A method of performing a dialysis treatment includes using a pump and a dialysate supply line to transport peritoneal dialysis fluid, the supply line having a proximal end into which peritoneal dialysis fluid is supplied and from which spend dialysate is withdrawn, and a distal end which is connected to a patient's peritoneal access. The method further includes generating proximal and distal pressure signals using pressure detectors located at both the proximal and distal ends, respectively, of said supply line. During a drain cycle in which spent dialysate is pumped from the patient, the method includes, responsively to the proximal and distal pressure signals, detecting a characteristic of a pressure difference between the distal and proximal ends whose magnitude is determined by a predicted change in dialysate properties, and responsively to the characteristic, generating a signal indicating the change in dialysate properties.

A renal failure therapy system having an electrically floating fluid pathway is disclosed. The example system includes a dialyzer, a blood circuit in fluid communication with the dialyzer, and a dialysis fluid circuit in fluid communication with the dialyzer. The system also includes an electrically floating fluid pathway comprising at least a portion of the blood circuit and at least a portion of the dialysis fluid circuit. The only electrical path to ground is via used dialysis fluid traveling through the renal failure therapy system to earth ground. The disclosed system enables at least one electrical component in the at least a portion of the dialysis fluid circuit of the electrically floating fluid pathway to be electrically bypassed.

A method for needle-free injection and a needle-free injector device are provided. The method includes automatically injecting an injectable into a surface in contact with the needle-free injector in response to a skin compression parameter of an end of the needle-free injector. A needle-free injector device (102) includes predefined structures formed on it to inject an injectable through a non-porous material. The predefined structures engage an airlock mechanism such that an airlock in the non-porous material and operably coupled to the airlock mechanism can only be opened and closed to enable needle-free injection through the non-porous material without disrupting an integrity of the non-porous material by the needle-free injector device. Other functions, embodiments and methods for using and programming the needle-free injector device are also provided.

A droplet delivery device with an ejector mechanism and fluid reservoir includes an accelerometer to determine and communicate optimized mixing of fluid in the reservoir for inhalation of droplets, such as into the lungs, from the droplet delivery device.

Impact testing apparatuses are disclosed which simulate and measure various impact-related events associated with the operation of a drug delivery device. The impact testing apparatus may include an impactor configured to simulate a plunger rod of the drug delivery device, and a guide sleeve configured to receive a syringe corresponding to the drug delivery device. The syringe may have a proximal end, a distal end defining an outlet, and an interior chamber extending between the proximal and distal ends and carrying a plunger. Additionally, the impact testing apparatus may include an energy source configured to reduce a distance between the impactor and the plunger so that the impactor strikes the plunger. Various sensors may be included to measure characteristics of one or more impacts caused by the impactor. Methods of impact testing a syringe filled with a fluid and carrying a plunger are also disclosed.

An exhaust gas flow control system for an oxygenator of an extracorporeal ventilation system connected to an oxygenation gas supply line and to an exhaust line for removal of exhaust gas comprises a flow control path, a pressure control path, an exhaust flow regulator responsive to the controller, and an exhaust gas pressure regulator responsive to a controller configured to maintain a pre-determined pressure level in the exhaust line. This provides a better degree of control over the pressure across the oxygenator from oxygenation gas inlet to exhaust.

A disposable cell enrichment kit includes a crossflow filtration device configured to be disposed along a main loop pathway and to receive a process volume containing a biological sample and utilize crossflow filtration, via a micro-porous membrane, to retain a specific cell population in a retentate from the process volume and to remove a permeate including certain biological components from the process volume. The crossflow filtration device includes a laminated filtration unit that includes the micro-porous membrane, a first mating portion, a second mating portion, and a membrane support. The membrane support includes a first plurality of structural features that define a first plurality of openings, wherein the first plurality of structural features are coupled to the micro-porous membrane and provide support to the micro-porous membrane, and the first plurality of openings allow the permeate to flow through them after crossing the micro-porous membrane.

Sleep performance systems and methods of using the same are disclosed. The sleep performance systems can improve the quality of sleep by making one or more recommendations to the subject for increasing a sleep quality score. The sleep performance systems can have one or more electroencephalography (EEG) electrodes configured to measure a subject's brain activity during sleep. The sleep performance systems can have a processor configured to quantify the quality of the subject's slow-wave sleep by determining one or more sleep performance scores associated with the measured brain activity. The sleep performance systems can recommend and/or activate sleep improvement programs based on various threshold scores.

A medical treatment system for determining administration of medications to a patient is disclosed. The system uses a plurality of sensors to perform a first set of physiologic measurements in a right side of the heart and a second set of physiologic measurements in a left side of the heart. The system also includes a receiver configured to receive measurement data regarding the first and second sets of physiologic measurements and output to a display device the received measurement data.

Sensing systems, connectors, and methods include a housing, including a sensor and a locking mechanism, a junction, and a membrane. The junction includes a fluid inlet, a fluid outlet, and a receiving mechanism. The receiving mechanism is removably attachable to the locking mechanism. The membrane is disposed within the junction, and is in fluid communication with the fluid inlet and the fluid outlet. The sensor senses a property of a fluid across the membrane when the locking mechanism is attached to the receiving mechanism.