Summary

The invention relates to powdered pharmaceutical formulations which, in addition to carrier particles and particulate active ingredient which preferably adheres to the surface of the carrier particles, contains a mixing element, wherein the formulation fluidized in the carrier gas stream can contain the mixing element. Preferably, the powdered pharmaceutical formulation is packaged as a single dose, for example filled into a container as a single dose, for example in a capsule. The mixing element has a size of at least 1 mm to 10 mm in a first dimension and a size of at least 50% of the size it has in the first dimension in the other two dimensions.

A dry powder aerosol delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The dry powder aerosol delivery device includes a housing, a cartridge, and a dry powder dispersion mechanism, and at least one differential pressure sensor. The dry powder delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The dry powder aerosol delivery device is then actuated to generate a plume of particles having an average ejected particle diameter within the respirable size range, e.g., less than about 5-6 μm, so as to target the pulmonary system of the user.

A method for fabricating an inhalation device includes the steps of disposing a medicament carrier with a first member, the carrier being connected with a layer; engaging a second member with the first member to support the layer therebetween, the second member including a cutting surface and defining a cavity; and translating the carrier relative to the members to dispose the carrier with the cavity and cut the layer about the carrier. In some embodiments, manufacturing systems, manufacturing apparatus, inhalation devices, dispensing devices, and medicaments are disclosed.

A dry powder inhaler is disclosed. The dry powder inhaler includes a first housing member and a second housing member being rotatable in relation to one another to prepare administering a medicament dose from at least one medicament reservoir. An air inlet, a first air outlet, and a second air outlet are provided. The air inlet and the first air outlet are connected by a first air channel via a dosage mechanism configured to arrange a dose from the reservoir into the first air channel. The air inlet and the second air outlet are connected by a second air channel. An inhalation chimney is provided internally forming the proximal portion of the first air channel and comprising the first air outlet at a first end thereof.

A system for delivering an agent including a plurality of particles to a target site. The system incudes a catheter having a first wall defining an inner lumen for delivery of the agent to the target site, and a second wall surrounding the first wall to define an outer lumen therebetween for delivery of a fluid to the target site. The catheter has a distal end terminating with a primary opening of the inner lumen and a secondary opening of the outer lumen. A hub associated with a proximal end of the catheter includes a first inlet for receiving a supply of the agent and a second inlet for receiving a supply of the fluid, wherein the first inlet is in fluid communication with the inner lumen, and the second inlet is in fluid communication with the outer lumen.

A dry powder inhaler and an adherence and/or compliance monitor for use with the inhaler are provided. The inhaler has a cover which is pivotable relative to its housing in order to expose a mouthpiece. The monitor has one or more sensors. The inhaler and the monitor have formations for mounting the monitor onto the inhaler. The inhaler and monitor are designed so that when the monitor is mounted onto the housing of the inhaler and the cover is opened, the cover at least partially covers and protects the monitor.

A dry powder inhaler and an adherence and/or compliance monitor for use with the inhaler are provided. The inhaler has a cover which is pivotable relative to its housing in order to expose a mouthpiece. The monitor has one or more sensors. The inhaler and the monitor have formations for mounting the monitor onto the inhaler. The inhaler and monitor are designed so that when the monitor is mounted onto the housing of the inhaler and the cover is opened, the cover at least partially covers and protects the monitor.

A dry powder inhaler is provided. The inhaler is adapted for detachably mounting a compliance monitor having a pressure sensor. The inhaler has a housing comprising first and second shell parts, and a mouthpiece which defines an inhalation passage. An external surface of the housing has an orifice. A conduit from the orifice to the inhalation passage is formed by a channel in one of the shell parts and a corresponding channel cover in the other shell part. When the compliance monitor is mounted on the housing, the pressure sensor is adjacent to the orifice and is in fluid communication with the inhalation passage via the conduit.

A dry powder inhaler is provided. The inhaler is adapted for detachably mounting a compliance monitor having a pressure sensor. The inhaler has a housing comprising first and second shell parts, and a mouthpiece which defines an inhalation passage. An external surface of the housing has an orifice. A conduit from the orifice to the inhalation passage is formed by a channel in one of the shell parts and a corresponding channel cover in the other shell part. When the compliance monitor is mounted on the housing, the pressure sensor is adjacent to the orifice and is in fluid communication with the inhalation passage via the conduit.

Provided herein are dry powder formulations comprising epinephrine alone or in combination with at least one enabling agent suitable for nasal application. Also provided are unit dose forms and devices comprising such formulations and methods of using such formulations for the treatment of various conditions including anaphylaxis, anaphylactoid reaction, respiratory conditions, hemodynamic collapse, and for administration during cardiopulmonary arrest and other life-threatening conditions.