A heat exchanger for a blood circulation circuit comprises a hollow fiber membrane layer having a plurality of hollow fiber membranes, and a fixing portion fixing both end portions of the hollow fiber membranes from outsides of the hollow fiber membranes. The fixing portion mainly contains polyurethane, and each of the hollow fiber membranes has a heat conductive layer containing high density polyethylene, and an adhesion layer provided on an outside of the heat conductive layer, bonded to the fixing portion, and mainly containing a modified polyolefin resin.

Devices, systems, and methods are disclosed which permit ventilation therapy concurrent with humidity and aerosol drug delivery. Exemplary mixer-heaters employ alternating actuation of humidity and drug nebulizers and may use a single constant power setting for the heating section while keeping a controlled outlet temperature over the course of treatment.

A drug delivery device includes a drug product container, a pressurized vessel, and an urging member. The drug product container can have at least one flexible wall and defining a cavity configured to contain a drug product. The pressurized vessel can contain a gas under pressure. And the urging member is in working connection with the pressurized vessel such that, upon at least partial release of the gas under pressure, the urging member moves from a first portion of the drug product container to a second portion, thereby ejecting at least a portion of the drug product from the drug product container.

A patient interface a positioning and stabilising structure, which includes a gas delivery tube with a tube wall that has an interior passage for flow of pressurized air. A portion of the tube wall includes a patient contacting portion and a non-patient contacting portion. The patient contacting portion includes a layer of textile material or foam material configured to lie against the patient's head. At least a section of the non-patient contacting portion includes of a transparent and/or translucent material. The layer of textile material or foam material is bonded to the transparent and/or translucent material so that the tube wall is formed as a one piece construction. A plane extends generally transverse to longitudinal axis contains both (1) the textile material or foam material and (2) the transparent and/or translucent material, so that the patient may view the interior passage along a transverse axis extending through the plane.

Methods for performing endovascular procedures are described herein. The methods may comprise advancing an expandable member of a blood flow control device to a target location in a blood vessel of a patient, and rotating a circular gear positioned at least partially within a housing of a controller via the controller communicably coupled to the blood flow control device. Rotating the circular gear may translate a linear gear of a syringe pump fluidly coupled to the expandable member thereby adjusting a volume of the expandable member. Various blood flow control devices, control systems, and fluid delivery systems are also described herein. The fluid delivery systems may include a pump configured for manual or automated delivery of fluids, or configured to switch between automated and manual modes of delivery. The pump may be a syringe pump that utilizes a rack and pinion system, a motor, and a sensor to track the position and/or movement of a component of the syringe pump during fluid transfer. Alternatively, the pump may be a pressure differential pump that includes a flow restrictor and a pressure sensor that controls delivery of fluid from a fluid reservoir. Systems and methods including the syringe and pressure differential pumps are also described.

The present disclosure relates generally to the field of medical devices. In particular, the present disclosure relates to devices and methods to guide delivery devices and instruments. Exemplary instrument guides, including for endoscopes as delivery devices for cryogen delivery catheters and to guide cryogen decompression tubes as instruments, and methods for use of such instrument guides for use in body lumens at treatment sites, are disclosed.

A guide wire includes a core wire, a first resin layer that coats a part of the core wire, a coil body wound around another part of the core wire and an outer side of the first resin layer, and a second resin layer that coats the coil body, in which a part of the coil body is embedded in the first resin layer and the second resin layer.

A patient interface including a seal-forming structure with a textile membrane that has at least one hole such that the flow of air at a therapeutic pressure is delivered to at least an entrance to the patients nares and/or an entrance to the patients mouth. The seal-forming structure is constructed and arranged to maintain the therapeutic pressure in a cavity of a plenum chamber throughout the patients respiratory cycle, in use. The textile membrane includes a first portion that is held in a relaxed state and a second portion that is held in a taut state. The taut state of the second portion is configured to allow the seal-forming structure to include a three-dimensional shape that has multiple curvatures.

An improved guidewire may include an elongate shaft including a distal section and a proximal section extending proximally from the distal section. The elongate shaft includes a coiled portion disposed within the distal section. The coiled portion is curved in a first direction in a first plane. The elongate shaft includes a reverse curve portion curved in a second direction opposite the first direction. The reverse curve portion is disposed proximal of the coiled portion. A kit for forming the improved guidewire may include a guidewire having a coiled portion and a forming tool configured to form a reverse curve portion in the guidewire proximal of the coiled portion.

An integrated flow source is a limiting factor in numerous microfluidic applications. In addition to precise gradients and controlling molecular transports, a built-in source of stable and accurate flow can enable novel shear stress modulations for long-term cell culturing studies. The Tesla turbine, when used as a pump on the microfluidic regime, produces stable and accurate fluid gradients by utilizing laminar flow between its rotating discs Utilizing a stereolithography based 3D printer, a tesla pump (Ø10 cm) and associated housing capable of driving a microfluidic gradient is provided having a printed rotor surface topology of the pump in order to enhance pumping of biological fluids like blood at elevated viscosities. The surface topology is tuned via 3D pixilation, and this modulation completely recovered the pressure loss between pumping water at 1 cP versus glycerol solution at 3 cP. As a result, increased fluid viscosities, and even Non-Newtonian viscosities, can be used.