A device for creating intravascular access and guidewire placement includes a main body having a lumen and a piercing member disposed in the lumen. The piercing member moves distally out of the lumen and pierces tissue while moving. A needle guide is provided for guiding the piercing member, the needle guide having a distal end which comprises a first alignment member. A guidewire has a distal tip with a second alignment member disposed on the guidewire distal tip. The first alignment member may comprise a magnetic attachment, at least one magnetic implant, a proximity sensor, an ultrasonic sensor, or other suitable system for alignment of devices disposed on opposing sides of opaque tissue. Similarly, the second alignment member may comprise a magnetic attachment or implant, a proximity sensor, or an ultrasonic sensor.

Fluid reactors include a sealed housing enclosing a reactor core that includes at least one substrate-free multichannel reactor core element. Each reactor core element is made from a non-substrate mounted, open pore cellular network material having an asymmetric, tortuous, bi-continuous two-phase material structure and contains multiple perforating fluid channels. Multiple reactor core elements can be serially and/or parallelly piped in a sealed manner to form a reactor core for a fluid reactor with a higher production capacity.

Disclosed herein is a molecular imprinted protective face mask comprising a supportive structure, a surface material that receives and retains a molecular imprint and that is positioned to contact airborne molecules during use, a molecular imprint of a bioactive molecule wherein an imprinted cavity is at least one of a bioactive molecule with a molecular configuration that captures a specific airborne and/or microdroplet-borne molecule and a protein with a binding site that captures a specific molecule.

Drug delivery devices that have a flexible film, an array of nanoscopic, porous needles attached to a surface of the flexible film, and a therapeutic drug cargo loaded onto the needles. The drug delivery device may be applied to living tissue such that the surface of the flexible film contacts the living tissue and some or all of the needles are inserted into the tissue. The flexible film may then be dissolved while leaving the needles inserted in the tissue. The needles degrade in the living tissue over time causing release of the therapeutic drug cargo loaded onto the needles.

Microfluidic gas exchange devices may include one or more exchange modules (100), wherein each exchange module includes: a first layer comprising: one or more primary inlets (108); a first capillary network connected to the one or more primary inlets, wherein the first capillary network extends radially outward from at least one of the one or more primary inlets, and wherein the first capillary network includes one or more injection branches (104) and a series of microchannels (106); and one or more primary outlets connected to the first capillary network; and a second layer that includes a semipermeable membrane.

The design and structure of a fully automatic oxygen therapy apparatus is exhibited in this disclosure. The apparatus integrates a MEMS mass flow meter, an oximeter, a proportional valve and a smart liquid bottle. The control unit of the apparatus is embedded with a wireless communication device and powered by a battery pack. This apparatus is designed to replace the mechanical oxygen rotameter used in today's hospital or homecare oxygen therapy applications. With a set recipe or parameters locally or remotely, the disclosed apparatus can perform a fully automatic oxygen therapy for recovering the blood oxygen level of patient, without the frequent attention of the therapy administrator, and especially it significantly reduces the possibility of cross infection to the administrator during the attendance of the oxygen therapy process. The therapy process data are relayed to local users as well as a designated cloud or data center. This disclosure will be beneficial for both medical staffs and patient.

A microelectromechanical device utilizing one or more micropumps embedded in a mouthguard for treatment and detection of viruses in a person's mouth. The micropump pumps saliva through the device where it can, for example, be treated with heat to destroy viruses in the saliva. In another embodiment the device can be used to detect the presence of virus in the saliva utilizing DNA PCR or chronoamperometry.

A microfluidic device for increasing convective clearance of particles from a fluid is provided. A network of first channels can be separated from a network of second channels by a first membrane. The network of first channels can also be separated from a network of third channels by a second membrane. Fluid containing an analyte can be introduced in the network of first channels. Infusate can be introduced into the network of second channels, and waste-collecting fluid can be introduced into the network of third channels. A pressure gradient can be applied in a direction perpendicular to the direction of fluid flow in the network of first channels, such that the analyte is transported from the network of first channels into the network of third channels through the second membrane.

A pressure guidewire is provided that has a proximal end and a distal end. The pressure guidewire has a proximal section a sensor housing section, and an intermediate section. The proximal section extends from the proximal end of the pressure guidewire to a distal end of the proximal section. The sensor housing section is disposed adjacent to the distal end of the pressure guidewire. The intermediate section disposed between the proximal section and the sensor housing section. The intermediate section has a proximal end separate from the proximal section. The proximal end can be coupled to the distal end of the proximal section. The pressure guidewire has a tubular body positioned within the intermediate section. A pressure sensor is positioned in the sensor housing section

Provided is a smart inhaler and wearable smart mask configured to operate as an air ionizer and a controlled multi-liquid atomizer. The smart mask and smart inhaler use a mature technology to deliver various types of liquid solutions to different applications from health care, drug delivery, immunization to recreational and gaming uses. In addition, the smart mask contains multiple actuators to provide haptic feedback to the areas around the mask. The smart mask and inhaler have a direct communication path to a smart device or it can be a smart device by itself; its various environmental and gas sensors act as a feedback mechanism. The detection level of the organic and non-organic VOC gas emitted when exhaling can be communicated and stored for analysis purposes. The detected gas can be regenerated on the same smart mask or a different remote smart mask.