Systems and methods for generating nitric oxide are disclosed. A nitric oxide (NO) generation system includes at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas; and a controller configured to regulate the amount of nitric oxide in the product gas produced by the at least one pair of electrodes by utilizing duty cycle values of plasma pulses selected from a plurality of discrete duty cycles to produce a target rate of NO production based on an average of discrete production rates associated with each of the plurality of discrete duty cycles.

A therapeutic device for extended release drug delivery including a refillable reservoir configured to receive a therapeutic agent and having an outlet for delivery of the therapeutic agent to a patient from the reservoir over an extended period. A porous structure is coupled near the outlet of the reservoir, the porous structure formed of sintered material. A barrier layer is coupled to the reservoir on or adjacent a surface of the porous structure such that the therapeutic agent passes through both the porous structure and the barrier layer upon delivery from the reservoir through the outlet. The porous structure is tuned to deliver the therapeutic agent at a diffusion rate and the barrier layer is adapted to block passage of particles having an average particle size within an average particle size range that is outside an average particle size range blocked by the porous structure. Related methods and systems are provided.

An ultraviolet disinfecting cartridge system utilizes an ultraviolet disinfecting cartridge particularly adapted for coupling with a face mask that covers the nose and mouth or to the inhale and exhale tubing of a patient ventilator. The ultraviolet disinfecting cartridge includes multiple UV light emitters that emit UVGI light into the flow channel of the cartridge to neutralize or destroy pathogens. A plurality of baffles may be configured in the flow channel to create a serpentine airflow to increase pathogen exposure time to UV light. A photocatalyst material such as titanium oxide may be configured within the flow channel that is activated by UV light to increase disinfection. An ionizer may be configured proximal to the inlet to produce charged particles that provide disinfection. Any ozone produced may be mitigated by a catalytic converter to a safe level. Inlet and outlet filters may be detachably attachable to the ultraviolet disinfecting cartridge.

In a pulmonary ventilation system, a filter arrangement useful as an input filter arrangement and an output filter arrangement is constructed to allow for changing or cleaning of the filter without interrupting or impacting the ventilation therapy and to limit the release of pathogens to the surrounding area or atmosphere. A preferred exhaust filter is constructed to function as a water trap and filter. Methods of operating the pulmonary ventilation system are also disclosed along with kits containing materials to construct an input or an output filtration structure.

A humidifier is provided with a water storage tank, a second housing to which the tank is detachably mounted, and a heater for vaporizing water stored in the tank. The tank is configured with a tank body having a space therein, and a partition wall rising from an inner surface of the tank body. A first tank hole that causes an inside and an outside of the tank body to communicate with each other opens in the tank body. The partition wall partitions the space inside the tank body into a water storage space for storing water, and a trap space. The trap space communicates with an outside of the tank via the first tank hole, and communicates with the water storage space.

Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO.sub.2 gas analysis sensors without the use of a calibration gas.

Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.

The invention relates to systems and methods for generation and use of peritoneal dialysis fluid. The peritoneal dialysis fluid is generated by dissolving solids or diluting concentrated liquids in a single container having all components of the final peritoneal dialysis fluid.

A manifold for a medical waste collection apparatus includes a fluid path connection portion and a storage connection portion. The storage connection portion includes a mounting connector in communication with the fluid path connection portion and coupled with the mounting base of the waste collection apparatus, and a docking valve arranged inside a connector cavity defined by inner walls of the connector. The docking valve is in an open state when the mounting connector is coupled with the mounting base, and a passage is formed between the storage connection portion and a waste collection container in the waste collection apparatus. The docking valve is in a closed state to close the connector cavity when the mounting connector is decoupled. The connection port between the manifold and the apparatus does not require manual opening or closing, thereby preventing waste from contaminating the environment, equipment and personnel, and enhancing convenience of use.

In some embodiments, a system includes a cartridge assembly and a pen assembly. The cartridge assembly includes a mouthpiece assembly and a bracket cartridge assembly. The mouthpiece assembly includes a mouthpiece component defining a mouthpiece opening and an outer housing defining a vapor outlet and including a recessed sidewall portion. The pen assembly includes a pen housing and a bracket assembly configured to engage with the bracket cartridge assembly of the cartridge assembly such that a temperature of a coil of a wick assembly of the cartridge assembly may be increased such that a carrier material disposed near the coil may be vaporized by the coil. When the cartridge assembly is engaged with the pen housing, the recessed sidewall portion of the outer housing and an inner surface of the pen housing form a fluid path from the vapor outlet to the mouthpiece opening.