A control circuit for a sensorless implantable blood pump configured to determine mitral valve regurgitation includes processing circuitry configured to generate an estimated blood flow waveform from the sensorless implanted blood pump and generate an alert if between an end period of diastole and a beginning period of systole a measured amplitude of the estimated blood flow waveform does not include an inflection point.

This flavor inhaler is provided with a housing having an air flow path that spans continuously from an inlet to an outlet, and an atomizing part for atomizing an aerosol source without accompanying combustion of the aerosol source, wherein at least one portion of the air flow path is an aerosol flow path which is a flow path for an aerosol generated from the atomizing part, and the air blow resistance of the whole air flow path is not greater than 25 mmAq.

The present invention discloses a pump for measuring a pressure of fluid to be transferred, a fluid transport system using the same, and a method for operating the system. The pump includes a pumping portion alternately generating a positive pressure and a negative pressure; a first diaphragm which is provided on one side of the pumping portion and of which a shape is changed as the positive pressure and the negative pressure are alternately generated; a transport chamber which sucks and discharges a transport target fluid corresponding to the deformation of the first diaphragm; a second diaphragm which is provided on the other side of the pumping portion; a monitoring chamber which is provided on one side of the second diaphragm and of which a pressure changes corresponding to the deformation of the second diaphragm; and a pressure measuring portion measuring a pressure change of the monitoring chamber.

A control body is coupled or coupleable with a cartridge that is equipped with a heating element and contains an aerosol precursor composition, the control body and cartridge forming an aerosol delivery device. The control body includes a control component to control the heating element to activate and vaporize components of the aerosol precursor composition. The control body also includes a gas sensor configured to detect a presence of gas in an environment of the control body, and the gas sensor or control component are further configured to control operation of at least one functional element of the aerosol delivery device in response to the presence of gas so detected.

A system for at least partial closed-loop control of a medical condition is disclosed. The system includes at least one medical fluid pump. The medical fluid pump including a sensor for determining the volume of fluid pumped by the pump. Also, at least one continuous analyte monitor, and a controller. The controller is in communication with the medical fluid pump and the at least one continuous analyte monitor. The controller includes a processor. The processor includes instructions for delivery of medical fluid based at least on data received from the at least one continuous analyte monitor.

Embodiments of a negative pressure wound therapy systems and methods for operating the systems are disclosed. In some embodiments, a system includes a pump assembly, canister, and a wound dressing configured to be positioned over a wound. The pump assembly, canister, and the wound dressing can be fluidically connected to facilitate delivery of negative pressure to a wound. The system can be configured to efficiently deliver negative pressure in continuous and intermittent modes. The system can also be configured to gradually ramp up and down to set pressure values. The system can also be configured to detect and indicate presence of certain conditions, such as low pressure, high pressure, leak, canister full, and the like. Detection and indication of the presence of at least some of these conditions can be enabled and disabled.

The present disclosure provides an aerosol precursor consumable, and an aerosol delivery device that comprises a control unit that defines a receiving chamber, and a removable and replaceable aerosol precursor consumable, at least a portion of the consumable configured to be received into the receiving chamber. The aerosol precursor consumable comprises a housing defining an outer wall, an aerosol precursor composition reservoir located in the housing and configured to contain an aerosol precursor composition, an atomizer located in the housing, and at least one aroma diffuser. The atomizer is configured to vaporize the aerosol precursor composition to generate an aerosol for oral delivery to a user, and the at least one aroma diffuser is configured to diffuse an aroma composition for olfactory delivery to the user.

An electronic smoking device (10) is provided including a power supply portion (12) comprising a power supply (18), an atomizer/liquid reservoir portion (14) comprising a liquid reservoir (34) storing a liquid, and an atomizer (26) adapted to atomize the liquid stored in the liquid reservoir (34) when operated by the power supply (18). The atomizer (26) extends away from the liquid reservoir (34) in a first direction (L). The atomizer (26) comprises first atomizer sections (28a, 28b, 28c, 28d), wherein each of the first atomizer sections defines an opening (50a, 50b, 50c, 50d) that is at least partly encircled by the first atomizer section. The sizes of the openings defined by the first atomizer sections decrease with increasing distance of the first atomizer sections from the liquid reservoir in the first direction.

The systems and methods described herein determine metrics of cardiac or vascular performance, such as cardiac output, and can use the metrics to determine appropriate levels of mechanical circulatory support to be provided to the patient. The systems and methods described determine cardiac performance by determining aortic pressure measurements (or other physiologic measurements) within a single heartbeat or across multiple heartbeats and using such measurements in conjunction with flow estimations or flow measurements made during the single heartbeat or multiple heartbeats to determine the cardiac performance, including determining the cardiac output. By utilizing a mechanical circulatory support system placed within the vasculature, the need to place a separate measurement device within a patient is reduced or eliminated. The system and methods described herein may characterize cardiac performance without altering the operation of the heart pump (e.g., without increasing or decreasing pump speed).

Described herein are an interactive apparatus and methods for sensing and measuring real-time characteristic patterns of a subject's use of a dry powder inhalation system. The inhaler device can be used in a wireless communication mode to communicate with a display to assess the subject's usage of the inhalation system concurrently as the inhalation is performed and thus the subject's inhalation can be evaluated as well as the performance of the inhalation system. The system can also detect the identity of the medicament, its dosage, lot, expiration, etc. and the characteristics profile of a dry powder formulation emitted from the inhalation system in use.