A medical guide wire with excellent visibility is provided. A medical guide wire including: a wire body (2) that is flexible and long; a covering layer (3) covering a surface of the wire body (2); and a wire material (4) helically arranged on the covering layer (3), wherein the covering layer (3) is formed of a transparent material same as a transparent material of the wire material (4), and the wire material (4) is arranged at a regular pitch along the longitudinal direction of the wire body (2).

The present invention relates to a prefilled plastic container, such as a plastic syringe, comprising an aqueous botulinum toxin formulation. The aqueous botulinum toxin formulation in the prefilled plastic container is stable for a prolonged time period. Furthermore, the present invention relates to a kit comprising the prefilled plastic container, and to the use of the prefilled plastic container for therapeutic and cosmetic purposes.

The invention relates to a wetting mechanism 20 for wetting a tube 12 of a catheter 10. The wetting mechanism 20 includes a housing 16 positioned initially at or proximal to the tip end 13 of the catheter tube 12. The housing 16 comprises a wetting chamber 23 into which at least a portion of the catheter tube 12 is able to be introduced and be moved therethrough to wet the catheter tube 12 in use. The wetting mechanism 20 includes a stopper 26 which is moveable between a first and second positions to prevent or allow the tip end 13 of the catheter tube 12 to be moved through the wetting chamber 23.

A patient interface is disclosed which is comfortable for the user to wear and includes at least in part a moisture permeable or breathable area in the body of the patient interface. In another embodiment the patient interface is a strapless mask that is moulded to fit the contours of a user's face and maximise the mask-to-skin seal. An adhesive material is bonded to the mask cushion and is stamped in place to form substantially the same shape as the cushion such that it fits the facial contours of the user.

The invention relates to a lubricant coating (5) for a medical injection device (1), comprising successively: —a bottom layer (50) in contact with the medical device surface (21) of the container to be lubricated, comprising a mixture of cross-linked and non-cross-linked poly-(dimethylsiloxane), —an intermediate layer (51) consisting essentially of oxidized poly-(dimethylsiloxane) and having a thickness comprised between 10 and 30 nm and, —a top layer (52) consisting essentially of non-cross-linked poly-(dimethylsiloxane) and having a thickness of at most 2 nm. The invention also relates to a medical injection device comprising such a lubricant coating, and a manufacturing process for said coating.

A drug delivery device includes a housing defining a shell having a proximal end and a distal end and a longitudinal axis extending between the proximal end and the distal end, a needle assembly at least partially disposed within the housing at the proximal end, a drive assembly at least partially disposed within the housing and operably coupled to the needle assembly, and an audible indicator operably coupled to the drive assembly. The needle assembly includes a syringe containing a medicament and a needle or a cannula. The drive assembly is movable between an initial position and a second position that results in the medicament being expelled from the syringe. Upon the drive assembly being positioned in the second position, the audible indicator engages the drive assembly to generate an audible sound indicating the medicament has been expelled from the syringe.

Described herein are implantable ports including a housing with a fluid receptacle, a port stem in fluid communication with the fluid receptacle, and a septum covering the fluid receptacle. The ports may be configured to reduce the priming volume by including a plurality of fluid-locked chambers and/or one or more base mats. The ports may also include a hydrophobic coating on one or more surfaces thereof.

In some examples, an aspiration system a catheter and a fluid flow sensor. The fluid flow sensor includes a fluid inlet, a fluid outlet, and a flow oscillator. The fluid inlet is configured to receive fluid from the catheter. The flow oscillator configured to oscillate flow of the fluid through the fluid flow sensor to generate flow-induced vibrations. The fluid outlet is configured to discharge the fluid.

Apparatus and methods are provided for delivering fluids into a patient's body that includes a tubular member including a proximal end, a distal end sized for introduction into a patient's body, and a fluid delivery lumen extending between the proximal and distal ends; and a flexible pad on the distal end including a tissue contacting surface, a passage communicating with the fluid delivery lumen, and plurality of capillary channels in the tissue contact surface communicating with the passage, the capillary channels configured to deliver fluid from the fluid delivery lumen and passage to tissue contacted by the tissue contact surface.

An assembly method of an apparatus suitable for pressurized liquid transfusion is disclosed. In one step, a nozzle is to be inserted into the through hole of an elastomeric ring. Because the dimension of the nozzle is larger than the through hole, the internal wall of the elastomeric ring is tensioned and deformed so as to fit the nozzle. In one step, the elastomeric ring along with the nozzle is inserted into a receptacle. The dimension of the outer contour of the elastomeric ring needs to be decreased so as to be accommodated by the receptacle. Due to the flexibility of the elastomeric ring, it resumes at least partially to its original shape. Therefore, proper seal is created and maintained between the elastomeric ring and the nozzle such that leakage and pressure loss may be prevented. The foregoing is capable of working under high-pressured environment for prolonged use.