A medicament for inhalation is provided. The medicament comprises at least a first layer comprising a first active pharmaceutical ingredient in powder form and at least a second layer comprising at least a second active pharmaceutical ingredient in powder form. The second layer is disposed on the first layer. A container for dispensing a medicament and methods of making are also described.

A medicament for inhalation is provided. The medicament comprises at least a first layer comprising a first active pharmaceutical ingredient in powder form and at least a second layer comprising at least a second active pharmaceutical ingredient in powder form. The second layer is disposed on the first layer. A container for dispensing a medicament and methods of making are also described.

A face engaging device such as a nozzle, facemask, etc., may include a housing including a fluid channel extending through the housing to an opening configured to be placed in fluid communication with the mouth of a user. The housing may include a first surface configured to be placed in contact with the skin of the user and a second surface exposed to the fluid channel. The face engaging device may also include a thermal actuator supported by the housing and including a first heat transfer surface position on the first surface, where the first heat transfer surface is configured to apply a thermal profile to the skin of the user when the opening is placed in fluid communication with the mouth of the user.

A face engaging device such as a nozzle, facemask, etc., may include a housing including a fluid channel extending through the housing to an opening configured to be placed in fluid communication with the mouth of a user. The housing may include a first surface configured to be placed in contact with the skin of the user and a second surface exposed to the fluid channel. The face engaging device may also include a thermal actuator supported by the housing and including a first heat transfer surface position on the first surface, where the first heat transfer surface is configured to apply a thermal profile to the skin of the user when the opening is placed in fluid communication with the mouth of the user.

A nozzled cartridge (20) for storing medicine, according to an aspect of the present application, includes a medicine container (21) that is to be filled with a predetermined quantity of a powdered medicine, a nozzle portion (22) that is formed on the medicine container (21) and that ejects the powdered medicine, a closing member (24) that closes an opening (22a) in the nozzle portion (22), and a valve member (25) that functions as a plug to close another opening (23a) in the medicine container (21), and that is opened when administering medicine. The nozzled cartridge (20) is detachably mountable to a sprayer (30) when administering medicine.

The accessory (110) for an inhaler (100) is adapted to be removably assembled on a casing (101) of the inhaler (100), and comprises: an acceleration sensor (112), an optical type proximity sensor (113), an electronic circuitry (114) electrically connected to the acceleration sensor (112) and to the proximity sensor (113); the electronic circuitry (114) in combination with the acceleration sensor (112) and the proximity sensor (113) is adapted to detect a drug administration process; the electronic circuitry (114) in combination with the acceleration sensor (112) is adapted to detect an inhalation flow inside said inhaler (100).

In various aspects, the present disclosure pertains to methods of treating or preventing bleeding at a tissue site comprising applying a chitosan powder composition to the tissue site. In various aspects, the present disclosure pertains to chitosan powder compositions for application to a tissue site, where the powder compositions comprise a chitosan salt, a crosslinked chitosan, a derivatized chitosan, or a combination thereof. In various aspects, the disclosure pertains to catheter assemblies, which are preloaded with a chitosan powder composition and which are configured to deliver the chitosan powder composition a tissue site.

A powder inhaler assembly includes a powder inhaler including a metering device having a dosing recess and movable, with respect to a container and to an inhalation channel, between an idle state, in which the dosing recess is in communication with an opening of the container so as to be filled with a dose of the powdered medicament, and a triggered state, in which the dosing recess is in communication with the inhalation channel for enabling inhalation of a dose of the powdered medicament contained in the dosing recess through a mouthpiece. An electronic module is attachable to the powder inhaler and includes a non-contact sensor positioned and configured to sense position(s) of at least part of the metering device to detect at least when the metering device is in the triggered state.

An inhaler for administering powdery dry substances comprises two substance carrying disks (2, 3). Each disk has a cavity filled with a powdery dry substance. The substance carrying disks (2, 3) are rotatably arranged about a common axis of rotation such that the cavities are opposite each other. The inhaler further has an airway (4) having a piercing nozzle (41). The piercing nozzle is disposed between the substance carrying disks (2, 3).

A medical agent inhaler includes a body that is provided therein with a container accommodating chamber, a tubular mouthpiece that protrudes upward from the body, an inhalation passage having a first end that is open to a container accommodating part and a second end that is open to an upper end of the mouthpiece, a container that is accommodated in the container accommodating part and is provided therein with a medical agent accommodating chamber of which an upper side is formed as an opening, the container being capable of switching positions between a dosing position where the opening of the medical agent accommodating chamber is communicated with the inhalation passage and a storage position where the opening is separated from the inhalation passage, and an inflow passage that is disposed on the body to be positioned closer to the upper side than the container accommodating part.