A peritoneal dialysis system includes a control unit is programmed to cause (i) a pressure sensor to take a first pressure reading of a reference chamber with a pneumatic valve closed, (ii) a pump actuator to pump fresh dialysis fluid through a fresh dialysis fluid pathway into a patient line expandable chamber, expanding the expandable chamber into a dome, (iii) the pneumatic valve to open, allowing the reference chamber to communicate pneumatically with any air in the dome, (iv) the pressure sensor to take a second pressure reading with the pneumatic valve open, (v) the first and second pressure readings to be used with the ideal gas law to determine an amount of air in the dome, and (vi) the amount of air in the dome and a known volume of the dome to be used to determine an amount of fresh dialysis fluid delivered into the expandable chamber.

Rotary microfluidic medical pump and pumping method embodiments are discussed herein that may be used for controlled delivery of small and precise volumes of therapeutic or non-therapeutic fluids in a variety of environmental conditions. Certain medical pump and pumping method embodiments discussed herein may also include pump systems having a plurality of reservoirs and which are configured for pumping a plurality of fluids such as medicaments via a common pump mechanism and outlet tubing.

The invention relates to a dialysis device that provides recirculating flow dialysis in a wearable and portable format. It uses an exchangeable purification unit holding a volume of dialysate and/or a sorbent system for the in-situ regeneration of dialysate. The invented dialysis device comprises a carrier that is mounted on a replaceable cartridge. The carrier holds the electronics, user-interface, actuators and sensors. It actuates, controls and monitors the dialysis operation. The cartridge is a replaceable part that is connected to the patient via a flexible tubing. It consists of a reusable housing with a memory chip and holds a disposable inlay containing the purification unit with fluid lines, connectors, dialysate and/or sorbents in combination with a nanofilter. The cartridge is intended for use during the day, as a wearable system. The cartridge can be enlarged with an extension set to offer more capacity. The extended cartridge is intended to be used during the night as a bedside device.

An infusion cassette of an infusion set is provided with a flow channel, and includes a rigid assembly, elastic membranes and a locking mechanism. The rigid assembly includes a plurality of components stacked onto one another, at least one of the components is provided with a groove, and the elastic membranes are each arranged between two adjacent components to cover the groove in a sealing manner; and the locking mechanism includes a mounting frame and a liquid stop plug fixedly arranged on the mounting frame, and configured to press the elastic membranes to close the flow channel, the locking mechanism closes or opens the flow channel by the liquid stop plug. The mounting frame is movably connected to the rigid assembly, such that the locking mechanism is switched between a closed state in which the flow channel is closed and an open state in which the flow channel is opened.

A clamping module of or for a medical pump, and a method for identifying a hose clamp of a disposable infusion article insertable into the clamping module. The clamping module includes an electro-optical system for identifying the hose clamp, which has an optical marking. The electro-optical system includes a first light source for emitting at least a first light beam and a second light source for emitting at least a second light beam. The second light source is formed differently than the first light source. A photodetector receives a reflected light, and an optical window bundles the first light beam and/or the second light beam on the disposable infusion article, as well as the reflected light received by the photodetector. The method identifies the hose clamp based on a color and uses a measurement algorithm after insertion of the hose clamp into the medical pump.

In one aspect, a peritoneal dialysis (PD) system includes a housing that receives a disposable cassette, a plurality of pinch valves that receive respective sections of fluid tubing of the disposable cassette, an air port that forms an airtight seal with an air line of the disposable cassette, an air pump that alternatingly pushes air out of the air port and pulls air in from the air port, and a computer processor that controls the plurality of pinch valves and the air pump such that the cassette performs a dwell phase in which the diaphragm pump pumps fresh dialysate from a dialysate bag to a heater bag, a fill phase in which the diaphragm pump pumps the fresh dialysate from the heater bag to a patient line, and a drain phase in which the diaphragm pump pumps spent dialysate form the patient to a drain.

Aerosolizing delivery apparatuses can include cartridges configured to be detachably connected to a delivery device. The cartridges can include: a housing defining a reservoir and a cartridge outlet, the cartridge outlet configured to permit fluid communication between the reservoir and an exterior of the cartridge. A surface of the housing can be configured to define a bypass port between the housing and a surface of the delivery device when the cartridge is assembled with the delivery device.

A sample collection and testing device for analyzing blood is provided that includes a controller, a fluid flow pathway, a pump configured to move fluid through the fluid pathway, and an optical fluid measurement element configured to measure a light intensity of the fluid in the fluid flow pathway. The controller is configured to: start the pump to move a blood sample in the fluid flow pathway, receive a signal from the optical fluid measurement element indicating a detection of a leading edge of the blood in the fluid flow pathway, stop the pump to stop the moving of the blood in the pathway, receive a plurality of light intensity measurements from the optical measurement element, each light intensity measurement measured at a corresponding point of time, and provide a mapping of the light intensity measurements into an indication of a coagulation of the blood sample over a time period.

A fluid handling cassette, such as that useable with an automated peritoneal dialysis (APD) cycler device or other infusion apparatus, may include a generally planar body having at least one pump chamber formed as a depression in a first side of the body and a plurality of flowpaths for a fluid that includes a channel. A patient line port may be arranged for connection to a patient line and be in fluid communication with the at least one pump chamber via at least a first one of said flowpaths, and an optional membrane may be attached to the first side of the body over the at least one pump chamber. In one embodiment, the membrane may have a pump chamber portion with an unstressed shape that generally conforms to the depression of the at least one pump chamber in the body and is arranged to be movable for movement of the fluid in a useable space of the at least one pump chamber. One or more spacers may be provided in the at least one pump chamber to prevent the membrane from contacting an inner wall of the at least one pump chamber. The patient line, a drain line, and/or a heater bag line may be positioned to be separately occludable in relation to one or more solution lines that are connectable to the cassette.

An aerosol delivery device includes at least one housing structured to retain an aerosol precursor composition, and an atomizer. A microprocessor is configured to operate in an active mode in which the control body is configured to control the atomizer to activate and produce an aerosol from the aerosol precursor composition. A heart rate monitor is configured to obtain biopotential measurements from a user, the biopotential measurements forming an identifier of the user. The microprocessor is operably coupled with the heart rate monitor and is configured to perform a biometric authentication of the user based on the identifier, and to control operation of at least one functional element of the aerosol delivery device based on the biopotential measurements, with the controlling operation of at least one functional element including altering a locked state of the aerosol delivery device based on the biometric authentication.