A peristaltic pump-based apparatus for capturing circulating tumor cells (CTCs) from blood is provided that includes a feedback control architecture that uses models of pump operation and measures of internal pressure fluctuations of the pump (e.g., in the form time-varying and/or position-dependent pressure oscillation data) to adjust pump operating characteristics that smooth pump operation, thereby improving viscosity and consistency of fluid flowing through the pump to a connected microfluidic capture device.

Described is a system including an air pressure supply arrangement, a sensor and a titration device. The air pressure supply arrangement provides air pressure to a patient's airways. The sensor detects input data corresponding to a patient's breathing patterns of a plurality of breaths. The titration device receives and analyzes the input data to determine existence of breathing disorder and corresponding characteristics. The titration device generates output data for adjusting the air pressure supplied to the patient as a function of an index of abnormal respiratory events included in the input data.

A fill adapter system for an infusion pump assembly. The system includes a reusable fill adapter base, the base including a volume control mechanism to adjust an available fill volume of a reservoir of the infusion pump assembly and a pump mechanism configured to pump air into a fluid vial. The system also includes a vial adapter assembly including a first needle configured to penetrate a septum of the fluid vial for fluidly coupling the pump mechanism to the fluid vial and a second needle having a first end configured to penetrate the septum of the fluid vial and a second end configured to penetrate a septum of the reservoir of the infusion pump assembly to allow transfer of fluid from the fluid vial to the reservoir of the infusion pump assembly in response to air being pumped into the fluid vial and a needle carriage adapted to carry the first needle and the second needle, wherein the needle carriage slidably attached to the interior of the vial adapter assembly, wherein the needle carriage adapted to slide from a vial end of the vial adapter to a receptacle end of the vial adapter.

Systems and methods for delivering a drug or other therapy over an extended period of time (e.g., several hours, days, weeks, months, years, and so forth) are disclosed herein, as are systems and methods for monitoring various parameters associated with the treatment of a patient. Systems and methods are also disclosed herein that generally involve CED devices with various features for reducing or preventing backflow.

A method for anal or stomal irrigation includes providing an irrigation system to a user and instructing the user to operate the system to expel the irrigating liquid from a catheter tip. The irrigation pressure is controlled with the control system in response to input from a sensor such that a pressure at the catheter tip approaches a predetermined threshold pressure value without exceeding the predetermined pressure value.

Systems and methods for pumping milk from a breast, wherein the milk is expressed from the breast under suction and milk is expulsed from the pumping mechanism to a collection container assembly.

A ventilation device for artificially ventilating a patient, the controller of the ventilation device being designed to actuate a flow modifying device for carrying out a P/V maneuver, in which a patient is supplied with respiratory gas while the pressure of the respiratory gas is increased during an inspiration phase, said respiratory gas passively flowing out of the patient during an expiration phase after the pressure increase is terminated. For a plurality of respiratory gas pressures, the respective maneuver respiratory gas volume present in the patient as a result of the P/V maneuver is ascertained in connection with the present respiratory gas pressure during the inspiration phase as well as during the expiration phase; the controller is designed to—ascertaining a sequence of lung compliance values during the inspiration phase on the basis of signals of a flow sensor assembly and a pressure sensor assembly, —ascertain a reference compliance value in accordance with the sequence of compliance values, —on the basis of the reference compliance value, determine a termination compliance value, which differs from the reference compliance value in terms of amount, in the form of a threshold value as a termination criterion for the inspiration phase, and —terminate the inspiration phase if the termination compliance value is reached or exceeded.

The invention relates to an ultrasonic mist inhaler (100), comprising a liquid reservoir structure (2) comprising a liquid chamber (21) adapted to receive liquid to be atomized, a sonication chamber (22) in fluid communication with the liquid chamber (21); wherein the liquid reservoir structure (2) comprises the sonication chamber (22).

The invention relates to an ultrasonic mist inhaler (100), comprising: a mouthpiece (1) for inhaling the mist, a liquid reservoir structure (2) comprising a liquid chamber (21) adapted to receive liquid to be atomized, a sonication chamber (22) in fluid communication with the liquid chamber (21), wherein at least part of the liquid reservoir structure (2) and the mouthpiece (1) form the sonication chamber (22).

An infusion pump can determine and display what the drug load is inside of a patient by taking into account various factors such as drug half-life, pump pauses, and delays while a drug moves from a pump to a patient. A pump can also calculate and provide times when: medication will reach the patient; the drug concentration will reach a specified level; and a physiological response is expected. The pump can compensate for pauses in the delivery—for example, by infusing larger boluses of the drug into the patient within safe boundaries for concentration and timing. The pump can also predict what the drug load or concentration will be in the patient over time after the infusion stops by providing a graph, and in some cases act on such predictions by changing a flow rate or other parameters.