispensing action of the apparatus. The inlet means and/or at least one aperture defined in the dispensing means is arranged and/or is of such dimensions that excess product contained in the channel means that cannot fit into the recess means is able to pass through said inlet means and/or said at least one aperture and out of the channel means in use prior to a dispensing action of product from the outlet means.

A nasal fluid dispenser device comprising: a body (10) comprising a hollow sleeve (11) and a top surface (15); and an actuator member (40) that is mounted to slide in said body (10) so as to actuate the device; the device further comprising two nasal extensions (20, 30), at least one of which forms a dispenser head provided with a respective dispenser orifice (21, 31), said nasal extensions extending from said top surface (15), each dispenser head being connected, during actuation, to a respective reservoir (50) that is arranged in said body (10), said two nasal extensions (20, 30) forming an angle lying in the range 30° to 60° relative to a longitudinal central axis (A) of said body (10).

Provided is a Dry Powder Inhaler (DPI) arrangement comprising a DPI arranged in fluid communication with a spacer device (110) comprising a bag (112) and a body (118) including inlet (114) and opposed outlet (116), the inlet (114) and opposed outlet (116) being provided on, and integral with, the body (118). The body (118) and bag (112) combine to form chamber (120) for operatively receiving vaporised dry powder medication. The inlet (114) and outlet (116) each are in the form of a port that is in fluid flow communication with the chamber (120). The inlet (114) and outlet (116) define, and are separated by, a broad V-formation formed as part of the body (118). The body (118) further includes an elliptical lower perimeter (118.1) defining flange (118.2), for demountably receiving bag (112).

A method of manufacturing a flowable and dispersible powder includes solubilizing a lipophilic substance in a terpene to form a mixture and treating the mixture to form a nanoemulsion dispersed in an aqueous solution. The aqueous solution includes at least one functional excipient. The nanoemulsion is then spray dried, thereby evaporating first the aqueous portion and then the terpene to form a dry powder formed from solid particles comprising the lipophilic substance.

A dry powder delivery device may be configured to provide micronized dry powder particles to airways of a user. The device may include a cylindrical container delimiting a chamber containing at least one magnetically-responsive object, a motor external to said chamber, a magnet external to the chamber and rotatably coupled with the motor, and an outflow member configured to direct airflow to a user. The magnetically-responsive object may be coated with micronized dry powder particles, and the motor may be operable to rotate the magnet about an axis. Rotation of the magnet creates a magnetic field that causes the magnetically-responsive object to move in response to the magnetic field and collide with a side wall of the container to deaggregate the dry powder particles and aerosolize the dry powder in the chamber.

A medication dispenser includes a casing, a notched wheel and a circuitry unit. The casing includes a mouthpiece. The notched wheel has a plurality of notches, and is rotatable to register the notches with the mouthpiece. The circuitry unit includes an annular magnetic member co-rotatably mounted to the notched wheel, and a Hall sensor. The magnetic member has a plurality of alternately arranged first and second magnetic poles. The Hall sensor is in a first detecting state when it detects one of the first magnetic poles, and is in a second detecting state when it detects one of the second magnetic poles.