A holding device including a sleeve wall having an outer wall surface and an inner wall surface. The inner wall surface forms a capsule insertion channel extending through an entirety of the sleeve wall. A lip is at an end of the capsule insertion channel and extends toward a center of the capsule insertion channel. The inner wall surface has a recess at a first distance along the inner wall surface from the lip, a base extending outward from the outer wall surface of the sleeve wall; and a flexible retaining element in the recess. The recess being configured to prevent movement of the flexible retaining element along the inner wall. The flexible retaining element having a cross-sectional profile with a first width at a side closer to the lip, and a second width at a side farther from the lip, the first width being larger than the second width.

A drain cassette for a dialysis unit has a fluid channel between venous and arterial connection ports, and a valve may controllably open and close fluid communication between a drain outlet port and the venous connection port or the arterial connection port. A blood circuit assembly and drain cassette may be removable from the dialysis unit, e.g., by hand and without the use of tools. A blood circuit assembly may include a single, unitary member that defines portions of a pair of blood pumps, control valves, channels to accurately position flexible tubing for an occluder, an air trap support, and/or other portions of the assembly. A blood circuit assembly engagement device may assist with retaining a blood circuit assembly on the dialysis unit, and/or with removal of the assembly. An actuator may operate a retainer element and an ejector element that interact with the assembly.

A method is provided for detecting leaks in a disposable medical fluid cassette that includes a base and a flexible membrane attached to the base in such a way that the base and the flexible membrane cooperate to at least partially form a fluid passageway. The method includes applying a first force to the flexible membrane, measuring a first physical property of a system that includes the medical fluid cassette a medical fluid pumping machine, removing the first force from the flexible membrane, applying a second force to the flexible membrane, measuring a second physical property of the system, and determining whether the medical fluid cassette leaks based on a comparison of the first physical property and the second physical property.

A pump set for use with a pumping apparatus includes tubing for carrying a liquid. A valve mechanism is mounted to the tubing between an inlet section and a pump engagement section. The valve mechanism includes a first port connected to the inlet section of the tubing, a second port connected to the pump engagement section of the tubing, and a valve disposed between the first and second ports. The valve includes a stem rotatably mounted within a stem holder. The stem includes a flow passage extending through the stem and having an open V shape whereby a narrow open end of the flow passage communicates with the first port and a wide open end of the flow passage communicates with the second port to place the inlet section of the tubing in communication with the pump engagement section of the tubing.

A dry powder inhaler including replaceable cartridges containing a dry powder for local or systemic delivery through the pulmonary tract and lungs is disclosed. The inhalers are used with inhalable dry powders, including medicament formulations comprising active agents for local or systemic delivery and for the treatment of diseases such as, pulmonary hypertension, cardiovascular disease, anaphylaxis, diabetes, obesity, cancer, and other diseases, or symptoms associated with these and other diseases, such as nausea, vomiting, pain and inflammation.

A medical infusion fluid handling system, such as an automated peritoneal dialysis system, may be arranged to de-cap and connect one or more lines (such as solution lines) with one or more spikes or other connection ports on a fluid handling cassette. This feature may reduce a likelihood of contamination since no human interaction is required to de-cap and connect the one or more lines and the one or more spikes. For example, the automated peritoneal dialysis system may include a carriage arranged to receive the one or more lines each having a connector end and a cap. The carriage may move along a first direction so as to move the connector ends of the one or more lines along the first direction, and a cap stripper may be arranged to engage with the caps on the the one or more lines on the carriage. The cap stripper may move in a second direction transverse to the first direction, as well as to move with the carriage along the first direction.

A pump cassette comprising an outer flexible membrane covering flowpaths, valve chambers and pump chambers of the cassette is designed to be actuated by a control gasket on a base unit arranged to move designated valve and pump portions of the cassette membrane. The performance of a cassette valve may improved by optimizing the configuration of the valve control region of the control gasket overlying the cassette valve. This may improve both fluid flow through the valve and reduce the amount of vibratory noise associated with opening the valve. The gasket valve control or actuation region is at least partially bounded by a vacuum channel facing the outside of the gasket so that a constant vacuum can be applied between the gasket valve control or actuation region and the adjacent portion of the cassette membrane. An improved version of the vacuum channel comprises a flexible inner wall (contiguous with the valve control region) so that the inner wall flexes or partially collapses away from the cassette valve seat, while still maintaining patency of the vacuum channel during the application of negative pressure on the gasket valve actuation region to open the cassette valve.

Various aspects of the subject disclosure relate to a compounder system having a cartridge that includes controllable fluid pathways. One or more rotary piston pump/valves may be used to move fluid and/or gasses through the various fluid pathways of the cartridge. For example, the cartridge may include a dedicated rotary piston pump/valve for each process that moves fluid and/or gas through the cartridge. When turning, the rotary piston pump/valve acts as a pump to move the fluid or gas, and when the rotary piston pump/valve stops turning, it effectively acts as a shutoff valve, preventing any fluid flow. Magnetic couplers for the cartridge may be provided on a pump head of the compounder system.

An auto injector for delivery of administering a medicament comprising: a housing; an electrical motor adapted to move a piston between proximal and distal positions in a longitudinal direction of the auto injector; a syringe holder extending from a proximal to a distal end and configured to receive a syringe, a first spring adapted for moving the syringe holder with the syringe proximally for insertion of the needle; wherein the electrical motor is the only motor in the auto injector.

A drug delivery device comprising a first module comprising a zinc-air cell located at one end of the first module, a second module for attachment to the one end of the first module and comprising electronics, and activation means for activating the zinc-air cell and being designed such that at least one air hole is created in an air tight sealing of the zinc-air cell when the second module is attached to the one end of the first module.