A system for respiration-controlled application of aerosol in powder form during artificial respiration or assisted respiration of a patient including an interface contacting the patient's respiratory tract, a unit for generating a respiratory gas flow, at least one inspiration line through gas flow is conducted to the interface, an aerosol generator, at least one aerosol line through which the generated aerosol is conducted from the aerosol generator to the interface, and a respiration sensor that detects the patient's respiration signal. A valve in the at least one aerosol line is controlled based on the detected respiratory signal. An intermediate store for generated aerosol in powder form is arranged between the valve and the aerosol generator. The gas flow has a first pressure that is higher than or equal to ambient pressure and the aerosol has a second pressure that is higher than or equal to the first pressure.

Provided is a blister pack for a dry powder inhaler, which dry powder inhaler is configured to deliver a first powder medicament and a second powder medicament different from the first powder medicament. The first and second powder medicaments are contained within blister pockets defined in a strip. A series of blister pockets is defined in the strip, which series extends linearly along the length of the strip. The first and second powder medicaments are contained in blister pockets, e.g. respective blister pockets, of the series. Alternatively or additionally, each of the blister pockets is elongated such as to have a largest dimension parallel with the length of the strip. These measures, either individually or in combination, enable minimizing of the width of the strip in spite of the strip accommodating both the first and second powder medicaments. This, in turn, may enable the depth/thickness of the dry powder inhaler to be minimized, and/or additional space to be provided inside the dry powder inhaler for accommodating, for example, use detection and wireless connectivity electronics for sending use detection data to an external device, such as a smartphone.

Disclosed are dry powder inhalers for delivering medicament to a user from a blister pack, the blister pack having a plurality of spaced-apart blister pockets containing doses of the medicament. The inhalers comprise: a housing for accommodating unused and used portions of the blister pack together with a dispensing mechanism for selectively opening the blister pockets; and a manifold component through which air can be drawn in use of the inhaler. The manifold component comprises: a primary air inlet opening for receiving first external air; an air outlet opening for providing the external air from the primary air inlet opening into an opened blister pocket, the primary air inlet opening being fluidly connected to the air outlet opening by a primary air delivery conduit formed in the manifold component; a medicament inlet opening for receiving air-entrained medicament from the opened blister pocket, the air outlet opening and the medicament inlet opening being arranged side-by-side to enable simultaneous communication with the opened blister pocket; and a medicament outlet opening for delivery of the air-entrained medicament from the opened blister pocket to the user, the medicament inlet opening being fluidly connected to the medicament outlet opening by a medicament delivery conduit formed in the manifold component. The disclosed inhalers embodiments provide a variety of improvements to the design of the manifold component.

Disclosed is a dry powder inhaler for delivering medicament from at least one blister pack, each blister pack having a plurality of spaced-apart blister pockets containing doses of the medicament. The inhaler comprises: a housing for accommodating unused and used portions of the at least one blister pack together with a dispensing mechanism for simultaneously opening at least two blister pockets at a time; and a manifold component through which air can be drawn in use of the inhaler. The manifold component comprises: first and second air inlet openings for receiving external air a first air outlet opening for providing the external air to a first opened blister pocket and a first medicament inlet opening for receiving air-entrained medicament from the first opened blister pocket, the first air outlet opening and the first medicament inlet opening being arranged side-by-side to enable simultaneous communication with the first opened blister pocket; a second air outlet opening for providing the external air to a second opened blister pocket and a second medicament inlet opening for receiving air-entrained medicament from the second opened blister pocket, the second air outlet opening and the second medicament inlet opening being arranged side-by-side to enable simultaneous communication with the second opened blister pocket; and a medicament outlet opening for delivery of the air-entrained medicament from the first and second opened blister pockets to the user, the first and second medicament inlet openings being fluidly connected to the medicament outlet opening by a medicament delivery conduit formed in the manifold component. The first and second air inlet openings are fluidly connected to the first and second air outlet openings by respective first and second air conduits in the manifold component, wherein the air conduits are separately provided so that the external air from each of the first and second air inlet openings does not mix with the external air from the other of the first and second air inlet openings before reaching the first and second opened blister pockets.

A method for treating patients with COVID-19 and/or other respiratory conditions includes administering eighty-five milligrams of dapsone twice daily for twenty-one days. A variety of dapsone formulations and delivery devices are disclosed, including an inhaler, nasal spray, nasal gel, otic formulation, intravenous formulation, oral solution, oral suspension, patch and suppository.

An aerosolization apparatus comprises a housing defining a chamber having one or more air inlets. The chamber is sized to receive a capsule which contains an aerosolizable pharmaceutical formulation. The aerosolization apparatus further comprises a puncturing mechanism within the housing. The puncturing mechanism comprises an alignment guide and a puncture member, wherein the alignment guide comprises a surface adapted to contact the capsule while the puncture member is advanced into the capsule to create an opening in the capsule. At least a portion of the surface is sloped relative to the longitudinal axis of the capsule. Alternatively or additionally, the surface may comprise one or more protrusions. An end section is associated with the housing. The end section is sized and shaped to be received in a user's mouth or nose so that the user may inhale through the end section to inhale aerosolized pharmaceutical formulation that has exited the capsule through the opening created in the capsule. The alignment guide allows for more consistent puncturing of the capsule and a longer lifetime of the apparatus.

A medicine powder delivery device and a medicine bottle thereof and a bottle cap of the medicine bottle are disclosed. The medicine powder delivery device includes a medicine bottle and a gas supply member. The medicine bottle has a bottle body and a bottle cap. The bottle body is filled with a medicine powder. When the bottle body is inverted, the bottle body has an unfilled space that is not filled with the medicine powder. The bottle cap includes a cap body, a medicine delivery tube, and a gas delivery tube. The cap body covers the bottle body. The medicine delivery tube and the gas delivery tube extends into the cap body. The medicine delivery tube communicating with the bottle body the gas delivery tube inserted into the unfilled space of the bottle body. The gas supply member is connected to the gas delivery tube.

A holder for an inhaler article that includes a sleeve positioned within a housing cavity, a piercing element, and a lockout mechanism. The sleeve comprises a sleeve cavity arranged to receive the inhaler article. The sleeve is movable within the housing cavity between a first and second position. The piercing element is arranged to pierce the inhaler article received within the sleeve when the sleeve is moved from the first position to the second position. The lockout mechanism comprises a guide, a follower member coupled to the sleeve, and a retaining section. The follower member is arranged to move along the guide into the retaining section as the sleeve moves from the second position and back to the first position. The retaining section is arranged to hold the follower member when the sleeve has returned back to the first position, thus retaining the sleeve in the first position.

A dispenser for powdery substances contained in a separate package that has a container part with removable container cover, wherein an aspirated air flow is further sucked predominantly through the container part after removal of the container cover from the container part, such that two air flows entering through slits in a lid that can be pivoted around a pivoting axis evacuate the container part from its two ends, and after merging enter a vortex chamber upstream from a mouthpiece. Outside air inlet openings for a third air flow are formed in a housing part covered by the lid in a radial extension to the pivoting axis.

An inhaler article includes a body extending along a longitudinal axis from a mouthpiece end to a distal end. A capsule cavity may be within the body bounded downstream by a mouthpiece. An air inlet at the distal end and an air outlet at the mouthpiece end. A first mouthpiece air channel may extend from the distal air inlet, through the capsule cavity to the mouthpiece air outlet. A second mouthpiece air channel may extend from a point downstream of the separator to the mouthpiece air outlet. The second mouthpiece air channel may be separate from the first mouthpiece air channel. A coating layer of flavour may be disposed on a surface of the second mouthpiece air channel and a protective layer may be disposed on the coating layer of flavour.