An applicator syringe (1) is disclosed containing a sterile solution having a medical active substance, in particular for introducing the solution containing the active substance via a urinary tract and/or bladder catheter into the bladder of a patient. The applicator syringe (1) includes a cylindrical jacket (2), which is closed by a syringe cover (3), which is integrally formed with the jacket (2) and includes an outlet opening (5) and is formed from a cycloolefin copolymer (COC). The applicator syringe (1) furthermore comprises a plunger tip made of an isobutene-isoprene rubber, which is halogenated in particular. The sterile solution containing the medical active substance is arranged in a cavity (6) delimited by the cylindrical jacket (2) having syringe cover (3) and the plunger tip.

A system and method for increasing the speed of blood and wall shear stress (WSS) in a peripheral vein for a sufficient period of time to result in a persistent increase in the overall diameter and lumen diameter of the vein is provided. The method includes pumping blood at a desired rate and pulsatility. The pumping is monitored and adjusted, as necessary, to maintain the desired blood speed, WSS and pulsatility in the peripheral vein in order to optimize the rate and extent of dilation of the peripheral vein.

A flexible, polymer sleeve is provided that is everted into a body passageway in such a manner as to exert minimal rubbing friction on the internal walls of such passageway. The sleeve is housed within a tube assembly comprising a posterior tube that telescopingly slides into an insertion tube. The sleeve everts over the insertion tube, upon forward pressure applied thereon, as it extends forward into a body passageway, and consequently, causes the posterior tube to retract into the insertion tube. Multiple tubes can be telescoped to support the polymer sleeve and to keep a passageway open for the expelling of urine or body fluids, the insertion of tools, sanitation/antibacterial substances, or for the flow of liquids through the sleeve. The insertion tube can be locked in reference to the sleeve to prevent unintended removal of catheter assembly. Sleeve and tubing are removed by reversing the insertion and eversion movements.

A personal vapor inhaling unit is disclosed. An electronic flameless vapor inhaler unit that may simulate a cigarette has a cavity that receives a cartridge in the distal end of the inhaler unit. The cartridge brings a substance to be vaporized in contact with a wick. When the unit is activated, and the user provides suction, the substance to be vaporized is drawn out of the cartridge, through the wick, and is atomized by the wick into a cavity containing a heating element. The heating element vaporizes the atomized substance. The vapors then continue to be pulled by the user through a mouthpiece and mouthpiece cover where they may be inhaled.

The present invention provides systems, methods, and articles for stress reduction and sleep promotion. A stress reduction and sleep promotion system includes at least one remote device, at least one body sensor, and at least one remote server. In other embodiments, the stress reduction and sleep promotion system includes machine learning.

A fluid management system for the treatment of ascites, pleural effusion or pericardial effusion is provided including an implantable device including a positive displacement gear pump coupled to an inflow catheter and an outflow catheter, a battery, a processor, and at least one sensor configured to detect a presence of an infection marker, and an external charging and communication system configured to wirelessly communicate transcutaneously with the implantable device. The processor is programmed to periodically activate the pump to move fluid from a first cavity to a second cavity, e.g., the patient's bladder, via the inflow and outflow catheters; receive a signal indicative of the presence of the infection marker from the at least one sensor; generate an alert upon receipt of the signal; and communicate the alert to the external charging and communication system to notify the user.

The invention relates to a non-heated humidification device comprising a wick; a chamber for holding water in contact with the wick; and a gas inlet to the chamber, wherein the chamber and wick are configured to humidify gas passing through or over the wick at ambient conditions. The device may be modular and attachable to a flow generator. The device may comprise dual gas circuits and a control system for controlling the gas flow through the gas circuits in order to control the humidity of the gas output.

The present disclosure is directed to multi-dose containers, such as eye drop bottles, nasal spray bottles, cosmetic and fragrance containers, and the like, in which at least a portion of an interior wall of the container, which is in contact with a fluid product, is provided with an anti-microbial coating. The anti-microbial coating is effective to inhibit the growth of microbes and/or inactivate or kill microbes, such as bacteria, that may be introduced into the lumen during use of the product. As such, the shelf life of the product after first use may be increased and/or the amount of preservatives or excipients in the fluid product may be decreased. The containers may also include one or more oxygen barrier coatings, which may increase the shelf life of the product prior to first use.

Methods and apparatuses for non-invasive auricular and/or cervical stimulation to modulate multiple integrated neural networks. For example described herein are methods and apparatuses (e.g., devices, systems, etc.) for modulating nerves located at the base of the skull or in the neck, such as craniocervical nerves, cranial nerves, or cervical spinal nerves and/or the auricular nerve for influencing one or more biological homeostasis and related physiological processes.

A system for applying a lavage fluid to a surface, the system having a body configured to house a lavage fluid, an application member in fluid communication with the body, the application member being configured to dispense the lavage fluid, and a warming component configured to communicate with the body so as to transfer energy from the warming component to the body sufficient to warm the lavage fluid housed in the body.