The invention relates to a single-use cassette assembly for use in a reusable solid dose formulation delivery actuator device. Such improvements permit delivery of at least one therapeutic or prophylactic compound, or a solid dose formulation including, for example, a vaccine comprising the same with improved safety and reliability. The invention further concerns an improved needle-free method for delivering at least one therapeutic compound or a formulation comprising the same.

The present disclosure relates to a syringe safety cap and a safety syringe including the same. One aspect of the present disclosure provides a syringe safety cap including a base portion having a mounting portion to be mounted on a cylinder of a syringe, a link portion rotatably connected to the base portion, a first elastic portion configured to provide a rotational force so that the link portion rotates with respect to the base portion, a safety cover portion rotatably connected to the link portion, detachably fixed to the base portion, and configured to, when detached from the base portion and rotating, surround an injection needle of the syringe, and a second elastic portion configured to provide a rotational force so that the safety cover portion rotates with respect to the link portion.

A method and system for detecting a limit of use of a medical device is disclosed. The method includes starting a timer of a medical device when said medical device is used for the first time, detecting the limit of use of the medical device and indicating the limit of use of the medical device. The limit of use is reached when at least one of a first criterion and a second criterion is met, wherein the first criterion is that the timer reaches or exceeds a time limit and wherein the second criterion is that at least one operation of a drive train of said medical device reaches or exceeds a limit.

The present invention relates to drug delivery systems that cannot be reloaded or reused and further include a passive safety shield system. The drug delivery devices described herein comprise a drug container comprising at least one bellow, wherein the at least one bellow comprises a first surface and an opposing second surface, wherein the first surface is comprised of a first Belleville spring and the opposing second surface is comprised of a second Belleville spring, wherein the second Belleville spring has a higher spring rate than the first Belleville spring; or a drug container extending between distal and proximal ends, and comprises a continuous change in cross section from proximal end to distal end; a needle, wherein the needle is in liquid communication with the drug container; a plunger extending between a proximal end and a distal end, wherein the plunger is in communication with the drug container and where upon axial movement of the punger, the drug container is compressed; a main body extending between a proximal end and a distal end and comprising an inner body and an outer body, wherein the inner body houses the plunger and the drug container and the outer body is capable of sliding over the inner body and extending past the needle; and a spring located between the inner body and the outer body for urging the outer body to slide over the inner body and extend past the needle.

There is provided a protected needle assembly. The assembly includes an outer barrel receiving a needle therethrough. The assembly includes an inner barrel resiliently biased to extend about the needle in a protected needle mode. The inner barrel is retractable into the outer barrel in a first instance to deploy the needle. The assembly includes a locking mechanism actuated upon the inner barrel moving towards the protected needle mode once more. The locking mechanism is configured to inhibit further retraction of the inner barrel thereafter.

A cuff pressure stabilizer (100, 200, 300, 500, 600, 800) is provided that includes an inflation lumen proximal port connector (134), which is shaped to form an air-tight seal with an inflation lumen proximal port (15) of a catheter (10) additionally having an inflatable cuff (11) and an inflation lumen (13); a fluid reservoir (120, 524, 624); a liquid column container (118, 518, 618), which is (a) open to the atmosphere (99) at at least one site along the liquid column container, (b) in fluid communication with the fluid reservoir (120, 524, 624), and (c) in communication with the inflation lumen proximal port connector (134) via the fluid reservoir (120, 524, 624); and a liquid (121), which is contained (a) in the fluid reservoir (120, 524, 624), (b) in the liquid column container (118, 518, 618), or (c) partially in the fluid reservoir (120, 524, 624) and partially in the liquid column container (118, 518, 618), and which has a density of between 1.5 and 5 g/cm3 at 4 degrees Celsius at 1 atm.

Electronic modules for attachment to a drug delivery device include delivery status sensing means (21, 22) for monitoring a delivery status of the device, a status indicator (25) with an indicator element controllable to indicate a delivery or module status, and a status indicator controller (23), which generates an indicator control signal on behalf of the status indicator element, which in turn produces a status signal. The indicator control signal has an amplitude varying monotonically in time between a minimum value and a maximum value in a first interval of a base cycle, and between the maximum value and the minimum value in a second interval of the base cycle. In at least one of the first and the second interval, the mean value of the indicator control signal is below the average of the maximum and the minimum values of the indicator control signal to realize increased energy savings.

A syringe with passive needle protection for administering a medicament dose to a patient, comprising a hollow body forming the syringe housing and containing the medicament active substance, at the distal end of which a hollow needle provided for injection of the active substance is mounted in a bearing sleeve, and in which a displaceable plunger provided at the end with a receiving hole for the hollow needle is arranged, for the most complete possible delivery of medicament while avoiding undelivered medicament residues. For this purpose, the piston is designed in several parts; in addition to a needle holder having a retaining clip for the hollow needle, it comprises a piston jacket which is shaped such that, when the needle holder is inserted, it leaves free inflow channels into the enclosed end of the hollow needle for the active substance on both sides of the retaining clip.

An injector comprises a medicament container, an injection module and a driving mechanism. The injection module comprises a conversion mechanism and a needle output mechanism connected to each other. The conversion mechanism is assembled and connected to the medicament container. A driving piston set in the conversion mechanism is assembled and connected to the driving mechanism. A needle set in the needle output mechanism is used for piercing a human body. The driving mechanism drives the driving piston set to convey a medicament liquid in the medicament container to the needle set for injection, such that the medicament container and the injection module, which are related to safety and hygiene, are of single use and are disassembled and discarded after being used. The conversion mechanism is externally connected to the driving mechanism, so that the driving mechanism does not contact the injection medicament liquid during injection and can be reused, thereby reducing material waste.

Various exemplary drug syringes with a mechanical stop for a second dose, drug products utilizing the same, and methods of using drug syringes with a mechanical stop for a second dose are provided. In general, a nasal drug delivery device is configured to dispense therefrom first and second doses of a drug therefrom into a nose. The drug delivery device includes a mechanical stop configured to provide a pause between the delivery of the first and second doses. During the pause, a user of the drug delivery device can move the drug delivery device from one nostril, into which the first dose was sprayed, to another nostril, into which the second dose can be sprayed. The mechanical stop is configured to hold the drug delivery device in a static delivery state.