Systems tune, control, or remediate the intrinsic Circadian clock. A light controller sets spectral distribution, intensity of a bioactive spectral band to shift or entrain circadian response to enhance performance and/or synchronize with local or expected conditions. The systems enhance performance under conditions that might be changing, disrupted, or otherwise present an irregular phase or unnatural change in the subject's circadian status, for example, due to geographically discontinuous activity or spectrally deficient workplace illumination, or due to divergent individual sleep/wake behaviors of subjects in a structured group activity. An illumination recipe that compensates for the deficiency of lighting or of participant sleep or behavior patterns, or age- or disease-related changes, to evoke, shift, or align circadian response and improve behaviors such as classroom alertness, relaxation, excitability, attention, or focus. Systems may receive sensed light values and automatically apply high- and/or low-CER illumination to effect the intended circadian phase.

An apparatus for controlling positioning of a subject's jawbone including an expandable device expandable to apply a force on the subject's jawbone in a direction of an anterior position with respect to a subject's skull; a mounting device holding the expandable device in proximity to the subject's jawbone to facilitate application of the force on the subject's jawbone and configured to position the expandable device behind the subject's jawbone such that application of the force on the subject's jawbone rotates the subject's jawbone relative to the subject's skull towards the anterior position; and a control system configured to control the force in response to the control system receiving an indication of a change in at least one of: an oxygen level of the subject; a gas flow rate of therapy gas supplied to the subject; a position and/or orientation of the subject; and/or a sleep state of the subject.

A method includes applying, via a respiratory therapy system, initial therapy settings for a user during a first sleep session in which the user uses the respiratory therapy system. First physiological data, which is received from one or more sensors, is generated during the first sleep session. Modified therapy settings are applied, via the respiratory therapy system, during a second sleep session of the user. Second physiological data is received from the one or more sensors. The second physiological data is generated by the one or more sensors during the second sleep session. A set of sleep-related parameters is determined based on changes between the first physiological data and the second physiological data. One or more of a recommended therapy or recommended therapy settings is determined based on the set of sleep-related parameters.

A system and method for a cloud-based gaming platform with integrated health-related data collection capabilities. In an embodiment, the system and method comprise a cloud-based gaming platform comprising a frontend accessible from various game clients which operates a gaming environment on one or more game servers, a backend that provides the game database and analytics used by the game servers to operate the gaming environment, and a HIPPA-compliant security gateway configured to route health-related data from gaming to a healthcare diagnostics and treatment module integrated into the platform. Exercising on an exercise machine compatible with the cloud-based gaming platform entertains the user while simultaneously capturing data about the user's physical and mental performance which can later be used to diagnose medical conditions and, depending on configuration, implement treatment regimens comprising exercise routines and mental simulation via tasks in the gaming environment.

Systems and methods are provided for improving efficiency and quality of plasma being removed from a blood separation chamber. The system includes a separation chamber in which plasma is separated from cellular blood components, a pump for moving the plasma and an outlet line for removing the separated plasma from the blood separation chamber. An optical sensor assembly is configured to monitor the blood separation chamber and measure an interface position between the separated component and the plasma, and to generate an output indicative of the measured interface position. A controller is programmed to utilize a lipid concentration input of the blood and to set an original lipemia offset, a lipemia threshold and lipemia final setpoint from a predetermined database, and to use a proportional-integral-derivative control loop to assess the actual interface position plus the lipemia threshold to adjust and achieve a final lipemia setpoint for use during separation procedures.

A medical treatment system, such as a peritoneal dialysis system, may include a control system and other features to enhance patient comfort and ease of use. For example, the peritoneal dialysis system may include the control system that can adjust a volume of fluid infused into a peritoneal cavity to prevent an intraperitoneal fluid volume from exceeding a pre-determined amount. The control system can adjust by adding one or more therapy cycles, allowing for fill volumes during each cycle of the one or more therapy cycles to be reduced. The control system may continue to allow the fluid to drain from the peritoneal cavity as completely as possible before starting the next therapy cycle of the one or more therapy cycles. The control system may also adjust a dwell time of the fluid within the peritoneal cavity during the one or more therapy cycles in order to complete a therapy within a scheduled time period. A cycler may also be configured to have a heater control system that monitors both a temperature of a heating tray and a temperature of a bag of dialysis fluid in order to bring a temperature of the dialysis fluid rapidly to a specified temperature, with minimal temperature overshoot.

Some embodiments are directed to an adherence monitor for use with a tethered cap inhaler device. The adherence monitor engages the inhaler device, and includes a tether opening located within a housing of the adherence monitor for receiving the tether. The tether opening is in the form of a slot in a base portion of the housing. The path length of the tether around the adherence monitor is kept from being increased, compared to its path length when the adherence monitor is not attached to the inhaler, by having the slot located to allow the tether to pass through the slot. Various sensors of the adherence monitor in various embodiments detect inhaler usage.

An intubation assistance device includes an electronic controller configured to: generate a patient respiratory tract geometry model of at least a portion of a human respiratory tract by inputting one or more patient variables into a statistical shape model (SSM) of at least a portion of the human respiratory tract; select a recommended endotracheal tube (ETT) size by modeling at least one ETT model inserted into the patient respiratory tract geometry model to form a virtual fit model and estimating at least one fit parameter based on the virtual fit model; and display the recommended ETT size on a display device.

A filter apparatus for removing small molecule chemotherapy agents from blood is provided. The filter apparatus comprises a housing with an extraction media comprised of polymer coated carbon cores. Also provided are methods of treating a subject with cancer of an organ or region comprising administering a chemotherapeutic agent to the organ or region, collecting blood laded with chemotherapeutic agent from the isolated organ, filtering the blood laden with chemotherapeutic agent to reduce the chemotherapeutic agent in the blood and returning the blood to the subject.

A bougie is disclosed with a body, and a first depth indicator and a second depth indicator on the body. The body has a first end, a second end, and at least one surface extending between the first and second ends. The first depth indicator is spaced a first distance from the first end and indicates a first predetermined depth range such that the first end is positioned a first predetermined insertion range past the mouth of the patient when the body is positioned into the mouth of the patient. The second depth indicator is spaced a second distance from the second end and indicates a second predetermined depth range such that the second end is positioned a second predetermined insertion range past the mouth when the body is positioned into the mouth of the patient.