A seal for a ventilator piston. The seal is configured to be secured to a ventilator piston and received within a piston chamber of a ventilator to provide a slidable seal against an inner wall of the piston chamber. The seal comprises a deformable body comprising a first material, and a layer of a friction-reducing material provided on at least a portion of the deformable body and configured to provide slidable sealing contact with the inner wall of the piston chamber. The first material and the friction-reducing are different. Also provided is a ventilator comprising such a seal, and a method of manufacturing such a seal.

A vasculature navigation system may include a dilator having a proximal end and a distal end located opposite the proximal end, the dilator comprising a guidewire lumen extending between the proximal end and the distal end, the dilator defining a proximal portion and a distal portion located opposite the proximal portion. In some embodiments, the vasculature navigation system also includes an access port located at the proximal end of the dilator, a distal port located at the distal end of the dilator, and a hemostasis valve coupled to the proximal portion of the dilator. The hemostasis valve may be configured to control fluid flow between the proximal portion and the distal portion. In some embodiments, a flush port is coupled to the proximal portion of the dilator and located distal to the hemostasis valve, and the flush port is coupled to a fluid supply source.

A container assembly for containing and delivering a medicament is described. The container assembly includes a container having a first end and a second end. The first end includes an opening, and a plunger assembly at least partially disposed in the container. The plunger assembly includes a main body and at least one resilient portion at least partially retained by a groove in the main body. The resilient portion forms a seal with the container. The plunger assembly forms a temperature resilient seal with the container such that the container assembly is operable to contain a medicament between the seal and the opening at: (a) room temperature, and (b) during freeze storage of the medicament. The plunger assembly is moveable relative to the container at room temperature.

A patient interface is disclosed which is comfortable for the user to wear and includes at least in part a moisture permeable or breathable area in the body of the patient interface. In another embodiment the patient interface is a strapless mask that is moulded to fit the contours of a user's face and maximise the mask-to-skin seal. An adhesive material is bonded to the mask cushion and is stamped in place to form substantially the same shape as the cushion such that it fits the facial contours of the user.

The present invention relates a botulinum toxin prefilled syringe system with desirable injection force characteristics, in particular low gliding force and low break loose force, comprising a syringe barrel of glass containing a liquid botulinum toxin composition, a plunger stopper and a closure device such as a tip cap or a needle shield. In addition, the present invention relates to a kit comprising the botulinum toxin prefilled syringe system, and optionally instructions for use, and to the use of the botulinum toxin prefilled syringe system in therapeutic and cosmetic applications.

The present invention relates to an enema device (1;1′) comprising a delivery container (2) and an applicator nozzle (3), and wherein said delivery container (2) comprises two cavities (6,8;6′,8′), an outer cavity (6;6′) defined by an squeezable external body (7;7′), and an inner cavity (8;8′) defined by an inner flexible bladder (9;9′), and wherein one of said cavities (6;8′) is communicating with an outlet (10) for dispersing the enema though the applicator nozzle (3) and the other cavity (8;6′) is communicating with the surroundings via an air inlet (12). Thereby is provided a simple, inexpensive and essentially maintenance free enema device (1;1′) which can be used for self-administrating of an enema. The device (1;1′) will not only effectively prevent air from being mixed with the enema, but also ensure that the user easily can expel the enema, as the device (1;1′) will be perceived as full of enema at all times.

Aspects herein relate to a low-friction septum for providing a leak-resistant seal for use in a vascular access device. In an embodiment, a device for vascular access hemostasis is included having an enclosure defining a cavity and configured to at least partially receive a medical device. The device can include a first seal portion and a second seal portion, the cavity disposed between the first seal portion and the second seal portion. The device can include a barrel in structural communication with the second seal portion, the second seal portion including a septum seal. The second seal portion can define two or more discrete portions, each separated by one or more split lines. The discrete portions can include a mating surface to interface with mating surfaces of other discrete portions. The mating surface can include a surface topology including raised portions and depressions. Other embodiments are also included herein.

A fiber reinforced polyester polymer composition is disclosed that contains at least one tribological modifier. The tribological modifier may comprise an ultra-high molecular weight silicone alone or in combination with polyytetrafluoroethylene particles. The composition not only has excellent tensile properties but also can produce a low friction surface.

A holding device for holding packaging containers for pharmaceutical, medical, or cosmetic compositions includes: a plate-shaped carrier element which includes through-holes; receptacles including each a longitudinal direction, a first end, a second end, and a receptacle wall which partially encloses a receptacle interior and forms a wall body, the wall body: extending in the longitudinal direction through a respective one of the through-holes; and including a first opening at the first end, a second opening at the opposite second end, a first edge, and a second edge, the first opening being laterally directly surrounded by the at least one first edge, the second opening being laterally directly surrounded by the second edge, at least 50% of respective ones of the receptacles having a total height R.sub.t of a roughness profile of the first edge and/or the second edge which is not more than 0.50 mm.

An elongated medical instrument includes: a base material part; and an outer layer part made of a resin based on a resin suspension that is coated on an outer peripheral surface of the base material part; where a surface of the outer layer part has irregularly disposed recesses formed from cracks generated by drying of the resin suspension, and protrusions formed with an outer peripheral surface formed on an outer peripheral side of the recesses.