Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.

The present disclosure provides a method for the surface modification of microstructured components having a polar surface, in particular for high-pressure applications. According to the method, a microstructured component is contacted, in particular treated, with a modification reagent, wherein the surface properties of the component are modified by chemical and/or physical interaction of the component surface and of the modification reagent.

An inhalation spacer movable between a collapsed configuration and an expanded configuration. The spacer is made from paperboard having a bending stiffness of at least 2.5 mNm.

A liquid preparation for application to an inner side of a hollow body to produce a sliding layer on a packaging for pharmaceuticals or cosmetic products comprises the following constituents: a reactive silicone system for forming a silicone network of the sliding layer, a catalyst for catalyzing the cross-linking reaction of the reactive silicone system, at least one unreactive silicone oil, and at least one diluent. The diluent comprises a silicon-containing compound and a content of the at least one diluent in the preparation amounts to more than 45 percent by weight and less than 95 percent by weight in the preparation.

A bioelectronic device houses therapeutic cells and is configured to be implanted in a host. The device includes an electrochemical cell that produces oxygen gas from water when a voltage is applied. The oxygen gas produced by the electrochemical cell is stored in a gas diffusion chamber in the device. The therapeutic cells in a cell housing chamber in the device receive oxygen gas from the gas diffusion chamber to help keep the cells alive and functioning when the device is implanted in a low oxygen environment. The device receives power wirelessly.

An apparatus for pressurizing one or more airways of a user, including: a dental arch mold configured to receive a plurality of teeth, a port which may be at a front face of the dental arch mold, a first nasal pillow, a second nasal pillow, a multi-output air regulator, and a plurality of sensors. The multi-output air regulator and sensors allow the airway pressurization device to sense the pressures in as well as be in independent fluid communication with the port of the dental arch, the first nasal pillow, and the second nasal pillow, such that an equalization of pressures, or a determined pressure differential between each may be obtained.

The invention relates to a method for reducing an amount of sub visible particles in a pharmaceutical composition contained in a medical injection device comprising a container (1) including a barrel (10) lubricated with a lubricant coating (2) in contact with the pharmaceutical composition, and a stopper (14) in sliding engagement within the barrel (10), the container comprising a region (130, 121, 123) extending distally from the distal end (100) of the barrel which is not accessible to the stopper. During formation of said lubricant coating (2) on the inner wall of the barrel, the method comprises limiting lubricant from being deposited into said region (130, 121, 123) extending distally from the distal end (100) of the barrel.

Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface. In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent. In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent.

A respiratory mask includes a mask body having a face-engaging portion, and at least one retaining member connected to the mask body and including at least one engaging member for receiving and tethering a liner to the respiratory mask to generally overlie the face-engaging portion. The retaining member may include a flexible elongated body having a central portion and opposing ends, and a bottom surface arranged to be attached to the respiratory mask. The liner may include a liner body constructed from an absorbent material and having an outer edge, an inner edge, and an opening bounded by the inner edge, wherein an extending portion of the liner body is defined which extends outwardly beyond the face-engaging portion and includes at least one aperture for engaging the retaining member. A kit for use with a respiratory mask includes at least one liner and at least one retaining member.

A patient interface is disclosed that includes: a plenum chamber pressurisable to a therapeutic pressure; a seal-forming structure joined to the plenum chamber and comprising a nasal portion, an oral portion, and at least one hole configured to deliver a flow of air at said therapeutic pressure to at least the patients nares in use, the seal-forming structure constructed and arranged to maintain said therapeutic pressure in the plenum chamber throughout the patients respiratory cycle in use; a vent comprising a plurality of holes configured to allow a continuous vent flow from an interior of the plenum chamber to ambient; a positioning and stabilising structure comprising at least one tie and being configured to hold the seal-forming structure in a therapeutically effective position on the patient's head in use; and a textile portion configured to contact the patients face.