The present invention includes an apparatus for transdermal treatments comprising: an openable enclosure for a subject in communication with three or more sources of treatment modalities selected from: a source of ozone; a source of steam, a source of CO.sub.2/Carbonic Acid; a source of Far Infrared; and a source of pulsed electromagnetic fields (PEMF), wherein each of the three or more sources is in communication with an interior of the openable enclosure to treat the subject transdermally.

A system for stimulating phrenic nerves to provide smooth breathing patterns is provided. More specifically, by identifying contraction threshold voltages for muscles associated with each of the left and right portions of a patient's diaphragm, a phrenic nerve pacing signal customized for each phrenic nerve may be provided to a patient. More specifically, a voltage of a pacing voltage provided to a first phrenic nerve may be less than the contraction threshold while a voltage of a pacing voltage provided to a second phrenic nerve may be greater than the contraction threshold.

Provided is a neural probe array including a probe which is insertable into a nerve, the probe having a microchannel which induces the regeneration of the nerve, wherein an electrode is installed within the microchannel and is physically isolated from gliosis, and the microchannel is configured to receive a nerve growth factor for regenerating the nerve, and when the probe is inserted into the nerve, the electrode physically isolated from gliosis accomplishes neural signal acquisition and stimulation.

Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO.sub.2 gas analysis sensors without the use of a calibration gas.

Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.

Techniques are disclosed for treating arrhythmias using an implantable medical device. An implantable medical device that is adapted for implantation wholly within a heart chamber of the heart of a patient may include a reservoir containing one or more therapeutically useful doses of a drug for treating an arrhythmia. The implantable medical device may include processing circuitry configured to detect an occurrence of the arrhythmia in the heart of the patient. The implantable medical device may include a valve operable to be opened in response to detecting the occurrence of the arrhythmia in the heart of the patient to release a therapeutically useful dose of the drug into the heart of the patient to treat arrhythmia of the heart.

Noninvasive treatment (e.g., neuromodulation) can be achieved using vibrational energy applied via one or more wearable devices. A noninvasive treatment device includes a vibrational actuator disposed within a housing that can be secured to a user's body at or adjacent a treatment site. One or more sensors can collect physiological data before, during, or after application of vibrational energy to monitor a user's condition. Machine learning or other suitable approaches can be used to analyze sensor data to detect medical conditions and/or to effect treatment of medical conditions using devices as described herein.

An electrical stimulation apparatus includes: a cell cluster container comprising a cell cluster configured to secrete an active material; an indicator container comprising an indicator; a controller configured to apply a stimulation voltage to the cell cluster container based on a sensing signal received from the indicator container; a first entrance connected to the cell cluster container and configured to allow either one or both of the cell cluster to be retracted and a new cell cluster to be injected; and a second entrance connected to the indicator container and configured to allow either one or both of the indicator to be retracted and a new indicator to be injected.

A pessary system for providing pelvic floor support for USL and other ligaments. The pessary has an elongated probe with independently inflatable balloons each located substantially the same distance from the insertion end of the probe and which inflate into separate radial sectors. The probe can be inserted into a vaginal cavity and the balloons inflated provide mechanical support to the USLs. Independent inflation of each balloon allows the mechanical USL support provided to be varied on left and right sides to compensate for differences in the degree of degradation and positioning of the USL ligaments on either side.

An electrical stimulation apparatus provides an electrical stimulation signal as a DC pulse train at a frequency between 20 kHz and 50 kHz, with the electrical stimulation signal applied to the body of a patient at an injury site, based on sequentially activating respective subsets among a set of electrodes included in an electrode carrier that places the electrodes in contact with the body of the patient. An electrical stimulation method sequentially activates, via an electrical stimulation signal, respective subsets of electrodes among a set of electrodes contacting the body of a patient at an injury site on the body of the patient. Advantageously, in one or more embodiments, the sequential activation follows an activation sequence that “moves” the sources and sinks for the electrical stimulation signal around the injury site, thereby creating spatially distributed signal paths through or across the injury over time.