A system for treating heart disease, such as pulmonary hypertension or right heart failure, including an implantable component and external components for monitoring the implantable component is provided. The implantable component may include a compliant member, e.g., balloon, coupled to a reservoir via a conduit. Preferably, the compliant member is adapted to be implanted in a pulmonary artery and the reservoir is adapted to be implanted subcutaneously. The external components may include a clinical controller component, monitoring software configured to run a clinician's computer, a patient monitoring device, and a mobile application configured to run on a patient's mobile device.

Systems, apparatuses, and methods for providing negative pressure with instillation fluids to a tissue site are disclosed. Some embodiments are illustrative of an apparatus or system for delivering negative-pressure and/or therapeutic solution of fluids to a tissue site, which can be used in conjunction with sensing properties of fluids extracted from a tissue site and/or instilled at a tissue site. For example, a system may comprise a tissue interface adapted to be coupled to a source of instillation fluid and a dressing interface having a therapy cavity that includes a pH sensor, a humidity sensor, a temperature sensor, and a pressure sensor embodied on a single pad within the dressing interface to provide data indicative of acidity, humidity, temperature and pressure at the tissue site. Such apparatus may further comprise algorithms for processing such data for detecting leakage and blockage conditions as well as providing information relating to the progression of healing of wounds at the tissue site. An illustrative method may comprise disposing the tissue interface at the tissue site and the therapeutic cavity in fluid communication with the tissue interface. The method may further comprise instilling fluid to the therapy cavity and then sensing the pressure, humidity, temperature, and the pH of the fluids adjacent the tissue interface. The method may further comprise determining various flow characteristics of the system by using a processing element electrically coupled to the sensors for transmitting property signals from the sensors to a controller configured to assess the property signals in order to identify the flow characteristics.

Described herein are noninvasive electrical stimulation devices, systems and methods for stimulation of the Vagus nerve through its auricular branch to provide beneficial physiological responses in subjects, including alleviation, mitigation or elimination of symptoms of various disorders, including metabolic and inflammatory disorders.

A wound irrigation system and method of making and using. The system uses a pored, closed-ended delivery conduit to enhance the consistency and speed with which anti-microbial or related irrigation fluids may be delivered in order to promote cleansing, debridement and biofilm reduction in wounds. The ease of use of the system as a moist wound healing cascade makes it applicable to both in-home and in-facility environments that is not offered through traditional instillation negative pressure systems. In one form, the fluid delivery conduit is used as part of a dual-conduit approach in order to also help promote the removal of drainage, waste, irrigation overflow or other fluid from the wound. Utilization of such a pored, closed-ended delivery conduit in conjunction with a separate drainage conduit infusing helps reduce the frequency of dressing changes as well as the likelihood of microorganism formation and colonization.

In general, drug administration devices configured to communicate with networks and external devices are provided. In an exemplary embodiment, a drug administration device is configured to adjust an operational parameter of the drug administration device based on a data packet formed from drug administration data ancillary data received from networks and/or external devices. In another example embodiment, a drug administration device is configured to scan for and establish communications with at least one external device. In another example embodiment, a method includes assessing whether to update a control program on a drug administration device from a network or external device. In another example embodiment, a system includes a first drug administration device configured to communicate with a second drug administration device to optimize a drug treatment.

Systems and methods for managing the pH of a dialysate fluid during hemodialysis therapy. The systems and methods adjust dialysate pH and buffer concentration to generate a predetermined total bicarbonate buffer concentration in a dialysate entering a dialyzer.

A pump cassette is disclosed. The pump cassette includes a housing having at least one fluid inlet line and at least one fluid outlet line. The cassette also includes at least one reciprocating pressure displacement membrane pump within the housing. The pressure pump pumps a fluid from the fluid inlet line to the fluid outlet line. A hollow spike is also included on the housing as well as at least one metering pump. The metering pump is fluidly connected to the hollow spike on the housing and to a metering pump fluid line. The metering pump fluid line is fluidly connected to the fluid outlet line.

Systems, apparatuses, and methods for providing negative pressure to a tissue site are disclosed. Some embodiments are illustrative of an apparatus or system for delivering negative-pressure to a tissue site that can be used in conjunction with sensing properties of fluids extracted from a tissue site. For example, an apparatus may comprise a dressing interface or connector that includes a pH sensor, a humidity sensor, a temperature sensor and/or a pressure sensor embodied on a single pad within the connector and proximate the tissue site to provide data indicative of acidity, humidity, temperature and pressure. Such apparatus may further comprise an ambient port for providing the pressure sensor and the humidity sensor with access to the ambient environment providing readings relative to the atmospheric pressure and humidity.

The present disclosure is directed to a bedding panel system comprising a bottom or fitted sheet with embedded channels throughout such that at least one or more modular top panels and cushions can be attached to create physical sleep chamber spaces and thus independent “sleep zones” for multiple occupants on a single mattress. A bedding panel system can have dimensions to fit any size mattress. Fitted sheet, modular panels and cushions can include several layered components, each with comfort or utility features for each sleep chamber space. Top and bottom layers of fitted sheet and modular panels may be comprised of various fabrics and materials desirable for sleep comfort. Middle layers of fitted sheet and modular panels can include items such as foam or gel padding, moisture resistant barriers, biometric sensors for measuring physical health and sleep quality, and hardware for heating and cooling. Customized foot panels with specialized materials and electronic components can also be attached to fitted sheet for elevated comfort in the foot box. Bedding panel system components can be embedded with channels, arranged in crisscross and diagonal patterns, containing reinforced holes spaced symmetrically throughout to accommodate different configurations for modular panel and cushion installations. Anchor systems can include a variety of material and hardware combinations to enable ease of component connections, sleep comfort, and convenience of occupant access to sleep zones. Similar to modular panel configurations, anchors allow cushions, pillows, pillow cases and similar headrests designed for the head box section to remain connected to fitted sheet to ensure sleep materials remain intact and in place for the duration of the occupants sleep session.

A mechanical kidney transplant designed may include a four modules designed to interconnect to clean blood. The first module may include a plurality of pump modules and a resin gel regeneration module, wherein the first module is operatively attached to a patient's iliac artery, iliac vein, and bladder. The second module may be operatively attached to the first module and may include storage and pump systems. The third module may be operatively attached to the first and fourth modules and may include a housing with ports for inflow/outflow of the blood and the physiologic resin gel between the first module and the fourth module. The fourth module may include at least one dialyzer fiber sized to accommodate a volume of blood flowing therethrough and an area surrounding the dialyzer fiber may be sized to accommodate a volume of a physiologic resin gel flowing counter current to the blood.