An apparatus and method for aspirating, irrigating and/or cleansing wounds is provided. The apparatus and method include one or more of the following: simultaneous aspiration and irrigation of the wound, supplying of thermal energy to fluid circulated through the wound; supplying physiologically active agents to the wound; a biodegradable scaffold in contact with the wound bed; and application of stress or flow stress to the wound bed.

The present disclosure relates generally to the field of nicotine delivery. The disclosure teaches a nicotine meta-salicylate. More specifically, the disclosure teaches a condensation nicotine aerosol where nicotine meta-salicylate is vaporized. This disclosure relates to aerosol nicotine delivery devices. The delivery devices can be activated by actuation mechanisms to vaporize thin films comprising a nicotine meta-salicylate. More particularly, this disclosure relates to thin films of nicotine salt with meta salicylic acid for the treatment of nicotine craving and for effecting smoking cessation.

An aerosol-generating system is provided, including an aerosol-generating article and an aerosol-generating device. The aerosol-generating article includes a first compartment having a first one of a volatile delivery enhancing compound source and a medicament source; and a second compartment having a second one of the volatile delivery enhancing compound source and the medicament source. The aerosol-generating device includes a cavity configured to receive the first compartment and the second compartment; and an external heater positioned about a perimeter of the cavity. The aerosol-generating device is configured to heat the first compartment and the second compartment so that the first compartment has a lower temperature than the second compartment.

Apparatuses (including devices, kits, and systems) and methods to non-invasively and chemically (rather than thermally) activate thermoreceptors to modulate sleep. For example, described herein are apparatuses including topical compositions that stimulate thermoreceptors on the subject's skin (e.g., forehead, hands, and/or feet) for a period of time to induce a sensation of temperature (heat or cold) without significantly altering the person's actual skin temperature to improve sleep quality, including reducing sleep-onset latency, enhancing depth of sleep, and/or extending the amount of time a subject sleeps. The subject may be suffering from insomnia or some other sleep disorder.

A system includes a nasal cannula having a flexible tube configured to transmit oxygen gas to a user, an optical fiber coupled to the nasal cannula and configured to transmit light having a frequency spectrum range at least including that of light resulting from combustion of the nasal cannula while transmitting the oxygen gas to the user, a detector operatively coupled to the optical fiber and configured to detect the light transmitted through the optical fiber, and a valve. The valve is configured to be actuated to interrupt the transmission of the oxygen gas to the user through the nasal cannula in response to a signal from the detector.

Provided is an aerosol generating system including a holder configured to generate aerosol by heating a cigarette; and a cradle including an inner space into which the holder is inserted. The holder is configured to be tiltable with respect the cradle. The holder is inserted into the inner space of the cradle and then tilted to generate the aerosol.

A skin-patch type large volume drug delivery device (1) comprising a heat exchanger (24) to extract thermal energy from the body/skin surface of the user and to supply the extracted thermal energy to increase the temperature of the medicament. Alternatively or in addition, a Peltier element (35) can be used for the same purpose. The device includes a temperature sensor (31) and a controller (16) for varying the flow rate within the heat exchanger as a function of the drug temperature.

Provided is a multi-users cannabis dispenser comprising: a vessel comprising at least two compartments, each compartment configured to contain at least one cannabis composition comprising at least one active component; at least one dispensing unit associated with said at least one compartment, said dispensing unit configured to controllably release from said compartments a metered dose of said composition contained therein; a control unit comprising a data input unit configured to receive data relating to a specific user, data indicating a metered dose of one or more said cannabis compositions to be administered to said specific user and/or to receive data relating to a specific cannabis composition, data indicating a metered dose of said specific composition to be administered to said specific user and configured to control the dispensing unit to release at least one said metered dose. Further provided are methods of use of the multi-users cannabis dispenser.

A device configured to deliver a medicament to a user by injection, comprising an injection feedback apparatus configured to apply temperature-based feedback to the user regarding the delivery of the medicament.

A drug delivery system includes a substrate, an integrated sensor disposed on the substrate, a drug delivery element disposed on the substrate, and a control unit coupled to the integrated sensor and the drug delivery element. The integrated sensor includes first and second electrodes disposed on a first surface of the substrate. The drug delivery element includes a reservoir disposed on the first surface of the substrate, a thermally active polymer enclosing the reservoir, and a heating coil disposed over the thermally active polymer. The control unit is configured to measure a biological parameter by measuring a voltage difference between the first and second electrodes of the integrated sensor, and to apply a trigger signal to the heating coil of the drug delivery element responsive to the measured biological parameter indicating a designated condition to heat up the thermally active polymer to selectively release a drug from the reservoir.